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Design and validation of an additively manufactured flowCell–static mixer combination for inline NMR spectroscopy

  • There have been an increasing number of publications on flow chemistry applications of compact NMR. Despite this, there is so far no comprehensive workflow for the technical design of flow cells. Here, we present an approach that is suitable for the design of an NMR flow cell with an integrated static mixing unit. This design moves the mixing of reactants to the active NMR detection region within the NMR instrument, presenting a feature that analyses chemical reactions faster (5–120 s region) than other common setups. During the design phase, the targeted mixing homogeneity of the components was evaluated for different types of mixing units based on CFD simulation. Subsequently, the flow cell was additively manufactured from ceramic material and metal tubing. Within the targeted working mass flow range, excellent mixing properties as well as narrow line widths were confirmed in validation experiments, comparable to common glassThere have been an increasing number of publications on flow chemistry applications of compact NMR. Despite this, there is so far no comprehensive workflow for the technical design of flow cells. Here, we present an approach that is suitable for the design of an NMR flow cell with an integrated static mixing unit. This design moves the mixing of reactants to the active NMR detection region within the NMR instrument, presenting a feature that analyses chemical reactions faster (5–120 s region) than other common setups. During the design phase, the targeted mixing homogeneity of the components was evaluated for different types of mixing units based on CFD simulation. Subsequently, the flow cell was additively manufactured from ceramic material and metal tubing. Within the targeted working mass flow range, excellent mixing properties as well as narrow line widths were confirmed in validation experiments, comparable to common glass tubes.zeige mehrzeige weniger

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Metadaten
Autoren/innen:Martin Bornemann, Simon Kern, N. Jurtz, Tobias Thiede, M. Kraume, Michael Maiwald
Dokumenttyp:Zeitschriftenartikel
Veröffentlichungsform:Verlagsliteratur
Sprache:Englisch
Titel des übergeordneten Werkes (Englisch):Industrial & Engineering Chemistry Research
Jahr der Erstveröffentlichung:2019
Organisationseinheit der BAM:1 Analytische Chemie; Referenzmaterialien
1 Analytische Chemie; Referenzmaterialien / 1.4 Prozessanalytik
8 Zerstörungsfreie Prüfung
8 Zerstörungsfreie Prüfung / 8.5 Mikro-ZfP
Verlag:American Chemical Society
Verlagsort:Washington
Jahrgang/Band:58
Erste Seite:19562
Letzte Seite:19570
DDC-Klassifikation:Naturwissenschaften und Mathematik / Chemie / Analytische Chemie
Technik, Medizin, angewandte Wissenschaften / Ingenieurwissenschaften / Ingenieurwissenschaften und zugeordnete Tätigkeiten
Freie Schlagwörter:Flow Chemistry; Inline NMR Spectroscopy; Integrated Processes; Modular Production; Process Analytical Technology; Reaction Monitoring; Static Mixing
Themenfelder/Aktivitätsfelder der BAM:Material
Material / Materialien und Stoffe
Analytical Sciences
Analytical Sciences / Spurenanalytik und chemische Zusammensetzung
Analytical Sciences / Sensorik
DOI:https://doi.org/10.1021/acs.iecr.9b03746
URL:https://pubs.acs.org/doi/abs/10.1021/acs.iecr.9b03746
ISSN:0888-5885
ISSN:1520-5045
Verfügbarkeit des Dokuments:Datei im Netzwerk der BAM verfügbar ("Closed Access")
Datum der Freischaltung:23.09.2019
Referierte Publikation:Nein