Z. Yu, B. Musnier, Karl David Wegner, M. Henry, B. Chovelon, A. Desroches-Castan, A. Fertin, Ute Resch-Genger, S. Bailly, J.-L. Coll, Y, Usson, V. Josserand, X. Le Gúevel
- We synthesized a generation of water-soluble, atomically precise gold nanoclusters (Au NCs) with anisotropic Surface containing a short dithiol pegylated chain (AuMHA/TDT). The AuMHA/TDT exhibit a high brightness (QY ∼ 6%) in the shortwave infrared (SWIR) spectrum with a detection above 1250 nm.
Furthermore, they show an extended half-life in blood (t1/2ß = 19.54 ± 0.05 h) and a very weak accumulation in organs. We also developed a non-invasive, whole-body vascular imaging system in the SWIR window with high-resolution, benefiting from a series of Monte Carlo image processing. The imaging process enabled to improve contrast by 1 order of magnitude and enhance the spatial Resolution by 59%. After systemic administration of these nanoprobes in mice, we can quantify vessel complexity in depth (>4 mm), allowing to detect very subtle vascular disorders non-invasively in bone morphogenetic protein 9 (Bmp9)-deficient mice. The combination of these anisotropic surface charged Au NCs plus anWe synthesized a generation of water-soluble, atomically precise gold nanoclusters (Au NCs) with anisotropic Surface containing a short dithiol pegylated chain (AuMHA/TDT). The AuMHA/TDT exhibit a high brightness (QY ∼ 6%) in the shortwave infrared (SWIR) spectrum with a detection above 1250 nm.
Furthermore, they show an extended half-life in blood (t1/2ß = 19.54 ± 0.05 h) and a very weak accumulation in organs. We also developed a non-invasive, whole-body vascular imaging system in the SWIR window with high-resolution, benefiting from a series of Monte Carlo image processing. The imaging process enabled to improve contrast by 1 order of magnitude and enhance the spatial Resolution by 59%. After systemic administration of these nanoprobes in mice, we can quantify vessel complexity in depth (>4 mm), allowing to detect very subtle vascular disorders non-invasively in bone morphogenetic protein 9 (Bmp9)-deficient mice. The combination of these anisotropic surface charged Au NCs plus an improved SWIR imaging device allows a precise mapping at high-resolution and an in depth understanding of the organization of the vascular network in live animals.…
MetadatenAutor*innen: | Z. Yu, B. Musnier, Karl David WegnerORCiD, M. Henry, B. Chovelon, A. Desroches-Castan, A. Fertin, Ute Resch-GengerORCiD, S. Bailly, J.-L. Coll, Y, Usson, V. Josserand, X. Le Gúevel |
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Dokumenttyp: | Zeitschriftenartikel |
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Veröffentlichungsform: | Verlagsliteratur |
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Sprache: | Englisch |
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Titel des übergeordneten Werkes (Englisch): | American Chemical Society |
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Jahr der Erstveröffentlichung: | 2020 |
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Organisationseinheit der BAM: | 1 Analytische Chemie; Referenzmaterialien |
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| 1 Analytische Chemie; Referenzmaterialien / 1.2 Biophotonik |
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Verlag: | ACS Publication |
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Jahrgang/Band: | 14 |
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Ausgabe/Heft: | 4 |
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Erste Seite: | 4973 |
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Letzte Seite: | 4981 |
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DDC-Klassifikation: | Naturwissenschaften und Mathematik / Chemie / Analytische Chemie |
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| Technik, Medizin, angewandte Wissenschaften / Ingenieurwissenschaften / Ingenieurwissenschaften und zugeordnete Tätigkeiten |
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Freie Schlagwörter: | Decay kinetics; Fluorescence; Lifetime; Ligand; Mechanism; Metal cluster; NIR; Nanoparticle; Nanosensor; Photophysics; Quantum yield; SWIR; Size; Surface chemistry |
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Themenfelder/Aktivitätsfelder der BAM: | Material |
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| Material / Nano |
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| Umwelt |
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| Umwelt / Sensorik |
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DOI: | 10.1021/acsnano.0c01174 |
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Verfügbarkeit des Dokuments: | Datei im Netzwerk der BAM verfügbar ("Closed Access") |
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Datum der Freischaltung: | 20.04.2020 |
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Referierte Publikation: | Ja |
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Datum der Eintragung als referierte Publikation: | 20.04.2020 |
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