Five-, four- and three-dentate Europium chelates for anion sensing and their applicability to enzymatic dephosphorylation reactions
- The design of anion-sensitive probes with sufficient sensitivity and selectivity is a demanding task in analytical sciences and chemical sensor technology. The reversible binding of Anions to lanthanide centers is a possible approach for the development of molecular anion sensors, as reversibility is a prerequisite for continuous sensing and monitoring of enzymatic reactions. Some anion species lead to a strong increase of luminescence intensities and lifetimes by the replacement of luminescence quenching water molecules, though the selectivity of the luminescence response is still a major problem. We synthesized a series of positively charged pyridyl-based multidentate europium complexes (five-, four- and three dentate) including sensitizing chromophores and studied their luminescence intensity and lifetime responses to different polyphosphates, pyrophosphate, phosphate anions, and carboxyanions. The results revealed that the number and symmetry of the binding sites have aThe design of anion-sensitive probes with sufficient sensitivity and selectivity is a demanding task in analytical sciences and chemical sensor technology. The reversible binding of Anions to lanthanide centers is a possible approach for the development of molecular anion sensors, as reversibility is a prerequisite for continuous sensing and monitoring of enzymatic reactions. Some anion species lead to a strong increase of luminescence intensities and lifetimes by the replacement of luminescence quenching water molecules, though the selectivity of the luminescence response is still a major problem. We synthesized a series of positively charged pyridyl-based multidentate europium complexes (five-, four- and three dentate) including sensitizing chromophores and studied their luminescence intensity and lifetime responses to different polyphosphates, pyrophosphate, phosphate anions, and carboxyanions. The results revealed that the number and symmetry of the binding sites have a significant impact on the response. The five-dentate complex was used for the real-time monitoring of the activity of the ATP hydrolyzing enzyme apyrase.…
Autor*innen: | Zainelabdeen H. Mohamed, C. Arenz, T. Soukka |
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Dokumenttyp: | Zeitschriftenartikel |
Veröffentlichungsform: | Verlagsliteratur |
Sprache: | Englisch |
Titel des übergeordneten Werkes (Englisch): | Chemistry Select |
Jahr der Erstveröffentlichung: | 2018 |
Organisationseinheit der BAM: | 1 Analytische Chemie; Referenzmaterialien |
1 Analytische Chemie; Referenzmaterialien / 1.2 Biophotonik | |
Verlag: | Wiley-VCH |
Verlagsort: | Weinheim |
Jahrgang/Band: | 3 |
Ausgabe/Heft: | 44 |
Erste Seite: | 12430 |
Letzte Seite: | 12439 |
DDC-Klassifikation: | Naturwissenschaften und Mathematik / Chemie / Analytische Chemie |
Freie Schlagwörter: | Anions; Apyrase; Europium; Luminescence |
Themenfelder/Aktivitätsfelder der BAM: | Umwelt |
Umwelt / Sensorik | |
DOI: | 10.1002/slct.201803287 |
URL: | https://onlinelibrary.wiley.com/doi/10.1002/slct.201803287 |
ISSN: | 2365-6549 |
Verfügbarkeit des Dokuments: | Datei im Netzwerk der BAM verfügbar ("Closed Access") |
Datum der Freischaltung: | 09.01.2019 |
Referierte Publikation: | Ja |
Datum der Eintragung als referierte Publikation: | 09.01.2019 |