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Analytical insights at the point-of-need with antibody-based methods

  • A vast number of emerging pollutants is being detected in the environment. Another lingering problem are health-threatening contaminants, such as mycotoxins, that deteriorate food and feed. Analytical methods, suitable for trace analysis, are needed that are desirably also fast, inexpensive and, if possible, robust, and portable. Immunoanalytical, i.e., antibody-based methods, which are available in a broad range of formats, can be profitably used here to analyze for the distribution and the concen-tration trends of contaminants. Some of these formats are single-analyte but high-throughput methods. To use them wisely, indicator substances or sum parameters are being established and used in screening approaches. Other methods are suitable to be performed on portable instrumentation in the field (on-site), more precisely at the point-of-need. Furthermore, there are array technologies that allow for parallel analysis of several analytes of interest (multiplexing). The talk reports onA vast number of emerging pollutants is being detected in the environment. Another lingering problem are health-threatening contaminants, such as mycotoxins, that deteriorate food and feed. Analytical methods, suitable for trace analysis, are needed that are desirably also fast, inexpensive and, if possible, robust, and portable. Immunoanalytical, i.e., antibody-based methods, which are available in a broad range of formats, can be profitably used here to analyze for the distribution and the concen-tration trends of contaminants. Some of these formats are single-analyte but high-throughput methods. To use them wisely, indicator substances or sum parameters are being established and used in screening approaches. Other methods are suitable to be performed on portable instrumentation in the field (on-site), more precisely at the point-of-need. Furthermore, there are array technologies that allow for parallel analysis of several analytes of interest (multiplexing). The talk reports on methods and data for compounds considered as anthropogenic contamination markers (the antiepileptic carbamazepine, the analgesic diclofenac, the anti-histaminic cetirizine, the steroid hormone estrone, the antimicrobial amoxicillin, the stimulants caffeine and cocaine, the endo-crine disruptor bisphenol A, and a bile acid). Some work on mycotoxins (ochratoxin A and ergot alka-loids) is also presented. It is demonstrated that antibody-based approaches have a huge potential to gain analytical insights at the point-of-need.zeige mehrzeige weniger

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Metadaten
Autor*innen:Rudolf SchneiderORCiD
Dokumenttyp:Vortrag
Veröffentlichungsform:Präsentation
Sprache:Englisch
Jahr der Erstveröffentlichung:2021
Organisationseinheit der BAM:1 Analytische Chemie; Referenzmaterialien
1 Analytische Chemie; Referenzmaterialien / 1.8 Umweltanalytik
DDC-Klassifikation:Naturwissenschaften und Mathematik / Chemie / Analytische Chemie
Technik, Medizin, angewandte Wissenschaften / Ingenieurwissenschaften / Sanitär- und Kommunaltechnik; Umwelttechnik
Freie Schlagwörter:Biosensoren; Point-of-Care; Schnelltests; Vor-Ort-Analytik
Themenfelder/Aktivitätsfelder der BAM:Umwelt
Umwelt / Sensorik
Veranstaltung:empa - Seminar of the Laboratory of Advanced Analytical Technologies
Veranstaltungsort:Online meeting
Beginndatum der Veranstaltung:24.11.2021
Enddatum der Veranstaltung:24.11.2021
Verfügbarkeit des Dokuments:Datei im Netzwerk der BAM verfügbar ("Closed Access")
Datum der Freischaltung:15.12.2021
Referierte Publikation:Nein
Eingeladener Vortrag:Nein
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