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Electrochemistry coupled to mass spectrometry (EC/MS) – A valuable tool to simulate metabolic processes of mycotoxins?

  • Mycotoxins are secondary metabolites produced by fungi contaminating food and feed worldwide. Intake of these foodborne toxins can cause several diseases in humans and animals highlighting the need to understand metabolic pathways of mycotoxins. Methods of choice have been in vitro and in vivo approaches, so far. Beside hundreds of documented mycotoxins numerous new ones need to be elucidated and enhance the demand for fast and reliable methods. Here, we present electrochemistry coupled to mass spectrometry (EC/MS set up Fig. 1) as novel and promising tool in mycotoxin research. Electrochemical oxidation of mycotoxins like zearalenone, citrinin or dihydroergocristine lead to several oxidation products known from phase I biotransformation as well as new interesting reaction products analyzed by EC/MS, LC MS/MS and ESI-HRMS. To ensure a comparative overview results obtained from electrochemical oxidation experiments were compared to Fenton reaction, UV irradiation and microsomalMycotoxins are secondary metabolites produced by fungi contaminating food and feed worldwide. Intake of these foodborne toxins can cause several diseases in humans and animals highlighting the need to understand metabolic pathways of mycotoxins. Methods of choice have been in vitro and in vivo approaches, so far. Beside hundreds of documented mycotoxins numerous new ones need to be elucidated and enhance the demand for fast and reliable methods. Here, we present electrochemistry coupled to mass spectrometry (EC/MS set up Fig. 1) as novel and promising tool in mycotoxin research. Electrochemical oxidation of mycotoxins like zearalenone, citrinin or dihydroergocristine lead to several oxidation products known from phase I biotransformation as well as new interesting reaction products analyzed by EC/MS, LC MS/MS and ESI-HRMS. To ensure a comparative overview results obtained from electrochemical oxidation experiments were compared to Fenton reaction, UV irradiation and microsomal experiments. The presentation will point out the benefits and drawbacks of EC/MS in mycotoxin research on the basis of selected food relevant mycotoxins.zeige mehrzeige weniger

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Metadaten
Autor*innen:Julia Keller
Koautor*innen:Dominique Lörchner, Matthias Koch
Dokumenttyp:Vortrag
Veröffentlichungsform:Präsentation
Sprache:Englisch
Jahr der Erstveröffentlichung:2017
DDC-Klassifikation:Naturwissenschaften und Mathematik / Chemie / Analytische Chemie
Freie Schlagwörter:Electrochemistry; Metabolism; Mycotoxin
Veranstaltung:ANAKON
Veranstaltungsort:Tübingen, Deutschland
Beginndatum der Veranstaltung:03.04.2017
Enddatum der Veranstaltung:06.04.2017
Verfügbarkeit des Dokuments:Datei im Netzwerk der BAM verfügbar ("Closed Access")
Datum der Freischaltung:11.04.2017
Referierte Publikation:Nein
Eingeladener Vortrag:Nein
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