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Exploiting termite nest microbiomes for antibiotic drug discovery by using an ultra-high throughput Microfluidics/FACS driven pipeline

  • Bacterial infections are a global threat to human health1. Especially nosocomial infections with multidrug-resistant Gram-negative bacteria challenge public health systems and endanger successful treatment of patients in many modern medicine applications as e.g. organ transplant. In the last three decades classical approaches failed to find novel chemical scaffolds suitable for the development of antibiotics that reach the market and caused the modern antibiotics crisis1. Insect microbiomes produce potent antibiotics with low toxicity to eukaryotic cells to defend their hosts against entomopathogenic microorganisms2. In order to exploit insect microbiomes efficiently and to identify novel antibiotics producing bacteria, we implemented an ultra-high throughput Microfluidics/FACS (fluorescence-associated cell sorting) cultivation and screening pipeline. Here we present the technical aspects of our pipeline including downstream processing of identified producer strains and itsBacterial infections are a global threat to human health1. Especially nosocomial infections with multidrug-resistant Gram-negative bacteria challenge public health systems and endanger successful treatment of patients in many modern medicine applications as e.g. organ transplant. In the last three decades classical approaches failed to find novel chemical scaffolds suitable for the development of antibiotics that reach the market and caused the modern antibiotics crisis1. Insect microbiomes produce potent antibiotics with low toxicity to eukaryotic cells to defend their hosts against entomopathogenic microorganisms2. In order to exploit insect microbiomes efficiently and to identify novel antibiotics producing bacteria, we implemented an ultra-high throughput Microfluidics/FACS (fluorescence-associated cell sorting) cultivation and screening pipeline. Here we present the technical aspects of our pipeline including downstream processing of identified producer strains and its suitability for antibiotics discovery.zeige mehrzeige weniger

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Metadaten
Autor*innen:J. Glaeser, M. Oberpaul
Koautor*innen:M. Ngyuen, T. Stadler, J. Fracowiak, F. Zubell, Rüdiger Plarre, P. Hammann, A. Vilcinskas
Dokumenttyp:Posterpräsentation
Veröffentlichungsform:Präsentation
Sprache:Englisch
Jahr der Erstveröffentlichung:2017
DDC-Klassifikation:Technik, Medizin, angewandte Wissenschaften / Ingenieurwissenschaften
Freie Schlagwörter:Antibiotics; Micobiomes; Termites
Veranstaltung:Tagung DGHM und VAAM Microbiology and Infection 2017
Veranstaltungsort:Würzburg, Germany
Beginndatum der Veranstaltung:05.03.17
Enddatum der Veranstaltung:08.03.17
Verfügbarkeit des Dokuments:Datei im Netzwerk der BAM verfügbar ("Closed Access")
Datum der Freischaltung:24.04.2017
Referierte Publikation:Nein
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