In Vivo Tests of a Highly Porous Rapidly Resorbable Dicalcium Potassium Sodium Phosphate Glass-Ceramics
- Glass-ceramics containing Ca2KNa(PO4)2 as the main crystalline phase have a solubility which is 8 times higher than that of alpha-tricalcium phosphate ceramics. When using these compositions in drug delivery systems, especially in bone, it is necessary to create a material with a high open porosity. A Ca2KNa(PO4)2-based glass-ceramic was prepared from a borosilicate glass melt. The processed material includes minor amounts of boron which are low enough for medical application. Tissue response was studied using an animal model. Particles were implanted in rabbit femurs. Bone and soft tissue development occurred at the particle interfaces. In general, most particles were enclosed in the network of trabecular bone. The advantages of using a biomaterial with high porosity (pore size of 1-3 micron), together with rapid biodegradation, bioactivity and biocompatibility, despite traces of boron, were shown. 4 refs.
Autor*innen: | U. Gross, C. Müller-Mai, C. Voigt, Georg Berger, Andrea Spitzer |
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Dokumenttyp: | Zeitschriftenartikel |
Veröffentlichungsform: | Verlagsliteratur |
Sprache: | Englisch |
Titel des übergeordneten Werkes (Englisch): | Key engineering materials |
Jahr der Erstveröffentlichung: | 2002 |
Verlag: | Trans Tech Publ. |
Verlagsort: | Aedermannsdorf |
Jahrgang/Band: | 218-220 |
Erste Seite: | 307 |
Letzte Seite: | 310 |
Veranstaltung: | 14th International Symposium on Ceramics in Medicine |
Veranstaltungsort: | Palm Springs, CA, USA |
Beginndatum der Veranstaltung: | 2001-11-14 |
Enddatum der Veranstaltung: | 2001-11-17 |
DOI: | 10.4028/www.scientific.net/KEM.218-220.307 |
ISSN: | 1013-9826 |
Verfügbarkeit des Dokuments: | Physisches Exemplar in der Bibliothek der BAM vorhanden ("Hardcopy Access") |
Bibliotheksstandort: | Sonderstandort: Publica-Schrank |
Bibliotheksstandort: | Me 69 |
Datum der Freischaltung: | 19.02.2016 |
Referierte Publikation: | Ja |
Datum der Eintragung als referierte Publikation: | 10.12.2002 |