Solvent-triggered crystallization of polymorphs studied in situ
- The crystallization of a highly polymorphic compound was studied in situ by combined time-resolved X-ray diffraction and Raman spectroscopy. Any influences of solid surfaces, temperature, and humidity on the crystallization were omitted by the use of a specially designed acoustic levitator. Investigations of polymorphic phase transitions during the crystallization process in different solvents allowed a structure assignment from first crystalline assemblies to final crystalline form. For the first time, it was possible to yield pure phases of selected polymorphs of the model compound ROY (5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile) directly from solution. The influence of the solvent on the final products and transient phases during the crystallization process was elucidated.
Autor*innen: | Tanja Gnutzmann, Thi Yen Nguyen, K. Rademann, Franziska EmmerlingORCiD |
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Dokumenttyp: | Zeitschriftenartikel |
Veröffentlichungsform: | Verlagsliteratur |
Sprache: | Englisch |
Titel des übergeordneten Werkes (Englisch): | Crystal growth & design |
Jahr der Erstveröffentlichung: | 2014 |
Herausgeber (Institution): | American Chemical Society |
Verlag: | American Chemical Society |
Verlagsort: | Washington, DC, USA |
Jahrgang/Band: | 14 |
Ausgabe/Heft: | 12 |
Erste Seite: | 6445 |
Letzte Seite: | 6450 |
Freie Schlagwörter: | Crystallization; In situ Raman spectroscopy; In situ WAXS; Polymorphism; ROY |
DOI: | 10.1021/cg501287v |
ISSN: | 1528-7483 |
Verfügbarkeit des Dokuments: | Datei im Netzwerk der BAM verfügbar ("Closed Access") |
Datum der Freischaltung: | 20.02.2016 |
Referierte Publikation: | Ja |
Datum der Eintragung als referierte Publikation: | 19.02.2015 |