• Treffer 2 von 0
Zurück zur Trefferliste

Accelerating chemical process development and manufacturing – Design and validation of an integrated NMR micro mixer

  • The future competitiveness of the process industry and their providers depends on its ability to deliver high quality and high value products at competitive prices in a sustainable fashion, and to adapt quickly to changing customer needs. The transition of process industry due to the mounting digitalization of technical devices and their provided data used in chemical plants proceeds. Though, the detailed characteristics and consequences for the whole chemical and pharmaceutical industry are still unforeseeable, new potentials arise as well as questions regarding the implementation. As the digitalization gains pace fundamental subjects like the standardization of device interfaces or organization of automation systems must be answered. Still, process industry lack of sufficient system and development concepts with commercial advantage from this trend. Intensified continuous processes are in focus of current research. Compared to traditional batch processes, intensified continuousThe future competitiveness of the process industry and their providers depends on its ability to deliver high quality and high value products at competitive prices in a sustainable fashion, and to adapt quickly to changing customer needs. The transition of process industry due to the mounting digitalization of technical devices and their provided data used in chemical plants proceeds. Though, the detailed characteristics and consequences for the whole chemical and pharmaceutical industry are still unforeseeable, new potentials arise as well as questions regarding the implementation. As the digitalization gains pace fundamental subjects like the standardization of device interfaces or organization of automation systems must be answered. Still, process industry lack of sufficient system and development concepts with commercial advantage from this trend. Intensified continuous processes are in focus of current research. Compared to traditional batch processes, intensified continuous production allows new and difficult to produce compounds with better product uniformity and reduced consumption of raw materials and energy. Flexible (modular) chemical plants can produce various products using the same equipment with short down-times between campaigns, and quick introduction of new products to the market. Full automation is a prerequisite to realize such benefits of intensified continuous plants. In continuous flow processes, continuous, automated measurements and closed-loop control of the product quality are required. Consequently, the demand for smart sensors, which can monitor key variables like component concentrations in real-time, is increasing. Low-Field NMR spectroscopy presents itself as such an upcoming smart sensor (as addressed, e.g., in the CONSENS project – http://www.consens-spire.eu/). Systems utilizing such an online NMR analyzer benefits through short development and set-up times when applied to modular production plants starting from a desired chemical reaction. As an example for such a modular process unit, we present the design and validation of an integrated NMR micro mixer based on computational modelling suited for a desired chemical reaction. This method includes a proper design of a continuous reactor, which is optimized through computational fluid dynamics (CFD) for the demands of the NMR sensor as well as for the given reaction conditions. The system was validated with a chemical reaction process.zeige mehrzeige weniger

Volltext Dateien herunterladen

  • 2018-11-12_PAAT_JT_Bornemann_print.pdf
    eng

Metadaten exportieren

Weitere Dienste

Teilen auf Twitter Suche bei Google Scholar Anzahl der Zugriffe auf dieses Dokument
Metadaten
Autor*innen:Martin Bornemann-PfeifferORCiD
Koautor*innen:Simon Kern, N. Jurtz, M. Kraume, Michael Maiwald
Dokumenttyp:Vortrag
Veröffentlichungsform:Präsentation
Sprache:Englisch
Jahr der Erstveröffentlichung:2018
Organisationseinheit der BAM:1 Analytische Chemie; Referenzmaterialien
1 Analytische Chemie; Referenzmaterialien / 1.4 Prozessanalytik
DDC-Klassifikation:Naturwissenschaften und Mathematik / Chemie / Analytische Chemie
Freie Schlagwörter:Digital twin; Flow chemistry; NMR; Process analytical technology; Reaction monitoring
Themenfelder/Aktivitätsfelder der BAM:Umwelt
Umwelt / Sensorik
Veranstaltung:ProcessNet PAAT Jahrestreffen
Veranstaltungsort:Cologne, Germany
Beginndatum der Veranstaltung:12.11.2018
Enddatum der Veranstaltung:13.11.2018
Bemerkung:
Geburtsname von Bornemann-Pfeiffer, Martin: Bornemann, M. -  Birth name of Bornemann-Pfeiffer, Martin: Bornemann, M.
Verfügbarkeit des Dokuments:Datei im Netzwerk der BAM verfügbar ("Closed Access")
Datum der Freischaltung:15.11.2018
Referierte Publikation:Nein
Eingeladener Vortrag:Nein
Einverstanden
Diese Webseite verwendet technisch erforderliche Session-Cookies. Durch die weitere Nutzung der Webseite stimmen Sie diesem zu. Unsere Datenschutzerklärung finden Sie hier.