Electron irradiation of biomolecules under physiological conditions: Experimental realization and microdosimetric calculations
- In the last years, secondary low-energy electrons (LEE) emerged as important, if not predominant, reductive pathway in ionizing damage of biomolecules. These electrons are created in copious amount as result of inelastic scattering of high energy radiation at water. Until now, all experiments the quantification of the effects of LEEs on the biomolecular damage was either performed in vacuum with LEE sources or with DNA on surfaces in humid atmosphere. We present a new experimental setup to irradiate biomolecules with electrons under physiological conditions. In combination with monte carlo simulations this setup makes it possible to determine microdosimetric quantities for biomolecules in liquid environment under electron irradiation. This opens up new possibilities in radiation research to access the LEE damage under well defined physiological condition, for more complex systems, such as DNA-Protein complexes and even living cells.
Autor*innen: | Marc Benjamin HahnORCiD |
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Weitere Person: | Susan Meyer, Tihomir Solomun, Hans-Jörg KunteORCiD, Heinz SturmORCiD |
Dokumenttyp: | Posterpräsentation |
Veröffentlichungsform: | Präsentation |
Sprache: | Englisch |
Jahr der Erstveröffentlichung: | 2016 |
DDC-Klassifikation: | Technik, Medizin, angewandte Wissenschaften / Ingenieurwissenschaften / Ingenieurwissenschaften und zugeordnete Tätigkeiten |
Technik, Medizin, angewandte Wissenschaften / Ingenieurwissenschaften / Sanitär- und Kommunaltechnik; Umwelttechnik | |
Freie Schlagwörter: | DNA; Dosimetry; Geant4; Low energy electrons; Microdosimetry; Polymers; Radiation damage; Radicals |
Veranstaltung: | 14th International Congress of the International Radiation Protection Association |
Veranstaltungsort: | Cape Town, South Africa |
Beginndatum der Veranstaltung: | 09.05.2016 |
Enddatum der Veranstaltung: | 12.05.2016 |
Verfügbarkeit des Dokuments: | Datei im Netzwerk der BAM verfügbar ("Closed Access") |
Datum der Freischaltung: | 08.06.2016 |
Referierte Publikation: | Nein |