“Click” analytics for “click” chemistry – a simple method for calibration-free evaluation of online NMR spectra
- Currently research in chemical manufacturing moves towards flexible plug-and-play approaches focusing on modular plants, capable of producing small scales on-demand with short down-times between individual cam-paigns. This approach allows for efficient use of hardware, a faster optimization of the process conditions, and thus, an accelerated introduction of new products to the market. Driven mostly by the search for chemical syntheses under biocompatible conditions, so-called “click” chemistry rapidly became a growing field of research. The re-sulting simple one-pot reactions are so far only scarcely accompanied by an adequate optimization via compara-bly straightforward and robust analysis techniques. Here we report on a fast and reliable calibration-free online high field NMR monitoring approach for technical mixtures. It combines a versatile fluidic system, continuous-flow measurement with a time interval of 20 s per spectrum, and a robust, automated algo-rithm to interpret theCurrently research in chemical manufacturing moves towards flexible plug-and-play approaches focusing on modular plants, capable of producing small scales on-demand with short down-times between individual cam-paigns. This approach allows for efficient use of hardware, a faster optimization of the process conditions, and thus, an accelerated introduction of new products to the market. Driven mostly by the search for chemical syntheses under biocompatible conditions, so-called “click” chemistry rapidly became a growing field of research. The re-sulting simple one-pot reactions are so far only scarcely accompanied by an adequate optimization via compara-bly straightforward and robust analysis techniques. Here we report on a fast and reliable calibration-free online high field NMR monitoring approach for technical mixtures. It combines a versatile fluidic system, continuous-flow measurement with a time interval of 20 s per spectrum, and a robust, automated algo-rithm to interpret the ob-tained data. All spectra were acquired using a 500 MHz NMR spectrometer (Varian) with a dual band flow probe having a 1/16 inch polymer tubing working as a flow cell. Single scan 1H spectra were recorded with an acquisition time of 5 s, relaxation delay of 15 s.…
Autor*innen: | Simon KernORCiD, Aleksandra Michalik-Onichimowska, Jens RiedelORCiD, Ulrich PanneORCiD, Rudibert King, Michael MaiwaldORCiD |
---|---|
Persönliche Herausgeber*innen: | Michael MaiwaldORCiD |
Dokumenttyp: | Beitrag zu einem Tagungsband |
Veröffentlichungsform: | Graue Literatur |
Sprache: | Englisch |
Titel des übergeordneten Werkes (Englisch): | Tagungsband – 12. Kolloquium Prozessanalytik, Berlin, 28.–30. November 2016 |
Jahr der Erstveröffentlichung: | 2016 |
Erste Seite: | 72 |
Letzte Seite: | 74 |
DDC-Klassifikation: | Naturwissenschaften und Mathematik / Chemie / Analytische Chemie |
Freie Schlagwörter: | Online NMR; Online monitoring; “Click” chemistry |
Veranstaltung: | 12. Kolloquium des Arbeitskreises Prozessanalytik |
Veranstaltungsort: | Berlin, Germany |
Beginndatum der Veranstaltung: | 28.11.2016 |
Enddatum der Veranstaltung: | 30.11.2016 |
Verfügbarkeit des Dokuments: | Datei im Netzwerk der BAM verfügbar ("Closed Access") |
Datum der Freischaltung: | 22.11.2016 |
Referierte Publikation: | Nein |