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Radioactive gold nanoparticles for cancer treatment: Size and cluster dependent damage studied by Geant4 Monte-Carlo simulations

  • Dose enhancement by gold nanoparticles (AuNP) was shown to increase the biological effectiveness of radiation damage in biomolecules and tissue. Most of the current studies focus on external beam therapy on combination with AuNP. Here we present a Monte-Carlo study (Geant4) to characterise radioactive AuNP. Radioactive ¹⁹⁸Au emits beta and gamma rays and is considered for applications with solid tumours. To effectively apply ¹⁹⁸AuNP their energy deposit characteristics have to be determined in terms of intrinsic and extrinsic properties e.g. AuNP diameter, AuNP density, and their clustering behaviour. After each decay process, the energy deposit, inelastic scattering events, kinetic energy spectrum of secondary particles within the AuNP themselves and in a spherical target volume of water up to 1 μm radius were determined. Simulations were performed for AuNP radii ranging from 2.5 nm to 20 nm radius, different cluster sizes and densities. The results show an increase of the energyDose enhancement by gold nanoparticles (AuNP) was shown to increase the biological effectiveness of radiation damage in biomolecules and tissue. Most of the current studies focus on external beam therapy on combination with AuNP. Here we present a Monte-Carlo study (Geant4) to characterise radioactive AuNP. Radioactive ¹⁹⁸Au emits beta and gamma rays and is considered for applications with solid tumours. To effectively apply ¹⁹⁸AuNP their energy deposit characteristics have to be determined in terms of intrinsic and extrinsic properties e.g. AuNP diameter, AuNP density, and their clustering behaviour. After each decay process, the energy deposit, inelastic scattering events, kinetic energy spectrum of secondary particles within the AuNP themselves and in a spherical target volume of water up to 1 μm radius were determined. Simulations were performed for AuNP radii ranging from 2.5 nm to 20 nm radius, different cluster sizes and densities. The results show an increase of the energy deposit in the vicinity of the AuNP up to 150 nm. This effect nearly vanishes for distances up to one micron. For the case of AuNP clusters and the same activity, the enhancement of the energy deposit increases with the relative gold mass percentage and therefore can be adjusted by changing AuNP radius or clustering behaviour.zeige mehrzeige weniger

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Metadaten
Autoren/innen:Marc Benjamin Hahn, Julian Mateo Zutta Villate
Dokumenttyp:Zeitschriftenartikel
Veröffentlichungsform:Verlagsliteratur
Sprache:Englisch
Titel des übergeordneten Werkes (Englisch):Topical Issue: Dynamics of Systems on the Nanoscale (2018)
Jahr der Erstveröffentlichung:2019
Organisationseinheit der BAM:6 Materialschutz und Oberflächentechnik
6 Materialschutz und Oberflächentechnik / 6.6 Nano-Tribologie und Nanostrukturierung von Oberflächen
Herausgeber (Institution):Società Italiana di Fisica
Verlag:Springer
Verlagsort:Berlin Heidelberg
Jahrgang/Band:73
Ausgabe/Heft:5
Erste Seite:95, 1
Letzte Seite:7
DDC-Klassifikation:Technik, Medizin, angewandte Wissenschaften / Ingenieurwissenschaften / Ingenieurwissenschaften und zugeordnete Tätigkeiten
Freie Schlagwörter:AuNP; Beta decay; Brachytherapy; Cancer treatment; DNA; DNA damage; Dosimetry; Energy deposit; Geant4; Geant4-DNA; Gold Nanoparticles; LEE; MCS; Microdosimetry; Monte-Carlo simulation; NP; OH radicals; Radiation damage; Radiationtherapy; Radioactive decay; Simulation; beta particle; clustered nanoparticles; gamma ray; low energy electrons; particle scattering; radiolysis
Themenfelder/Aktivitätsfelder der BAM:Material
Material / Nanoskalige Materialien und deren Eigenschaften
DOI:https://doi.org/10.1140/epjd/e2019-90707-x
URL:http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=CCC&DestLinkType=FullRecord&KeyUT=CCC:000467692900010
ISSN:1434-6060
ISSN:1434-6079
Verfügbarkeit des Volltexts:Volltext-PDF im Netzwerk der BAM verfügbar ("Closed Access")
Datum der Freischaltung:16.05.2019
Referierte Publikation:Ja
Datum der Eintragung als referierte Publikation:03.06.2019