Zitieren Sie bitte immer diesen URN: urn:nbn:de:kobv:b43-480623
Flexible automation with compact NMR spectroscopy for continuous production of pharmaceuticals
- Modular plants using intensified continuous processes represent an appealing concept for the production of pharmaceuticals. It can improve quality, safety, sustainability, and profitability compared to batch processes; besides, it enables plug-and-produce reconfiguration for fast product changes. To facilitate this flexibility by real-time quality control, we developed a solution that can be adapted quickly to new processes and is based on a compact nuclear magnetic resonance (NMR) spectrometer. The NMR sensor is a benchtop device enhanced to the requirements of automated chemical production including robust evaluation of sensor data. Beyond monitoring the product quality, online NMR data was used in a new iterative optimization approach to maximize the plant profit and served as a reliable reference for the calibration of a near-infrared (NIR) spectrometer. The overall approach was demonstrated on a commercial-scale pilot plant using a metal-organic reaction with pharmaceuticalModular plants using intensified continuous processes represent an appealing concept for the production of pharmaceuticals. It can improve quality, safety, sustainability, and profitability compared to batch processes; besides, it enables plug-and-produce reconfiguration for fast product changes. To facilitate this flexibility by real-time quality control, we developed a solution that can be adapted quickly to new processes and is based on a compact nuclear magnetic resonance (NMR) spectrometer. The NMR sensor is a benchtop device enhanced to the requirements of automated chemical production including robust evaluation of sensor data. Beyond monitoring the product quality, online NMR data was used in a new iterative optimization approach to maximize the plant profit and served as a reliable reference for the calibration of a near-infrared (NIR) spectrometer. The overall approach was demonstrated on a commercial-scale pilot plant using a metal-organic reaction with pharmaceutical relevance.…
Autor*innen: | Simon KernORCiD, Lukas WanderORCiD, Klas MeyerORCiD, Svetlana Guhl, A. R. Gottu Mukkula, M. Holtkamp, M. Salge, C. Fleischer, N. Weber, S. Engell, Andrea PaulORCiD, M. Pereira Remelhe, Michael MaiwaldORCiD |
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Dokumenttyp: | Zeitschriftenartikel |
Veröffentlichungsform: | Verlagsliteratur |
Sprache: | Englisch |
Titel des übergeordneten Werkes (Englisch): | Analytical and Bioanalytical Chemistry |
Jahr der Erstveröffentlichung: | 2019 |
Organisationseinheit der BAM: | 1 Analytische Chemie; Referenzmaterialien |
1 Analytische Chemie; Referenzmaterialien / 1.4 Prozessanalytik | |
Veröffentlichende Institution: | Bundesanstalt für Materialforschung und -prüfung (BAM) |
Verlag: | Springer Nature |
Verlagsort: | Heidelberg |
Jahrgang/Band: | 411 |
Ausgabe/Heft: | 14 |
Erste Seite: | 3037 |
Letzte Seite: | 3046 |
DDC-Klassifikation: | Naturwissenschaften und Mathematik / Chemie / Analytische Chemie |
Freie Schlagwörter: | CONSENS; Continuous processes; Data Fusion; NIR Spectroscopy; NMR Spectroscopy; Real-time process monitoring; Real-time quality control |
Themenfelder/Aktivitätsfelder der BAM: | Chemie und Prozesstechnik |
Chemie und Prozesstechnik / Chemische Charakterisierung und Spurenanalytik | |
Umwelt | |
Umwelt / Sensorik | |
DOI: | 10.1007/s00216-019-01752-y |
URN: | urn:nbn:de:kobv:b43-480623 |
ISSN: | 1618-2642 |
ISSN: | 1618-2650 |
Zugehöriger Identifikator: | https://nbn-resolving.org/urn:nbn:de:kobv:b43-480630 |
Verfügbarkeit des Dokuments: | Datei für die Öffentlichkeit verfügbar ("Open Access") |
Lizenz (Deutsch): | Creative Commons - CC BY - Namensnennung 4.0 International |
Datum der Freischaltung: | 27.05.2019 |
Referierte Publikation: | Ja |
Datum der Eintragung als referierte Publikation: | 27.05.2019 |
Schriftenreihen ohne Nummerierung: | Wissenschaftliche Artikel der BAM |