Zitieren Sie bitte immer diesen URN: urn:nbn:de:kobv:b43-573240
Accessing radiation damage to biomolecules on the nanoscale by particle-scattering simulations
- Radiation damage to DNA plays a central role in radiation therapy to cure cancer. The physico-chemical and biological processes involved encompass huge time and spatial scales. To obtain a comprehensive understanding on the nano and the macro scale is a very challenging tasks for experimental techniques alone. Therefore particle-scattering simulations are often applied to complement measurements and aide their interpretation, to help in the planning of experiments, to predict their outcome and to test damage models. In the last years, powerful multipurpose particle-scattering framework based on the Monte-Carlo simulation (MCS) method, such as Geant4 and Geant4-DNA, were extended by user friendly interfaces such as TOPAS and TOPAS-nBio. This shifts their applicability from the realm of dedicated specialists to a broader range of scientists. In the present review we aim to give an overview over MCS based approaches to understand radiation interaction on a broad scale, ranging fromRadiation damage to DNA plays a central role in radiation therapy to cure cancer. The physico-chemical and biological processes involved encompass huge time and spatial scales. To obtain a comprehensive understanding on the nano and the macro scale is a very challenging tasks for experimental techniques alone. Therefore particle-scattering simulations are often applied to complement measurements and aide their interpretation, to help in the planning of experiments, to predict their outcome and to test damage models. In the last years, powerful multipurpose particle-scattering framework based on the Monte-Carlo simulation (MCS) method, such as Geant4 and Geant4-DNA, were extended by user friendly interfaces such as TOPAS and TOPAS-nBio. This shifts their applicability from the realm of dedicated specialists to a broader range of scientists. In the present review we aim to give an overview over MCS based approaches to understand radiation interaction on a broad scale, ranging from cancerous tissue, cells and their organelles including the nucleus, mitochondria and membranes, over radiosensitizer such as metallic nanoparticles, and water with additional radical scavenger, down to isolated biomolecules in the form of DNA, RNA, proteins and DNA-protein complexes. Hereby the degradation of biomolecules by direct damage from inelastic scattering processes during the physical stage, and the indirect damage caused by radicals during the chemical stage as well as some parts of the early biological response is covered. Due to their high abundance the action of hydroxyl radicals (•OH) and secondary low energy electrons (LEE) as well as prehydrated electrons are covered in additional detail. Applications in the prediction of DNA damage, DNA repair processes, cell survival and apoptosis, influence of radiosensitizer on the dose distribution within cells and their organelles, the study of linear energy transfer (LET), the relative biological effectiveness (RBE), ion beam cancer therapy, microbeam radiation therapy (MRT), the FLASH effect, and the radiation induced bystander effect are reviewed.…
Autor*innen: | Marc Benjamin HahnORCiD |
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Dokumenttyp: | Zeitschriftenartikel |
Veröffentlichungsform: | Verlagsliteratur |
Sprache: | Englisch |
Titel des übergeordneten Werkes (Englisch): | Journal of Physics Communications |
Jahr der Erstveröffentlichung: | 2023 |
Organisationseinheit der BAM: | 6 Materialchemie |
6 Materialchemie / 6.6 Physik und chemische Analytik der Polymere | |
Veröffentlichende Institution: | Bundesanstalt für Materialforschung und -prüfung (BAM) |
Verlag: | Institute of Physics (IOP) Publishing |
Verlagsort: | London |
Jahrgang/Band: | 7 |
Ausgabe/Heft: | 4 |
Erste Seite: | 042001 |
DDC-Klassifikation: | Naturwissenschaften und Mathematik / Chemie / Analytische Chemie |
Technik, Medizin, angewandte Wissenschaften / Ingenieurwissenschaften / Ingenieurwissenschaften und zugeordnete Tätigkeiten | |
Technik, Medizin, angewandte Wissenschaften / Ingenieurwissenschaften / Sanitär- und Kommunaltechnik; Umwelttechnik | |
Freie Schlagwörter: | Au; AuNP; Base damage; Base loss; Beta decay; Bio-SAXS; Brachytherapy; Bragg peak; Bystander effect; Cancer treatment; Carbon ions; Cells; Clustered nanoparticles; Cosolute; DMSO; DNA; DNA damage; DNA radiation damage; DSB; Direct damage; Dissociative electron attachment (DEA); Dissociative electron transfer (DET); Dosimetry; Double-strand break (DSB); ESCA; Ectoin; Ectoine; Electrons; Energy deposit; FLASH effect; G5P; GVP; Geant4; Geant4-DNA; Gene five protein; Gold Nanoparticles; Hydrated DNA; Hydrated electron; Hydration shell; Hydroxyectoine; Hydroxyl radical; Indirect damage; Ion beam therapy; Ionisation; Ionization; Ionizing radiation damage; LET; Livermore model; Low energy electrons; MCNP; MCS; MRT; Microdosimetry; Monte-Carlo simulation; Monte-Carlo simulations; NAP-XPS; NP; Nanodosimetry; Near ambient pressure xray photo electron spectroscopy; Net-ionization reaction; OH; OH radical; OH radical scavenger; Osmolyte; Particle scattering; Particle scattering simulations; Penelope model; Photons; Prehydrated electron; Presolvated electron; Protein; Protein unfolding; Proteins; Quasi-direct damage; RBE; RNA; ROS; Radiation; Radiation damage; Radiation therapy; Radiationtherapy; Radical; Radical Scavenge; Radical scavenger; Radioactive decay; Radiolysis; Radiotherapy; Reactive oxygen species; SAXS; SSB; Simulation; Single-strand break (SSB); Single-stranded DNA-binding proteins; TOPAS; TOPAS-nbio; X-ray scattering; XPS; Xray; Xray photo electron spectrocopy; abasic side; base loss; dsDNA; ssDNA |
Themenfelder/Aktivitätsfelder der BAM: | Chemie und Prozesstechnik |
Material | |
Material / Degradation von Werkstoffen | |
Material / Nano | |
Umwelt | |
Umwelt / Umwelt-Material-Interaktionen | |
DOI: | 10.1088/2399-6528/accb3f |
URN: | urn:nbn:de:kobv:b43-573240 |
ISSN: | 2399-6528 |
Verfügbarkeit des Dokuments: | Datei für die Öffentlichkeit verfügbar ("Open Access") |
Lizenz (Deutsch): | Creative Commons - CC BY - Namensnennung 4.0 International |
Datum der Freischaltung: | 19.04.2023 |
Referierte Publikation: | Ja |
Datum der Eintragung als referierte Publikation: | 31.05.2023 |
Schriftenreihen ohne Nummerierung: | Wissenschaftliche Artikel der BAM |