Synthesis and First Crystal Structure of Rhenium Complexes derived from omega-Functionalized Fatty Acids as Model Compounds of Technetium Tracers for Myocardial Metabolism Imaging
- In an attempt to develop new technetium-based radiopharmaceuticals for the noninvasive diagnosis of myocardial metabolism, we have synthesized three examples of novel metal-containing fatty acid derivatives according to the 3+1 mixed-ligand and the Schiff base/tricarbonyl design. The chelates contain the metal core in the oxidation states +5 and +1, respectively, and are attached to the end-position of a fatty acid chain. The complex formation was accomplished by ligand-exchange reactions with three different rhenium precursors, whereas the inactive rhenium metal was utilized as a surrogate of the technetium radionuclide. The molecular structures of the fatty acid complexes 7, 10 and 14 were determined by single-crystal X-ray diffraction analyses and impressively show a general problem in technetium tracer research, namely the significant structural alterations of bioactive molecules by coordination even to small metal chelates.
Autor*innen: | C. M. Jung, Werner Kraus, Peter Leibnitz, H.-J. Pietzsch, J. Kropp, H. Spies |
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Dokumenttyp: | Zeitschriftenartikel |
Veröffentlichungsform: | Verlagsliteratur |
Sprache: | Englisch |
Titel des übergeordneten Werkes (Englisch): | European journal of inorganic chemistry |
Jahr der Erstveröffentlichung: | 2002 |
Verlag: | Wiley-VCH Verl. |
Verlagsort: | Weinheim |
Jahrgang/Band: | 2002 |
Ausgabe/Heft: | 5 |
Erste Seite: | 1219 |
Letzte Seite: | 1225 |
Freie Schlagwörter: | Drug research; Fatty acids; Radiopharmaceuticals; Rhenium; Technetium |
DOI: | 10.1002/1099-0682(200205)2002:5<1219::AID-EJIC1219>3.0.CO;2-N |
ISSN: | 1434-1948 |
ISSN: | 1099-0682 |
Verfügbarkeit des Dokuments: | Physisches Exemplar in der Bibliothek der BAM vorhanden ("Hardcopy Access") |
Bibliotheksstandort: | Sonderstandort: Publica-Schrank |
Datum der Freischaltung: | 19.02.2016 |
Referierte Publikation: | Ja |
Datum der Eintragung als referierte Publikation: | 03.03.2003 |