Test-strip-based fluorometric detection of fluoride in aqueous media with a BODIPY-linked hydrogen-bonding receptor
- The measurement of biologically relevant anions, such as fluoride, is an important task in analytical chemistry, in particular, for dental health and osteoporosis. Although a large number of fluoride probes are known, the applicability under relevant conditions is limited to a few examples. To improve this situation, BODIPY-amidothiourea dyes with varying hydrogen-bond donating strengths were developed, the most H-acidic of which (1 c) could detect F- from an inorganic source (NaF) in 50?% aqueous solution (DMSO/water 1:1, v/v) with 0.01 ppm sensitivity through selective fluorescence quenching by a photoinduced electron-transfer (PET) process. Use of the probe and a reference dye with a test-strip assay and a portable and rapidly recording lateral-flow fluorescence reader made determination of F- in neat aqueous solutions, such as spiked water samples and toothpaste extracts, possible in a self-referenced manner, achieving a detection limit of 0.2 ppm.
Autor*innen: | Pichandi Ashokkumar, Hardy Weißhoff, Werner Kraus, Knut RurackORCiD |
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Dokumenttyp: | Zeitschriftenartikel |
Veröffentlichungsform: | Verlagsliteratur |
Sprache: | Englisch |
Titel des übergeordneten Werkes (Englisch): | Angewandte Chemie / International Edition |
Jahr der Erstveröffentlichung: | 2014 |
Herausgeber (Institution): | Gesellschaft Deutscher Chemiker |
Verlag: | Wiley-VCH |
Verlagsort: | Weinheim |
Jahrgang/Band: | 53 |
Ausgabe/Heft: | 8 |
Erste Seite: | 2225 |
Letzte Seite: | 2229 |
Freie Schlagwörter: | Amidothiourea; Fluorescent probes; Fluoride; Hydrogen bonds; Photoinduced electron transfer |
DOI: | 10.1002/anie.201307848 |
ISSN: | 1433-7851 |
ISSN: | 1521-3773 |
ISSN: | 0570-0833 |
Verfügbarkeit des Dokuments: | Datei im Netzwerk der BAM verfügbar ("Closed Access") |
Datum der Freischaltung: | 20.02.2016 |
Referierte Publikation: | Ja |
Datum der Eintragung als referierte Publikation: | 13.11.2014 |