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What is in the fish? Collaborative trial in suspect and non-target screening of organic micropollutants using LC- and GC-HRMS

  • A collaborative trial involving 16 participants from nine European countries was conducted within the NORMAN network in efforts to harmonise suspect and non-target screening of environmental contaminants in whole fish samples of bream (Abramis brama). Participants were provided with freeze-dried, homogenised fish samples from a contaminated and a reference site, extracts (spiked and non-spiked) and reference sample preparation protocols for liquid chromatography (LC) and gas chromatography (GC) coupled to high resolution mass spectrometry (HRMS). Participants extracted fish samples using their in-house sample preparation method and/or the protocol provided. Participants correctly identified 9-69% of spiked compounds using LC-HRMS and 20-60% of spiked compounds using GC-HRMS. From the contaminated site, suspect screening with participants’ own suspect lists led to putative identification of on average ~145 and ~20 unique features per participant using LC-HRMS and GC-HRMS, respectively,A collaborative trial involving 16 participants from nine European countries was conducted within the NORMAN network in efforts to harmonise suspect and non-target screening of environmental contaminants in whole fish samples of bream (Abramis brama). Participants were provided with freeze-dried, homogenised fish samples from a contaminated and a reference site, extracts (spiked and non-spiked) and reference sample preparation protocols for liquid chromatography (LC) and gas chromatography (GC) coupled to high resolution mass spectrometry (HRMS). Participants extracted fish samples using their in-house sample preparation method and/or the protocol provided. Participants correctly identified 9-69% of spiked compounds using LC-HRMS and 20-60% of spiked compounds using GC-HRMS. From the contaminated site, suspect screening with participants’ own suspect lists led to putative identification of on average ~145 and ~20 unique features per participant using LC-HRMS and GC-HRMS, respectively, while non-target screening identified on average ~42 and ~56 unique features per participant using LC-HRMS and GC-HRMS, respectively. Within the same sub-group of sample preparation method, only a few features were identified by at least two participants in suspect screening (16 features using LC-HRMS, 0 features using GC-HRMS) and non-target screening (0 features using LC-HRMS, 2 features using GC-HRMS). The compounds identified had log octanol/water partition coefficient (KOW) values ranging from -9.9 to 16 and mass-to-charge ratio (m/z) of 68 to 761 (LC-HRMS and GC-HRMS). A significant linear trend was found between log KOW and m/z for the GC-HRMS data. Overall, these findings indicate that differences in screening results are mainly due to the data analysis workflows used by different participants. Further work is needed to harmonise the results obtained when applying suspect and non-target screening approaches to environmental biota samples.zeige mehrzeige weniger

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Autor*innen:Wiebke Dürig, Sofia LindbladORCiD, Oksana Golovko, Georgios Gkotsis, Reza AalizadehORCiD, Maria-Christina NikaORCiD, Nikolaos ThomaidisORCiD, Nikiforos A. Alygizakis, Merle Plassmann, Peter Haglund, Qiuguo Fu, Juliane HollenderORCiD, Jade Chaker, Arthur DavidORCiD, Uwe Kunkel, André MacheriusORCiD, Lidia Belova, Giulia PomaORCiD, Hugues Preud'Homme, Catherine Munschy, Yann AminotORCiD, Carsten JaegerORCiD, Jan LisecORCiD, Martin HansenORCiD, Katrin VorkampORCiD, Linyan Zhu, Francesca Cappelli, Claudio RoscioliORCiD, Sara ValsecchiORCiD, Renzo Bagnati, Belén GonzálezORCiD, Ailette Prieto, Olatz Zuloaga, Ruben Gil-Solsona, Pablo Gago-Ferrero, Sara Rodriguez-MozazORCiD, Hélène Budzinski, Marie-Helene Devier, Georg Dierkes, Lise Boulard, Griet Jacobs, Stefan Voorspoels, Heinz RüdelORCiD, Lutz AhrensORCiD
Dokumenttyp:Zeitschriftenartikel
Veröffentlichungsform:Verlagsliteratur
Sprache:Englisch
Titel des übergeordneten Werkes (Englisch):Environment International
Jahr der Erstveröffentlichung:2023
Organisationseinheit der BAM:1 Analytische Chemie; Referenzmaterialien
1 Analytische Chemie; Referenzmaterialien / 1.7 Organische Spuren- und Lebensmittelanalytik
1 Analytische Chemie; Referenzmaterialien / 1.8 Umweltanalytik
Verlag:Elsevier B.V.
Jahrgang/Band:181
Aufsatznummer:108288
Erste Seite:1
Letzte Seite:24
DDC-Klassifikation:Technik, Medizin, angewandte Wissenschaften / Ingenieurwissenschaften / Sanitär- und Kommunaltechnik; Umwelttechnik
Freie Schlagwörter:Biota; Collaborative trial; Expobome; General Environmental Science; Suspect and non-target analysis
Themenfelder/Aktivitätsfelder der BAM:Umwelt
DOI:10.1016/j.envint.2023.108288
Verfügbarkeit des Dokuments:Datei im Netzwerk der BAM verfügbar ("Closed Access")
Datum der Freischaltung:30.10.2023
Referierte Publikation:Ja
Datum der Eintragung als referierte Publikation:13.11.2023
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