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Health effects of laser printer emissions: a controlled exposure study

  • Ultrafine particles emitted from laser printers are suspected to elicit adverse health effects. We performed 75-minute exposures to emissions of laser printing devices (LPDs) in a standardized, randomized, cross- over manner in 23 healthy subjects, 14 mild, stable asthmatics, and 15 persons reporting symptoms associated with LPD emissions. Low-level exposures (LLE) ranged at the particle background (3000 cm−3) and High-level exposures (HLE) at 100 000 cm−3. Examinations before and after exp sures included spirometry, body plethysmography, transfer factors for CO and NO (TLCO, TLNO), bronchial and alveolar NO, cytokines in serum and nasal secretions (IL-1β, IL-5, IL-6, IL-8, GM-CSF, IFNγ, TNFα), serum ECP, and IgE. Across all participants, no statistically significant changes occurred for lung mechanics and NO. There was a decrease in volume-related TLNO that was more pronounced in HLE, but the difference to LLE was not significant. ECP and IgE increased in the same way afterUltrafine particles emitted from laser printers are suspected to elicit adverse health effects. We performed 75-minute exposures to emissions of laser printing devices (LPDs) in a standardized, randomized, cross- over manner in 23 healthy subjects, 14 mild, stable asthmatics, and 15 persons reporting symptoms associated with LPD emissions. Low-level exposures (LLE) ranged at the particle background (3000 cm−3) and High-level exposures (HLE) at 100 000 cm−3. Examinations before and after exp sures included spirometry, body plethysmography, transfer factors for CO and NO (TLCO, TLNO), bronchial and alveolar NO, cytokines in serum and nasal secretions (IL-1β, IL-5, IL-6, IL-8, GM-CSF, IFNγ, TNFα), serum ECP, and IgE. Across all participants, no statistically significant changes occurred for lung mechanics and NO. There was a decrease in volume-related TLNO that was more pronounced in HLE, but the difference to LLE was not significant. ECP and IgE increased in the same way after exposures. Nasal IL-6 showed a higher increase after LLE. There was no coherent pattern regarding the responses in the participant subgroups or single sets of variables. In conclusion, the experimental acute responses to short but very high-level LPD exposures were small and did not indicate clinically relevant effects compared to low particle number concentrations.zeige mehrzeige weniger

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Metadaten
Autoren/innen:Stefan Karrasch, M. Simon, Britta Herbig, Jeanette Langner, Stefan Seeger, A. Kronseder, S. Peters, G. Dietrich-Gümperlein, R. Schierl, D. Nowak, R.A. Jörres
Persönliche Herausgeber/innen:William Nazaroff
Dokumenttyp:Zeitschriftenartikel
Veröffentlichungsform:Verlagsliteratur
Sprache:Englisch
Titel des übergeordneten Werkes (Englisch):Indoor Air
Jahr der Erstveröffentlichung:2017
Organisationseinheit der BAM:4 Material und Umwelt
4 Material und Umwelt / 4.2 Materialien und Luftschadstoffe
Herausgeber (Institution):International Society of Indoor Air Quality and Climate
Verlag:John Wiley & Sons Ltd.
Verlagsort:London
Jahrgang/Band:27
Ausgabe/Heft:4
Erste Seite:753
Letzte Seite:765
DDC-Klassifikation:Technik, Medizin, angewandte Wissenschaften / Ingenieurwissenschaften / Sanitär- und Kommunaltechnik; Umwelttechnik
Freie Schlagwörter:Emission; Exposure; Laser printer; Lung function; Respiratory health; Ultrafine particles
Themenfelder/Aktivitätsfelder der BAM:Umwelt
DOI:https://doi.org/10.1111/ina.12366
URL:http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS&DestLinkType=FullRecord;UT=WOS:000403895400006
ISSN:1600-0668
Verfügbarkeit des Dokuments:Datei im Netzwerk der BAM verfügbar ("Closed Access")
Datum der Freischaltung:23.10.2017
Referierte Publikation:Ja
Datum der Eintragung als referierte Publikation:23.10.2017