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High-repetition rate laser ablation coupled to dielectric barrier discharge postionization for ambient mass spectrometry

  • Most ambient sample introduction and ionization techniques for native mass spectrometry are highly selective for polar agents. To achieve a more general sensitivity for a wider range of target analytes, a novel laser ablation dielectric barrier discharge (LA DBD) ionization scheme was developed. The Approach employs a two-step mechanism with subsequent sample desorption and post-ionization. Effective Ablation was achieved by the second harmonic output (λ = 532 nm) of a diode pumped Nd:YVO₄ laser operating at a high-repetition rate of several kHz and pulse energies below 100 μJ. The ejected analytecontaining aerosol was consecutively vaporized and ionized in the afterglow of a DBD plasma jet. Depending on their proton affinity the superexcited Helium species in this afterglow produced analyte ions as protonated and ammoniated species, as well as radical cations. The optimization procedure could corroborate underlying conceptual consideration on the ablation, desorption and ionizationMost ambient sample introduction and ionization techniques for native mass spectrometry are highly selective for polar agents. To achieve a more general sensitivity for a wider range of target analytes, a novel laser ablation dielectric barrier discharge (LA DBD) ionization scheme was developed. The Approach employs a two-step mechanism with subsequent sample desorption and post-ionization. Effective Ablation was achieved by the second harmonic output (λ = 532 nm) of a diode pumped Nd:YVO₄ laser operating at a high-repetition rate of several kHz and pulse energies below 100 μJ. The ejected analytecontaining aerosol was consecutively vaporized and ionized in the afterglow of a DBD plasma jet. Depending on their proton affinity the superexcited Helium species in this afterglow produced analyte ions as protonated and ammoniated species, as well as radical cations. The optimization procedure could corroborate underlying conceptual consideration on the ablation, desorption and ionization mechanisms. A successful detection of a variety of target molecules could be shown from the pharmaceutical ibuprofen, urea, the amino acids L-arginine, L-lysine, the polymer polyethylene glycol, the organometallic compound ferrocene and the technical mixture wild mint oil. For a reliable evaluation of the introduced detection procedure spectra from the naturally abundant alkaloid capsaicin in dried capsicum fruits were recorded.zeige mehrzeige weniger

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Metadaten
Autor*innen:Andreas Bierstedt, Jens RiedelORCiD
Dokumenttyp:Zeitschriftenartikel
Veröffentlichungsform:Verlagsliteratur
Sprache:Englisch
Titel des übergeordneten Werkes (Englisch):Methods
Jahr der Erstveröffentlichung:2016
Verlag:Elsevier
Verlagsort:Oxford
Ausgabe/Heft:104
Erste Seite:3
Letzte Seite:10
DDC-Klassifikation:Naturwissenschaften und Mathematik / Chemie / Analytische Chemie
Freie Schlagwörter:Ambient mass spectrometry; Dielectric barrier discharge; High-repetition rate laser; Laser ablation
DOI:10.1016/j.ymeth.2016.02.002
ISSN:1046-2023
Verfügbarkeit des Dokuments:Datei im Netzwerk der BAM verfügbar ("Closed Access")
Datum der Freischaltung:04.07.2016
Referierte Publikation:Ja
Datum der Eintragung als referierte Publikation:30.08.2016
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