Reference measurement procedure for Delta9-tetrahydrocannabinol in serum
- An isotope dilution gas chromatography/mass spectrometry (ID-GC/MS) reference measurement procedure for Δ9-tetrahydrocannabinol (THC) in serum was developed and validated. The method complies with the concept of a ratio primary reference measurement procedure. The uncertainty was determined for two concentrations of THC in serum (1 ng/mL and 2.4 ng/mL). The calculation procedure is based on the Guide to the Expression of Uncertainty in Measurement (GUM). The relative expanded uncertainty was found to be less than 2% for both concentration levels, corresponding to a 95% confidence interval. For the reference method, it was shown that the measurement of THC within the concentration range covered by the current threshold values is very accurate. The method has the potential to provide traceability for the methods used in practical forensics.
Autor*innen: | S. Lott, A. Henrion, Frank Malz, A. Kessler, B. Güttler, R. Aderjan |
---|---|
Dokumenttyp: | Zeitschriftenartikel |
Veröffentlichungsform: | Verlagsliteratur |
Sprache: | Englisch |
Titel des übergeordneten Werkes (Englisch): | Analytical and bioanalytical chemistry |
Jahr der Erstveröffentlichung: | 2008 |
Verlag: | Springer |
Verlagsort: | Berlin |
Jahrgang/Band: | 391 |
Ausgabe/Heft: | 3 |
Erste Seite: | 1003 |
Letzte Seite: | 1010 |
Freie Schlagwörter: | GUM; Primary method; Quantitative NMR; Reference material; THC; Threshold value; Uncertainty of measurement |
DOI: | 10.1007/s00216-008-2065-1 |
ISSN: | 1618-2642 |
ISSN: | 1618-2650 |
Verfügbarkeit des Dokuments: | Physisches Exemplar in der Bibliothek der BAM vorhanden ("Hardcopy Access") |
Bibliotheksstandort: | Sonderstandort: Publica-Schrank |
Datum der Freischaltung: | 19.02.2016 |
Referierte Publikation: | Ja |
Datum der Eintragung als referierte Publikation: | 23.06.2008 |