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Integrating fluorescent molecularly imprinted polymer (MIP) sensor particles with a microfluidic platform for nanomolar small-molecule detection in water

  • Besides the traditional areas of application such as separation and enrichment which made molecularly imprinted polymers (MIPs) very attractive, they have emerged as a valuable detection tool in the field of environmental analysis due to the low production costs, high stability, format adaptability and the possibility to imprint and thus specifically recognize a wide variety of target analytes. Regarding optical sensing, however, MIPs have only been used in considerably few applications, especially in fluorescence sensors, basically because of the challenge to incorporate a fluorescently responding moiety into a polymer matrix. One way to overcome this limitation is the coating of a thin MIP layer onto the surface of silica nanoparticles using tailor-made fluorescent indicator monomers or cross-linkers for direct transfer of the binding event into an optical signal. Regarding sensors for environmental monitoring, microfluidic devices utilizing optical detection modules are especiallyBesides the traditional areas of application such as separation and enrichment which made molecularly imprinted polymers (MIPs) very attractive, they have emerged as a valuable detection tool in the field of environmental analysis due to the low production costs, high stability, format adaptability and the possibility to imprint and thus specifically recognize a wide variety of target analytes. Regarding optical sensing, however, MIPs have only been used in considerably few applications, especially in fluorescence sensors, basically because of the challenge to incorporate a fluorescently responding moiety into a polymer matrix. One way to overcome this limitation is the coating of a thin MIP layer onto the surface of silica nanoparticles using tailor-made fluorescent indicator monomers or cross-linkers for direct transfer of the binding event into an optical signal. Regarding sensors for environmental monitoring, microfluidic devices utilizing optical detection modules are especially appealing because of their versatility in terms of miniaturization and automation. So far, MIPs have only rarely been used in combination with microfluidic sensor devices. Here, we present the hydrogen bond-mediated optical response of fluorescent MIP sensor particles against a typical small-molecule analyte 2,4-D (2,4-dichlorophen¬oxyacetic acid) which is an important herbicide widely used in agriculture and known to cause adverse health effects when ingested by contaminated water. By combining the sensor particles with droplet-based 3D microfluidics, a microfluidic phase-transfer assay was designed which enables the direct analysis of 2,4-D in river and lake water without sample pre-treatment or clean-up.zeige mehrzeige weniger

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Metadaten
Autor*innen:Kornelia GawlitzaORCiD
Koautor*innen:Sabine Wagner, Jérémy Bell, Mustafa Biyikal, Knut Rurack
Dokumenttyp:Posterpräsentation
Veröffentlichungsform:Präsentation
Sprache:Englisch
Jahr der Erstveröffentlichung:2017
DDC-Klassifikation:Technik, Medizin, angewandte Wissenschaften / Ingenieurwissenschaften / Sanitär- und Kommunaltechnik; Umwelttechnik
Freie Schlagwörter:Fluorescence; MIPs; Sensor; Water-monitoring
Veranstaltung:Bioinspired Materials conference 2017
Veranstaltungsort:Manchester, UK
Beginndatum der Veranstaltung:31.08.2017
Enddatum der Veranstaltung:01.09.2017
Verfügbarkeit des Dokuments:Datei im Netzwerk der BAM verfügbar ("Closed Access")
Datum der Freischaltung:04.09.2017
Referierte Publikation:Nein
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