Fluorophore-labeled siloxane-based nanoparticles for biomedical applications
- We present the synthesis and characterization of multifunctional fluorophore-labeled poly(organosiloxane) nanoparticles with core-shell architecture, where the fluorescent dye is incorporated into the core. Grafting of heterobifunctional poly(ethylene oxide) (PEO) onto the particle surface leads to water-soluble biocompatible nanoparticles. Two different strategies have been used for the synthesis: The encapsulation of dye-labeled monomers during the polycondensation with additional PEO coating and subsequent dye labeling by covalent attachment of the fluorescent dye rhodamine B to the (chloromethylphenyl)siloxane groups in the core after polymerization and grafting of PEO onto the surface. Comparison of the fluorescence quantum yields of the nanoparticles before and after PEO coating show a decrease in quantum yield after PEO coating.
Autor*innen: | Olga Koshkina, C. Bantz, Christian WürthORCiD, Thomas Lang, Ute Resch-GengerORCiD, Michael Maskos |
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Dokumenttyp: | Zeitschriftenartikel |
Veröffentlichungsform: | Verlagsliteratur |
Sprache: | Englisch |
Titel des übergeordneten Werkes (Englisch): | Macromolecular symposia |
Jahr der Erstveröffentlichung: | 2011 |
Verlag: | Wiley-VCH Verl. |
Verlagsort: | Weinheim |
Jahrgang/Band: | 309/310 |
Ausgabe/Heft: | 1 |
Erste Seite: | 141 |
Letzte Seite: | 146 |
Freie Schlagwörter: | Biocompatibility; Core-shell; Fluorescence; Fluorescence quantum yield; Nanoparticles; PEO |
DOI: | 10.1002/masy.201100041 |
ISSN: | 1022-1360 |
ISSN: | 0258-0322 |
ISSN: | 1521-3900 |
Verfügbarkeit des Dokuments: | Datei im Netzwerk der BAM verfügbar ("Closed Access") |
Datum der Freischaltung: | 19.02.2016 |
Referierte Publikation: | Nein |