Electron beam therapy: Microdosimetric calculations for the quantification of fundamental damaging processes

  • Electron beam therpy is used to treat tumor cells by irradiation with high energy electrons (HEE). The irradiation is performed by medical linear accelerators. By interaction of the HEE with the irradiated tissue a broad spectra of secondary electrons and water dissoziation products is generated. These products interact with biomolecules, especially DNA, by various processes. The disentanglement of the resulting direct- and indirect damage to DNA and other cellular components is still under debate. To increase the efficiency of future therapies a better understanding of the microscopic damaging processes is highly important. Especially the various contributions of the secondary species produced, such as low energy electrons (LEE) and radicals is far from understood and quantified. To increase the understanding we present a combination of a microdosimetric simulations and experiments to quantify the damage by means of electron scattering and diffusion simulations within theElectron beam therpy is used to treat tumor cells by irradiation with high energy electrons (HEE). The irradiation is performed by medical linear accelerators. By interaction of the HEE with the irradiated tissue a broad spectra of secondary electrons and water dissoziation products is generated. These products interact with biomolecules, especially DNA, by various processes. The disentanglement of the resulting direct- and indirect damage to DNA and other cellular components is still under debate. To increase the efficiency of future therapies a better understanding of the microscopic damaging processes is highly important. Especially the various contributions of the secondary species produced, such as low energy electrons (LEE) and radicals is far from understood and quantified. To increase the understanding we present a combination of a microdosimetric simulations and experiments to quantify the damage by means of electron scattering and diffusion simulations within the Geant4-DNA framework. In combination with in-liquid irradiation of plasmid DNA it possible to determine microdosimetric quantities for biomolecules in liquid environment. The presented method was applied to the irradiation of plasmid DNA (pUC19) in water. This opens up new possibilities in radiation research to quantify the dosage-damage relationship for microscopic plasmid volumes under well defined physiological condition.zeige mehrzeige weniger

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Metadaten
Autor*innen:Marc Benjamin HahnORCiD
Koautor*innen:Susann Meyer, Maria-Astrid Schroeter, Hans-Jörg Kunte, Tihomir Solomun, Heinz Sturm
Dokumenttyp:Posterpräsentation
Veröffentlichungsform:Präsentation
Sprache:Englisch
Jahr der Erstveröffentlichung:2017
DDC-Klassifikation:Naturwissenschaften und Mathematik / Chemie / Analytische Chemie
Freie Schlagwörter:DNA; Dosimetry; Electron irradiation; Microdosimetry; Monte-Carlo simulation
Veranstaltung:IWBBIO17
Veranstaltungsort:Granada. Spain
Beginndatum der Veranstaltung:25.04.2017
Enddatum der Veranstaltung:29.04.2017
Verfügbarkeit des Dokuments:Datei im Netzwerk der BAM verfügbar ("Closed Access")
Datum der Freischaltung:03.05.2017
Referierte Publikation:Nein
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