Flow chemistry using benchtop NMR instruments - Current approaches, chances and limitations
- Intensified continuous processes are in focus of current research. Compared to traditional batch processes, intensified continuous production allows the synthesis of new and difficult producible compounds with better product uniformity and reduced consumption of raw materials and energy. Flexible (modular) chemical plants can produce various products using the same equipment with short down-times between campaigns, and quick introduction of new products to the market. Consequently, the demand for powerful Process Analytical Technologies, which can monitor key variables like component concentrations in real-time, is increasing. Low-Field NMR spectroscopy presents itself as such an upcoming smart sensor1,2 (as addressed, e.g., in the CONSENS project3,4). Continuous measurement approaches can usually be differed in On- or In-line which both have advantages and drawbacks. On the one hand On-line measurements are easy to integrate even in existing setups through bypass systems, on theIntensified continuous processes are in focus of current research. Compared to traditional batch processes, intensified continuous production allows the synthesis of new and difficult producible compounds with better product uniformity and reduced consumption of raw materials and energy. Flexible (modular) chemical plants can produce various products using the same equipment with short down-times between campaigns, and quick introduction of new products to the market. Consequently, the demand for powerful Process Analytical Technologies, which can monitor key variables like component concentrations in real-time, is increasing. Low-Field NMR spectroscopy presents itself as such an upcoming smart sensor1,2 (as addressed, e.g., in the CONSENS project3,4). Continuous measurement approaches can usually be differed in On- or In-line which both have advantages and drawbacks. On the one hand On-line measurements are easy to integrate even in existing setups through bypass systems, on the other hand issues like the representativity of the sampling must be considered. In the case of Inline analysis, where the whole fluid stream is analyzed, this issue can be avoided. Nevertheless, homogeneity of the mixture must be assured using NMR spectroscopy. This talk shall give a brief summary of current Online and Inline Low-Field NMR approaches. Furthermore, current research results using a tailor-made flow cell for inline analysis are shown pointing out the working range as well as limitations of these method in combination with NMR spectroscopy.…
Autor*innen: | Martin Bornemann-PfeifferORCiD |
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Koautor*innen: | Simon KernORCiD, N. Jurtz, M. Kraume, Michael MaiwaldORCiD |
Dokumenttyp: | Vortrag |
Veröffentlichungsform: | Präsentation |
Sprache: | Deutsch |
Jahr der Erstveröffentlichung: | 2019 |
Organisationseinheit der BAM: | 1 Analytische Chemie; Referenzmaterialien |
1 Analytische Chemie; Referenzmaterialien / 1.4 Prozessanalytik | |
DDC-Klassifikation: | Naturwissenschaften und Mathematik / Chemie / Analytische Chemie |
Freie Schlagwörter: | Benchtop NMR; Flow Chemistry; Inline; NMR; PAT |
Themenfelder/Aktivitätsfelder der BAM: | Umwelt |
Umwelt / Sensorik | |
Veranstaltung: | 13. Interdisziplinäres Doktorandenseminar Berlin |
Veranstaltungsort: | Berlin, Germany |
Beginndatum der Veranstaltung: | 18.03.2019 |
Enddatum der Veranstaltung: | 20.03.2019 |
Bemerkung: | Geburtsname von Bornemann-Pfeiffer, Martin: Bornemann, M. - Birth name of Bornemann-Pfeiffer, Martin: Bornemann, M. |
Verfügbarkeit des Dokuments: | Datei im Netzwerk der BAM verfügbar ("Closed Access") |
Datum der Freischaltung: | 19.03.2019 |
Referierte Publikation: | Nein |
Eingeladener Vortrag: | Nein |