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Microdosimetric measurements for electron irradiation of DNA under physiological conditions: Low energy electrons vs. radicals

  • Radiation damage to DNA is one of the main causes for cancer and likewise a major tool in its treatment. One of the dogma of the classical radiochemistry and physics involves the opinion that radicals such as OH° produced by ionizing radiation are the most lethal agents. This scenario is increasingly disputed as secondary low-energy electrons are emerging [1] as important, if not predominant, reductive pathway in ionizing damage of biomolecules. These electrons are generated in copious amount in aqueous environment as secondary scattering products. But until now all research concerning the quantification of the effects of low energy electrons on the biomolecular damage was either performed in vacuum with low energy electron sources or with DNA plasmids on metallic surfaces in humid environment. In this work we present detailed experimental and simulation microdosimetry data on electron damage to plasmid DNA in liquid environment: Well-defined electron energy and dosage irradiation wasRadiation damage to DNA is one of the main causes for cancer and likewise a major tool in its treatment. One of the dogma of the classical radiochemistry and physics involves the opinion that radicals such as OH° produced by ionizing radiation are the most lethal agents. This scenario is increasingly disputed as secondary low-energy electrons are emerging [1] as important, if not predominant, reductive pathway in ionizing damage of biomolecules. These electrons are generated in copious amount in aqueous environment as secondary scattering products. But until now all research concerning the quantification of the effects of low energy electrons on the biomolecular damage was either performed in vacuum with low energy electron sources or with DNA plasmids on metallic surfaces in humid environment. In this work we present detailed experimental and simulation microdosimetry data on electron damage to plasmid DNA in liquid environment: Well-defined electron energy and dosage irradiation was achieve by using an EM and the irradiation through a nanomembrane. The results are analyzed in terms of single- and double-strand break probabilities in the dependence of dose, energy, number of primary and secondary electrons. The results are important not only from the basic scientific point of view but also for the development of effective radiosensitizers, either as protecting or enhancing (radiotherapy) cofactors.zeige mehrzeige weniger

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Metadaten
Autor*innen:Marc Benjamin HahnORCiD
Koautor*innen:Marc Benjamin Hahn, Susann Meyer, Tihomir Solomun, Hans-Jörg Kunte, Heinz Sturm
Dokumenttyp:Vortrag
Veröffentlichungsform:Präsentation
Sprache:Englisch
Jahr der Erstveröffentlichung:2016
DDC-Klassifikation:Technik, Medizin, angewandte Wissenschaften / Ingenieurwissenschaften / Sanitär- und Kommunaltechnik; Umwelttechnik
Freie Schlagwörter:DNA; dosimetry; geant4; low energy electrons; radiation Damage; radicals
Veranstaltung:14th International Congress of the International Radiation Protection Association
Veranstaltungsort:Cape Town, South Africa
Beginndatum der Veranstaltung:09.05.2016
Enddatum der Veranstaltung:12.05.2016
Verfügbarkeit des Dokuments:Datei im Netzwerk der BAM verfügbar ("Closed Access")
Datum der Freischaltung:08.06.2016
Referierte Publikation:Nein
Eingeladener Vortrag:Nein
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