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Mass fraction assignment of folic acid in a high purity material - CCQM-K55.d (Folic acid) Final Report

  • The comparison required the assignment of the mass fraction of folic acid present as the main component in the comparison sample. Performance in the comparison is representative of a laboratory's measurement capability for the purity assignment of organic compounds of medium structural complexity [molecular weight range 300–500] and high polarity (pKOW < −2). Methods used by the eighteen participating NMIs or DIs were based on a mass balance (summation of impurities) or qNMR approach, or the combination of data obtained using both methods. The qNMR results tended to give slightly lower values for the content of folic acid, albeit with larger associated uncertainties, compared with the results obtained by mass balance procedures. Possible reasons for this divergence are discussed in the report, without reaching a definitive conclusion as to their origin. The comparison demonstrates that for a structurally complex polar organic compound containing a high water content and presenting aThe comparison required the assignment of the mass fraction of folic acid present as the main component in the comparison sample. Performance in the comparison is representative of a laboratory's measurement capability for the purity assignment of organic compounds of medium structural complexity [molecular weight range 300–500] and high polarity (pKOW < −2). Methods used by the eighteen participating NMIs or DIs were based on a mass balance (summation of impurities) or qNMR approach, or the combination of data obtained using both methods. The qNMR results tended to give slightly lower values for the content of folic acid, albeit with larger associated uncertainties, compared with the results obtained by mass balance procedures. Possible reasons for this divergence are discussed in the report, without reaching a definitive conclusion as to their origin. The comparison demonstrates that for a structurally complex polar organic compound containing a high water content and presenting a number of additional analytical challenges, the assignment of the mass fraction content property value of the main component can reasonably be achieved with an associated relative standard uncertainty in the assigned value of 0.5%zeige mehrzeige weniger

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Metadaten
Autoren/innen:S. Westwood, R. Josephs, T. Choteau, A. Daireaux, N. Stoppacher, R. Wielgosz, S. Davies, E. do Rego, W. Wollinger, B. Garrido, J. Fernandes, J. Lima, R. Oliveira, R. de Sena, A. Windust, T. Huang, X. Dai, C. Quan, H. He, W. Zhang, C. Wei, N. Li, D. Gao, Z. Liu, M. Lo, W. Wong, Dietmar Pfeifer, Matthias Koch, Ute Dorgerloh, Robert Rothe, Rosemarie Philipp, N. Hanari, M. Rezali, C. Arzate, M. Berenice, V. Caballero, M. Osuna, A. Krylov, S. Kharitonov, E. Lopushanskaya, Q. Liu, T. Lin, M. Fernandes-Whaley, L. Quinn, N. Nhlapo, D. Prevoo-Franzsen, M. Archer, B. Kim, S. Baek, S. Lee, J. Lee, S. Marbumrung, P. Kankaew, K. Chaorenpornpukdee, T. Chaipet, K. Shearman, A. Gören, S. Gündüz, H. Yilmaz, I. Un, G. Bilsel, C. Clarkson, M. Bedner, J. Camara, B. Lang, K. Lippa, M. Nelson, B. Toman, L. Yu
Dokumenttyp:Zeitschriftenartikel
Veröffentlichungsform:Verlagsliteratur
Sprache:Englisch
Titel des übergeordneten Werkes (Englisch):Metrologia
Jahr der Erstveröffentlichung:2018
Organisationseinheit der BAM:1 Analytische Chemie; Referenzmaterialien
1 Analytische Chemie; Referenzmaterialien / 1.3 Strukturanalytik
1 Analytische Chemie; Referenzmaterialien / 1.7 Organische Spuren- und Lebensmittelanalytik
1 Analytische Chemie; Referenzmaterialien / 1.8 Umweltanalytik
Verlag:Institute of Physics Publishing (IOP) ; Bureau International des Poids et Mesures
Jahrgang/Band:55
Ausgabe/Heft:Technical Supplement, 2018
Erste Seite:08013, 1
Letzte Seite:38
DDC-Klassifikation:Naturwissenschaften und Mathematik / Chemie / Analytische Chemie
Freie Schlagwörter:CCQM key comparison; Folic acid; Purity assessment
Themenfelder/Aktivitätsfelder der BAM:Analytical Sciences
Analytical Sciences / Spurenanalytik und chemische Zusammensetzung
DOI:https://doi.org/10.1088/0026-1394/55/1A/08013
URL:https://www.bipm.org/utils/common/pdf/final_reports/QM/K55/CCQM-K55.d.pdf
URL:http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS_CPL&DestLinkType=FullRecord&UT=WOS:000464690800047
Verfügbarkeit des Dokuments:Datei im Netzwerk der BAM verfügbar ("Closed Access")
Datum der Freischaltung:24.05.2018
Referierte Publikation:Ja
Datum der Eintragung als referierte Publikation:06.05.2019