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Investigating metabolic transformation processes of pesticides

  • Within a class of agrochemical residues, pesticides are significant concern due to their various adverse effects on people, animals and the environmental systems. Once they entered to food or to the environment, the parent compound is transformed to metabolites which have different toxicity profiles. Activities like food cooking and waste water treatment (WWT) may lead to produce more toxic metabolites than the parent substances. Online coupling of electrochemistry with liquid chromatography mass spectrometry (EC-HPLC-MS) is one of the most promising and powerful techniques for metabolite studies which exploited widely for pharmaceuticals so far [1]. However, data on the application of EC-HPLC-MS to simulate environmental transformation products, the fate of contaminants and their metabolic pathways are rare. The oxidation of analyte of interest on the EC, separate the metabolites on HPLC and identifying them by MS gives enormous advantages to identify the contaminants transformationWithin a class of agrochemical residues, pesticides are significant concern due to their various adverse effects on people, animals and the environmental systems. Once they entered to food or to the environment, the parent compound is transformed to metabolites which have different toxicity profiles. Activities like food cooking and waste water treatment (WWT) may lead to produce more toxic metabolites than the parent substances. Online coupling of electrochemistry with liquid chromatography mass spectrometry (EC-HPLC-MS) is one of the most promising and powerful techniques for metabolite studies which exploited widely for pharmaceuticals so far [1]. However, data on the application of EC-HPLC-MS to simulate environmental transformation products, the fate of contaminants and their metabolic pathways are rare. The oxidation of analyte of interest on the EC, separate the metabolites on HPLC and identifying them by MS gives enormous advantages to identify the contaminants transformation products [2]. Thus, applying this technique (EC-MS, EC-HPLC-MS, and HPLC-EC-MS) for transformation products of pesticide residues is urgently needed. The main interest of this study will be investigating the electrochemical oxidative degradation products, simulating to in-vitro metabolites and transformation processes of selected pesticides in food and environmental samples. The parent pesticides’, like carbamates and abamectin, oxidation by EC, product metabolites identification and their fates will be discussed using electrochemistry coupled to HPLC-MS techniques.zeige mehrzeige weniger

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Autoren/innen:Tessema Fenta Mekonnen
Koautoren/innen:Matthias Koch, Ulrich Panne
Dokumenttyp:Posterpräsentation
Veröffentlichungsform:Präsentation
Sprache:Deutsch
Titel des übergeordneten Werkes (Deutsch):44. Deutscher Lebensmittelchemikertag
Jahr der Erstveröffentlichung:2015
Organisationseinheit der BAM:P Präsidium
1 Analytische Chemie; Referenzmaterialien
1 Analytische Chemie; Referenzmaterialien / 1.7 Organische Spuren- und Lebensmittelanalytik
P Präsidium / P.0 Präsident und Vizepräsident
DDC-Klassifikation:Technik, Medizin, angewandte Wissenschaften / Ingenieurwissenschaften / Sanitär- und Kommunaltechnik; Umwelttechnik
Freie Schlagwörter:EC-MS; Pesticides; Transformation products
Themenfelder/Aktivitätsfelder der BAM:Umwelt
Umwelt / Umweltschadstoffe
Veranstaltung:44. Deutscher Lebensmittelchemikertag
Veranstaltungsort:Karlsruhe, Germany
Beginndatum der Veranstaltung:14.09.2015
Enddatum der Veranstaltung:16.09.2015
Verfügbarkeit des Dokuments:Datei im Netzwerk der BAM verfügbar ("Closed Access")
Datum der Freischaltung:20.02.2016
Referierte Publikation:Nein