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Surface modifications for photon-upconversion-based energy-transfer nanoprobes

  • An emerging class of inorganic optical reporters are nearinfrared (NIR) excitable lanthanide-based upconversion nanoparticles (UCNPs) with multicolor emission and long luminescence lifetimes in the range of several hundred microseconds. For the design of chemical sensors and optical probes that reveal analyte-specific changes in their spectroscopic properties, these nanomaterials must be combined with sensitive indicator dyes that change their absorption and/or fluorescence properties selectively upon interaction with their target analyte, utilizing either resonance energy transfer (RET) processes or reabsorption-related inner filter effects. The rational development of UCNP-based nanoprobes for chemical sensing and imaging in a biological environment requires reliable methods for the Surface functionalization of UCNPs, the analysis and quantification of Surface groups, a high colloidal stability of UCNPs in aqueous media as well as the chemically stable attachment of the indicatorAn emerging class of inorganic optical reporters are nearinfrared (NIR) excitable lanthanide-based upconversion nanoparticles (UCNPs) with multicolor emission and long luminescence lifetimes in the range of several hundred microseconds. For the design of chemical sensors and optical probes that reveal analyte-specific changes in their spectroscopic properties, these nanomaterials must be combined with sensitive indicator dyes that change their absorption and/or fluorescence properties selectively upon interaction with their target analyte, utilizing either resonance energy transfer (RET) processes or reabsorption-related inner filter effects. The rational development of UCNP-based nanoprobes for chemical sensing and imaging in a biological environment requires reliable methods for the Surface functionalization of UCNPs, the analysis and quantification of Surface groups, a high colloidal stability of UCNPs in aqueous media as well as the chemically stable attachment of the indicator molecules, and suitable instrumentation for the spectroscopic characterization of the energy-transfer systems and the derived nanosensors. These topics are highlighted in the following feature article, and examples of functionalized core−shell nanoprobes for the sensing of different biologically relevant analytes in aqueous environments will be presented. Special emphasis is placed on the intracellular sensing of pH.zeige mehrzeige weniger

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Metadaten
Autor*innen:Ute Resch-GengerORCiD, Elina AndresenORCiD, M. Schäferling
Dokumenttyp:Zeitschriftenartikel
Veröffentlichungsform:Verlagsliteratur
Sprache:Englisch
Titel des übergeordneten Werkes (Englisch):Langmuir
Jahr der Erstveröffentlichung:2019
Organisationseinheit der BAM:1 Analytische Chemie; Referenzmaterialien
1 Analytische Chemie; Referenzmaterialien / 1.2 Biophotonik
Verlag:ACS
Jahrgang/Band:35
Ausgabe/Heft:15
Erste Seite:5093
Letzte Seite:5113
DDC-Klassifikation:Naturwissenschaften und Mathematik / Chemie / Analytische Chemie
Technik, Medizin, angewandte Wissenschaften / Ingenieurwissenschaften / Ingenieurwissenschaften und zugeordnete Tätigkeiten
Freie Schlagwörter:FRET; Lanthanide; Lifetime; Nano; Nanomaterial; Photoluminescence; Photophysics; Quantum yield; Sensor; Surface chemistry; Upconversion nanoparticle
Themenfelder/Aktivitätsfelder der BAM:Chemie und Prozesstechnik
Material
Material / Degradation von Werkstoffen
DOI:10.1021/acs.langmuir.9b00238
ISSN:0743-7463
Verfügbarkeit des Dokuments:Datei im Netzwerk der BAM verfügbar ("Closed Access")
Datum der Freischaltung:15.05.2019
Referierte Publikation:Ja
Datum der Eintragung als referierte Publikation:15.05.2019
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