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Probiotics and probiotic-based vaccines: A novel approach for improving vaccine efficacy
- Vaccination is defined as the stimulation and development of the adaptive immune system by administering specific antigens. Vaccines' efficacy, in inducing immunity, varies in different societies due to economic, social, and biological conditions. One of the influential biological factors is gut microbiota. Cross-talks between gut bacteria and the host immune system are initiated at birth during microbial colonization and directly control the immune responses and protection against pathogen colonization. Imbalances in the gut microbiota composition, termed dysbiosis, can trigger several immune disorders through the activity of the adaptive immune system and impair the adequate response to the vaccination. The bacteria used in probiotics are often members of the gut microbiota, which have health benefits for the host. Probiotics are generally consumed as a component of fermented foods, affect both innate and acquired immune systems, and decrease infections. This review aimed to discussVaccination is defined as the stimulation and development of the adaptive immune system by administering specific antigens. Vaccines' efficacy, in inducing immunity, varies in different societies due to economic, social, and biological conditions. One of the influential biological factors is gut microbiota. Cross-talks between gut bacteria and the host immune system are initiated at birth during microbial colonization and directly control the immune responses and protection against pathogen colonization. Imbalances in the gut microbiota composition, termed dysbiosis, can trigger several immune disorders through the activity of the adaptive immune system and impair the adequate response to the vaccination. The bacteria used in probiotics are often members of the gut microbiota, which have health benefits for the host. Probiotics are generally consumed as a component of fermented foods, affect both innate and acquired immune systems, and decrease infections. This review aimed to discuss the gut microbiota's role in regulating immune responses to vaccination and how probiotics can help induce immune responses against pathogens. Finally, probiotic-based oral vaccines and their efficacy have been discussed.…
Autor*innen: | N. Kazemifard, Abolfazl Dehkohneh, S. Baradaran Ghavami |
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Dokumenttyp: | Zeitschriftenartikel |
Veröffentlichungsform: | Verlagsliteratur |
Sprache: | Englisch |
Titel des übergeordneten Werkes (Englisch): | Frontiers in medicine |
Jahr der Erstveröffentlichung: | 2022 |
Organisationseinheit der BAM: | 4 Material und Umwelt |
4 Material und Umwelt / 4.0 Abteilungsleitung und andere | |
Veröffentlichende Institution: | Bundesanstalt für Materialforschung und -prüfung (BAM) |
Verlag: | Frontiers Media |
Verlagsort: | Lausanne |
Jahrgang/Band: | 9 |
Aufsatznummer: | 940454 |
Erste Seite: | 1 |
Letzte Seite: | 15 |
DDC-Klassifikation: | Technik, Medizin, angewandte Wissenschaften / Ingenieurwissenschaften / Sanitär- und Kommunaltechnik; Umwelttechnik |
Freie Schlagwörter: | Gut microbiota; Probiotic-based vaccines; Probiotics |
Themenfelder/Aktivitätsfelder der BAM: | Umwelt |
DOI: | 10.3389/fmed.2022.940454 |
URN: | urn:nbn:de:kobv:b43-561767 |
ISSN: | 2296-858X |
Verfügbarkeit des Dokuments: | Datei für die Öffentlichkeit verfügbar ("Open Access") |
Lizenz (Deutsch): | Creative Commons - CC BY - Namensnennung 4.0 International |
Datum der Freischaltung: | 09.11.2022 |
Referierte Publikation: | Ja |
Datum der Eintragung als referierte Publikation: | 09.11.2022 |
Schriftenreihen ohne Nummerierung: | Wissenschaftliche Artikel der BAM |