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SI-traceable monoelemental solutions on the highest level of accuracy: From the foundation of CCQM to recent advances

  • Shortly after founding the CCQM in 1993, the first key comparison (CCQM-K2) about the determination of Cd and Pb content in river water was hosted by IRMM. It has been clear from the beginning that for the determination of an element mass fraction in a matrix, accurate reference solutions would be the key point for a metrologically sound analysis. Triggered by the not entirely satisfactory results it was decided to investigate the basis of all measurements: the reference solutions. Thus in 1999, CCQM-K8, hosted by EMPA/LNE, started the tedious but indispensable work on elemental solutions standards. Additionally, PTB, BAM and Merck KGaA initiated a project to establish a traceability system for inorganic analysis based on accurate monoelemental solutions. Within this unique approach ten high purity reference materials were fully characterized, and solutions were prepared gravimetrically thereof. These materials (forming the primary standards of elemental analysis) are available forShortly after founding the CCQM in 1993, the first key comparison (CCQM-K2) about the determination of Cd and Pb content in river water was hosted by IRMM. It has been clear from the beginning that for the determination of an element mass fraction in a matrix, accurate reference solutions would be the key point for a metrologically sound analysis. Triggered by the not entirely satisfactory results it was decided to investigate the basis of all measurements: the reference solutions. Thus in 1999, CCQM-K8, hosted by EMPA/LNE, started the tedious but indispensable work on elemental solutions standards. Additionally, PTB, BAM and Merck KGaA initiated a project to establish a traceability system for inorganic analysis based on accurate monoelemental solutions. Within this unique approach ten high purity reference materials were fully characterized, and solutions were prepared gravimetrically thereof. These materials (forming the primary standards of elemental analysis) are available for NMIs/DIs from BAM. CCQM-P46 (Cu, Mg, Rh) demonstrated the actuality of the topic and the challenges to prepare elemental solutions for every element. The accurate preparation and use of monoelemental solutions is consequently reflected in the recurrent conduct of (key) comparisons: CCQM-P149 (purity of zinc), CCQM-K87 (Co, Cr, Pb), and the current CCQM-K143/P181 (Cu solutions), to name only a few in a long series. Is it necessary to put so much effort into the preparation of reference solutions? It clearly is! An example outside the world of academia: Recently, EDQM*, PTB, BAM and JRC have developed monoelemental reference standards traceable to the SI for toxic elements in support of the chapters of the European Pharmacopoeia, related to the analysis of elemental impurities in medicinal products. A new ICP OES method has been established allowing the comparison of two 1 g/kg mercury solutions with an outstandingly small uncertainty of Urel(w(Hg)) = 0.16 %. However, this technical progress would not have been possible without the ongoing effort of the metrological community within 25 years of research in the field of high accuracy monoelemental solutions. * EDQM: European Directorate for the Quality of Medicines and HealthCarezeige mehrzeige weniger

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Metadaten
Autor*innen:A. Roethke
Koautor*innen:V. Görlitz, R. Jährling, Heinrich Kipphardt, Ralf Matschat, Silke Richter, O. Rienitz, D. Schiel
Dokumenttyp:Vortrag
Veröffentlichungsform:Präsentation
Sprache:Englisch
Jahr der Erstveröffentlichung:2019
Organisationseinheit der BAM:1 Analytische Chemie; Referenzmaterialien
1 Analytische Chemie; Referenzmaterialien / 1.6 Anorganische Referenzmaterialien
DDC-Klassifikation:Naturwissenschaften und Mathematik / Chemie / Analytische Chemie
Freie Schlagwörter:CCQM; Monoelemental solutions; SI-traceable
Themenfelder/Aktivitätsfelder der BAM:Chemie und Prozesstechnik
Chemie und Prozesstechnik / Chemische Charakterisierung und Spurenanalytik
Veranstaltung:CCQM Workshop on Advances in Metrology in Chemistry and Biology
Veranstaltungsort:Sevre
Beginndatum der Veranstaltung:10.04.2019
Enddatum der Veranstaltung:10.04.2019
URL:https://youtu.be/iVLk8CFnJTI
Verfügbarkeit des Dokuments:Datei im Netzwerk der BAM verfügbar ("Closed Access")
Datum der Freischaltung:24.04.2019
Referierte Publikation:Nein
Eingeladener Vortrag:Nein
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