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“Click” analytics for “click” chemistry – a simple method for calibration-free evaluation of online NMR spectra

  • Currently research in chemical manufacturing moves towards flexible plug-and-play approaches focusing on modular plants, capable of producing small scales ondemand with short down-times between individual campaigns. This approach allows for efficient use of hardware, a faster optimization of the process conditions, and thus, an accelerated introduction of new products to the market. Driven mostly by the search for chemical syntheses under biocompatible conditions, so-called “click” chemistry rapidly became a growing field of research. The resulting simple one-pot reactions are so far only scarcely accompanied by an adequate optimization via comparably straightforward and robust analysis techniques. Here we report on a fast and reliable calibration-free online high field NMR monitoring approach for technical mixtures. It combines a versatile fluidic system, continuous-flow measurement with a time interval of 20 s per spectrum, and a robust, automated algorithm to interpret the obtainedCurrently research in chemical manufacturing moves towards flexible plug-and-play approaches focusing on modular plants, capable of producing small scales ondemand with short down-times between individual campaigns. This approach allows for efficient use of hardware, a faster optimization of the process conditions, and thus, an accelerated introduction of new products to the market. Driven mostly by the search for chemical syntheses under biocompatible conditions, so-called “click” chemistry rapidly became a growing field of research. The resulting simple one-pot reactions are so far only scarcely accompanied by an adequate optimization via comparably straightforward and robust analysis techniques. Here we report on a fast and reliable calibration-free online high field NMR monitoring approach for technical mixtures. It combines a versatile fluidic system, continuous-flow measurement with a time interval of 20 s per spectrum, and a robust, automated algorithm to interpret the obtained data. All spectra were acquired using a 500 MHz NMR spectrometer (Varian) with a dual band flow probe having a 1/16 inch polymer tubing working as a flow cell. Single scan 1H spectra were recorded with an acquisition time of 5 s, relaxation delay of 15 s. As a proof-of-concept, the thiol-ene coupling between N-boc cysteine methyl ester and allyl alcohol was conducted in non-deuterated solvents while its time-resolved behaviour was characterised with step tracer experiments Through the application of spectral modeling the signal area for each reactant can be deconvoluted in the online spectra and thus converted to the respective concentrations or molar ratios. The signals which were suitable for direct integration were used herein for comparison purposes of both methods.zeige mehrzeige weniger

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  • EuroPACT_2017_Kern_et_al_156-157.pdf
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  • BoA_EuroPACT_2017_titel.pdf
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Metadaten
Autor*innen:Simon KernORCiD, Aleksandra Michalik-Onichimowska, Jens RiedelORCiD, Ulrich PanneORCiD, R. King, Michael MaiwaldORCiD
Dokumenttyp:Beitrag zu einem Tagungsband
Veröffentlichungsform:Graue Literatur
Sprache:Englisch
Titel des übergeordneten Werkes (Englisch):Processdings of 4th European Conference on Process Analytics and Control Technology (EuroPACT 2017)
Jahr der Erstveröffentlichung:2017
Herausgeber (Institution):DECHEMA e. V., Frankfurt
Verlagsort:Frankfurt a. M.
Erste Seite:156
Letzte Seite:157
DDC-Klassifikation:Naturwissenschaften und Mathematik / Chemie / Analytische Chemie
Freie Schlagwörter:Click Chemistry; Indirect Hard Modeling; Online NMR Spectroscopy; Process Analytical Technology; Process control; Reaction Monitoring; Spectral Modeling
Veranstaltung:4th European Conference on Process Analytics and Control Technology (EuroPACT 2017)
Veranstaltungsort:Potsdam, Germany
Beginndatum der Veranstaltung:10.05.2017
Enddatum der Veranstaltung:12.05.2017
Verfügbarkeit des Dokuments:Datei im Netzwerk der BAM verfügbar ("Closed Access")
Datum der Freischaltung:15.05.2017
Referierte Publikation:Nein
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