L. Xin, M. Bungartz, S. Maenz, V. Horbert, M. Hennig, Bernhard Illerhaus, Jens Günster, J. Bossert, S. Bischoff, J. Borowski, H. Schubert, K. Jandt, E. Kunisch, R. Kinne, O. Brinkmann
- Vertebroplasty or kyphoplasty of osteoporotic vertebral fractures bears the risk of pulmonary cement embolism (3.5%–23%) caused by leakage of commonly applied acrylic polymethylmethacrylate (PMMA) cement to spongious bone marrow or outside of the vertebrae. Ultraviscous cement and specific augmentation systems have been developed to reduce such adverse effects. Rapidly setting, resorbable, physiological calcium phosphate cement (CPC) may also represent a suitable alternative.
PURPOSE: This study aimed to compare the intravertebral extrusion of CPC and PMMA cement in an ex vivo and in vivo study in sheep.
STUDY DESIGN/SETTING: A prospective experimental animal study was carried out. METHODS: Defects (diameter 5 mm; 15 mm depth) were created by a ventrolateral percutane-ous approach in lumbar vertebrae of female Merino sheep (2–4 years) either ex vivo (n = 17) or in vivo (n = 6), and injected with: (1) CPC (L3); (2) CPC reinforced with 10% poly(l-lactide-co-glycolide) (PLGA) fibers (L4);Vertebroplasty or kyphoplasty of osteoporotic vertebral fractures bears the risk of pulmonary cement embolism (3.5%–23%) caused by leakage of commonly applied acrylic polymethylmethacrylate (PMMA) cement to spongious bone marrow or outside of the vertebrae. Ultraviscous cement and specific augmentation systems have been developed to reduce such adverse effects. Rapidly setting, resorbable, physiological calcium phosphate cement (CPC) may also represent a suitable alternative.
PURPOSE: This study aimed to compare the intravertebral extrusion of CPC and PMMA cement in an ex vivo and in vivo study in sheep.
STUDY DESIGN/SETTING: A prospective experimental animal study was carried out. METHODS: Defects (diameter 5 mm; 15 mm depth) were created by a ventrolateral percutane-ous approach in lumbar vertebrae of female Merino sheep (2–4 years) either ex vivo (n = 17) or in vivo (n = 6), and injected with: (1) CPC (L3); (2) CPC reinforced with 10% poly(l-lactide-co-glycolide) (PLGA) fibers (L4); or (3) PMMA cement (L5; Kyphon HV-R). Controls were untouched (L1) or empty defects (L2). The effects of the cement injections were assessed in vivo by blood gas analysis and ex vivo by computed tomography (CT), micro-CT (voxel size: 67 µm), histology, and biomechanical testing.…
MetadatenAutor*innen: | L. Xin, M. Bungartz, S. Maenz, V. Horbert, M. Hennig, Bernhard Illerhaus, Jens GünsterORCiD, J. Bossert, S. Bischoff, J. Borowski, H. Schubert, K. Jandt, E. Kunisch, R. Kinne, O. Brinkmann |
---|
Dokumenttyp: | Zeitschriftenartikel |
---|
Veröffentlichungsform: | Verlagsliteratur |
---|
Sprache: | Englisch |
---|
Titel des übergeordneten Werkes (Englisch): | The Spine Journal |
---|
Jahr der Erstveröffentlichung: | 2016 |
---|
Verlag: | Elsevier Inc. |
---|
Jahrgang/Band: | 16 |
---|
Ausgabe/Heft: | 12 |
---|
Erste Seite: | 1468 |
---|
Letzte Seite: | 1477 |
---|
DDC-Klassifikation: | Technik, Medizin, angewandte Wissenschaften / Ingenieurwissenschaften / Ingenieurwissenschaften und zugeordnete Tätigkeiten |
---|
Freie Schlagwörter: | Bone marrow extrusion; Brushite-forming calcium phosphate cement; Cement injection; Ex vivo; High- viscosity PMMA cement; In vivo; Large animal model; Sheep; Vertebroplasty |
---|
DOI: | 10.1016/j.spinee.2016.07.529 |
---|
ISSN: | 1529-9430 |
---|
ISSN: | 1878-1632 |
---|
Verfügbarkeit des Dokuments: | Datei im Netzwerk der BAM verfügbar ("Closed Access") |
---|
Datum der Freischaltung: | 03.01.2017 |
---|
Referierte Publikation: | Ja |
---|
Datum der Eintragung als referierte Publikation: | 07.04.2017 |
---|