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Pharmaceutical drugs under an ocean acidification scenario: the biochemical and transcriptomic effects on the clam Ruditapes philippinarum

  • Carbamazepine (CBZ) and cetirizine (CTZ) are pharmaceutical drugs detected in the aquatic environment. However, the effects to marine invertebrates derived from the combination of these drugs with decreased pH conditions due to ocean acidification are poorly explored. This study investigated the biochemical parameters related to metabolic capacity and oxidative stress response and the transcription of genes related to the mode of action (MoA) of CBZ (1.0 μg/L) and CTZ (0.6 μg/L) in the clam Ruditapes philippinarum chronically exposed (28 days) to control (7.8) and low (7.5) pH conditions. The biochemical parameters applied were: the activity of electron transport system (indicator of organisms’ metabolic capacity); lipid peroxidation content (indicator of cell damage); total glutathione peroxidase activity (indicator of antioxidant defense). The transcription of genes related with drug neurotransmission and metabolism, cell defense and immunity and biomineralization was studied. NoCarbamazepine (CBZ) and cetirizine (CTZ) are pharmaceutical drugs detected in the aquatic environment. However, the effects to marine invertebrates derived from the combination of these drugs with decreased pH conditions due to ocean acidification are poorly explored. This study investigated the biochemical parameters related to metabolic capacity and oxidative stress response and the transcription of genes related to the mode of action (MoA) of CBZ (1.0 μg/L) and CTZ (0.6 μg/L) in the clam Ruditapes philippinarum chronically exposed (28 days) to control (7.8) and low (7.5) pH conditions. The biochemical parameters applied were: the activity of electron transport system (indicator of organisms’ metabolic capacity); lipid peroxidation content (indicator of cell damage); total glutathione peroxidase activity (indicator of antioxidant defense). The transcription of genes related with drug neurotransmission and metabolism, cell defense and immunity and biomineralization was studied. No metabolic changes and oxidative stress was induced by the exposure to CBZ or CTZ at each pH level, but the transcription of several genes related with the MoA (neurotransmission, immunity and biomineralization) was altered by low pH, drug exposure and the combination of both stressors. In conclusion, it was shown that the interaction of drug exposure and low pH conditions can change bivalves’ sensitivity to drugs or alter drugs toxicity.zeige mehrzeige weniger

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Metadaten
Autoren/innen:Â. Almeida
Koautoren/innen:R. Freitas, V. Calisto, V. I. Esteves, Rudolf J. Schneider, A. M. V. M. Soares, E. Figueira, B. Campos, C. Barata
Dokumenttyp:Posterpräsentation
Veröffentlichungsform:Präsentation
Sprache:Englisch
Jahr der Erstveröffentlichung:2018
Organisationseinheit der BAM:1 Analytische Chemie; Referenzmaterialien
1 Analytische Chemie; Referenzmaterialien / 1.8 Umweltanalytik
DDC-Klassifikation:Naturwissenschaften und Mathematik / Chemie / Analytische Chemie
Technik, Medizin, angewandte Wissenschaften / Ingenieurwissenschaften / Sanitär- und Kommunaltechnik; Umwelttechnik
Freie Schlagwörter:Biomarkers; Bivalves; Climate Changes; Pharmaceutical Drugs; Transcriptomic
Themenfelder/Aktivitätsfelder der BAM:Umwelt
Umwelt / Umweltschadstoffe
Analytical Sciences
Analytical Sciences / Spurenanalytik und chemische Zusammensetzung
Veranstaltung:31st Congress of the New European Society for Comparative Physiology and Biochemistry ESCPB
Veranstaltungsort:Porto, Portugal
Beginndatum der Veranstaltung:09.09.2018
Enddatum der Veranstaltung:12.09.2018
Verfügbarkeit des Dokuments:Datei im Netzwerk der BAM verfügbar ("Closed Access")
Datum der Freischaltung:17.09.2018
Referierte Publikation:Nein