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Characterisation of an inexpensive sonic spray ionisation source using laser induced fluorescence imaging and mass spectrometry

  • A commercially available airbrush gun as a new source for spray ionization is presented. It is best operated employing moderate stagnation pressures, resulting in a sonic gas flow. A mass spectrometric investigation on the amino acid lysine and several peptides reveals that this inexpensive approach results in reproducible mass spectra. The ion patterns strongly resemble the results from other studies obtained with custom made sonic spray vaporizers. The patterns as well resemble the mass spectra recorded with electrospray devices. For a better understanding of the vaporization process, the mass spectrometry experiments are accompanied by laser induced fluorescence experiments. Inverse Abel transform of the obtained fluorescence maps allows the determination of the full 3D distribution of the spray cone. Furthermore, via exploitation of the solvatochromism of the used dye the solvation state distribution can be visualized. In addition, expansion parameters like droplet size andA commercially available airbrush gun as a new source for spray ionization is presented. It is best operated employing moderate stagnation pressures, resulting in a sonic gas flow. A mass spectrometric investigation on the amino acid lysine and several peptides reveals that this inexpensive approach results in reproducible mass spectra. The ion patterns strongly resemble the results from other studies obtained with custom made sonic spray vaporizers. The patterns as well resemble the mass spectra recorded with electrospray devices. For a better understanding of the vaporization process, the mass spectrometry experiments are accompanied by laser induced fluorescence experiments. Inverse Abel transform of the obtained fluorescence maps allows the determination of the full 3D distribution of the spray cone. Furthermore, via exploitation of the solvatochromism of the used dye the solvation state distribution can be visualized. In addition, expansion parameters like droplet size and velocity are obtained by laser stroboscopy. The experiments demonstrate that the analyte is hardly desolvated throughout the expansion. This indicates a subsequent vaporization of the residual solvent in the intermediate pressure region of the mass spectrometer.zeige mehrzeige weniger

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Metadaten
Autor*innen:Arne Stindt, Carsten Warschat, Andreas Bierstedt, Ulrich PanneORCiD, Jens RiedelORCiD
Dokumenttyp:Zeitschriftenartikel
Veröffentlichungsform:Verlagsliteratur
Sprache:Englisch
Titel des übergeordneten Werkes (Englisch):European journal of mass spectrometry
Jahr der Erstveröffentlichung:2014
Verlag:IM Publications
Verlagsort:Chichester
Jahrgang/Band:20
Ausgabe/Heft:1
Erste Seite:21
Letzte Seite:29
Freie Schlagwörter:Airbrush; Inverse Abel Transform; Laser induced fluorescence; Mass spectrometry; Solvatochromism; Sonic spray; Sonic spray ionization
DOI:10.1255/ejms.1242
ISSN:1469-0667
ISSN:1356-1049
ISSN:1365-0718
Verfügbarkeit des Dokuments:Physisches Exemplar in der Bibliothek der BAM vorhanden ("Hardcopy Access")
Bibliotheksstandort:Sonderstandort: Publica-Schrank
Datum der Freischaltung:20.02.2016
Referierte Publikation:Ja
Datum der Eintragung als referierte Publikation:24.03.2014
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