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Integrating fluorescent molecularly imprinted polymer (MIP) sensor particles with a modular microfluidic platform for the detection of the herbicide 2,4-D

  • 2,4-Dichlorophenoxyacetic acid (2,4-D) is an important and well-known herbicide that is widely used in agriculture because of its advantages to regulate plant growth.1 However, the use of large quantities of the treated plants as animal feed leads to residues in meat, milk and eggs. Furthermore, the herbicide can drain off and contaminate ground and drinking water. The ingestion of 2,4-D-contaminated food and water can cause damage to the inner organs of humans and animals, e.g., the kidneys and the liver. Analytical assays based on molecularly imprinted polymers (MIPs) have emerged as a valuable tool in the field of environmental analysis due to the low production costs, high stability, format adaptability and the possibility to imprint—and thus their ability to recognize—a wide variety of target analytes. Regarding optical sensing technologies, however, MIPs have only been used in considerably few applications, especially in fluorescence sensors. This limitation is basically because2,4-Dichlorophenoxyacetic acid (2,4-D) is an important and well-known herbicide that is widely used in agriculture because of its advantages to regulate plant growth.1 However, the use of large quantities of the treated plants as animal feed leads to residues in meat, milk and eggs. Furthermore, the herbicide can drain off and contaminate ground and drinking water. The ingestion of 2,4-D-contaminated food and water can cause damage to the inner organs of humans and animals, e.g., the kidneys and the liver. Analytical assays based on molecularly imprinted polymers (MIPs) have emerged as a valuable tool in the field of environmental analysis due to the low production costs, high stability, format adaptability and the possibility to imprint—and thus their ability to recognize—a wide variety of target analytes. Regarding optical sensing technologies, however, MIPs have only been used in considerably few applications, especially in fluorescence sensors. This limitation is basically because the incorporation of a fluorescently responding moiety into a polymer matrix is challenging. One way to overcome this limitation is to use tailor-made fluorescent indicator monomers or cross-linkers for direct transfer of the binding event into an optical signal and to coat the MIP via reversible addition-fragmentation chain transfer (RAFT) polymerization as a thin layer onto the surface of silica nanoparticles as primary sensing element. Here, we present the response behaviour of fluorescent MIP sensor particles in terms of sensitivity for 2,4-D detection (the so-called imprinting factor), discrimination ability against structurally similar compounds (the discrimination factor) and performance in a phase-transfer assay (PTA) on chip, i.e., the implementation of the assay into a microfluidic chip environment, offering a novel simple and rapid way for the detection of herbicides in water.zeige mehrzeige weniger

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Metadaten
Autor*innen:Sabine Wagner
Koautor*innen:Jérémy Bell, Mustafa Biyikal, Kornelia Gawlitza, Knut Rurack
Dokumenttyp:Vortrag
Veröffentlichungsform:Präsentation
Sprache:Englisch
Jahr der Erstveröffentlichung:2017
DDC-Klassifikation:Technik, Medizin, angewandte Wissenschaften / Ingenieurwissenschaften / Ingenieurwissenschaften und zugeordnete Tätigkeiten
Freie Schlagwörter:2,4-Dichlorophenoxyacetic acid; Microfluidic device; Molecularly imprinted polymers
Veranstaltung:GSSMIP2017
Veranstaltungsort:Porto, Portugal
Beginndatum der Veranstaltung:08.06.2017
Enddatum der Veranstaltung:09.06.2017
Verfügbarkeit des Dokuments:Datei im Netzwerk der BAM verfügbar ("Closed Access")
Datum der Freischaltung:14.06.2017
Referierte Publikation:Nein
Eingeladener Vortrag:Nein
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