BP150: Combined cell and nanoparticle models for TOPAS to study radiation dose enhancement by Monte-Carlo based particle scattering Simulations
- Dose enhancement by gold nanoparticles (AuNP) increases the biological effectiveness of radiation damage in biomolecules and tissue. To apply them effectively during cancer therapy their influence on the locally delivered dose has to be determined. Hereby, the AuNP locations strongly influence the energy deposit in the nucleus, mitochondria, membrane and the cytosol of the targeted cells. In this work, two newly developed continuous and discrete-geometric models for simulations of AuNP in cells are presented. We apply the presented models in Monte-Carlo particle scattering simulations to characterize the energy deposit in cell organelles by radioactive 198AuNP. They emit beta and gamma rays and are therefore considered for applications with solid tumors. Differences in local dose enhancement between randomly distributed and nucleus targeted nanoparticles are compared. Hereby nucleus targeted nanoparticels showed a strong local dose enhancement in the radio sensitive nucleus.
Autor*innen: | Marc Benjamin HahnORCiD |
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Weitere Person: | J. M. Zutta Villate |
Dokumenttyp: | Posterpräsentation |
Veröffentlichungsform: | Präsentation |
Sprache: | Englisch |
Jahr der Erstveröffentlichung: | 2023 |
Organisationseinheit der BAM: | 6 Materialchemie |
6 Materialchemie / 6.6 Physik und chemische Analytik der Polymere | |
DDC-Klassifikation: | Technik, Medizin, angewandte Wissenschaften / Ingenieurwissenschaften / Ingenieurwissenschaften und zugeordnete Tätigkeiten |
Freie Schlagwörter: | AuNP; Beta decay; Beta particle; Brachytherapy; Cancer treatment; Clustered nanoparticles; DNA; DNA damage; Dosimetry; Energy deposit; Geant4; Geant4-DNA; Gold Nanoparticles; LEE; Livermore model; Low energy electrons; MCS; Microdosimetry; Monte-Carlo simulation; NP; OH radical; Particle scattering; Penelope model; Protein; Proteins; Radiation damage; Radiation therapy; Radiationtherapy; Radioactive decay; Radiolysis; Radiotherapy; Simulation; TOPAS; TOPAS-nbio |
Themenfelder/Aktivitätsfelder der BAM: | Material |
Material / Nano | |
Veranstaltung: | DPG Frühjahrstagung |
Veranstaltungsort: | Dresden, Germany |
Beginndatum der Veranstaltung: | 26.03.2023 |
Enddatum der Veranstaltung: | 31.03.2023 |
Verfügbarkeit des Dokuments: | Datei im Netzwerk der BAM verfügbar ("Closed Access") |
Datum der Freischaltung: | 03.04.2023 |
Referierte Publikation: | Nein |