Simple method for the quantification of PEG ligands and guidelines to the spectroscopic characterization of upconversion nanoparticles
- The surface modification of nanometer- and micrometer-sized particles with polyethylene glycol (PEG) ligands of varying length is a very common strategy to tune their hydrophilicity and biocompatibility, minimize unspecific interactions, improve biofunctionalization efficiencies, and enhance blood circulation times. Nevertheless, simple methods for the quantification of PEG ligands are rare. This is similarly true for the spectroscopic characterization of lanthanide-doped upconverting nanoparticles (UCNPs), novel near infrared (NIR)-excitable nonlinear fluorescence reporters for bioanalysis and theranostics, providing background-free multiple narrow emission bands in the visible and NIR, excellent photostability, and long luminescence lifetimes. We present here a simple method for the determination of the number of PEG ligands on nanomaterials and screening methods for the fast identification of nonradiative deaction pathways in UCNPs.
Autor*innen: | Ute Resch-GengerORCiD |
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Koautor*innen: | Marko Moser, Marco Kraft, Christian WürthORCiD, Thomas Behnke, Jana FalkenhagenORCiD, Martin Kaiser, V. Muhr, T. Hirsch |
Dokumenttyp: | Vortrag |
Veröffentlichungsform: | Präsentation |
Sprache: | Englisch |
Jahr der Erstveröffentlichung: | 2016 |
DDC-Klassifikation: | Naturwissenschaften und Mathematik / Chemie / Analytische Chemie |
Freie Schlagwörter: | Fluorescence; IR; Integrating sphere spectroscopy; Ligand analysis; NIR; Nanomaterials; Optical assay; Optical spectroscopy; Quantum yield; Semiconducor nanocrystals; Surface analysis;; Upconversion nanocrystals |
Veranstaltung: | SPIE Photonics West |
Veranstaltungsort: | San Francisco, CA, USA |
Beginndatum der Veranstaltung: | 15.02.2016 |
Enddatum der Veranstaltung: | 18.02.2016 |
Verfügbarkeit des Dokuments: | Datei im Netzwerk der BAM verfügbar ("Closed Access") |
Datum der Freischaltung: | 10.08.2016 |
Referierte Publikation: | Nein |
Eingeladener Vortrag: | Nein |