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Hierarchical organization of purely peptidic amphiphiles into peptide beads

  • A broad range of new properties is emerging from supramolecular aggregates as they pass beyond the limitations of simple molecules. Self-assembled structures of purely peptidic amphiphiles may exploit such properties to produce biocompatible, smart materials for drug administration. In aqueous media, the solid-phase derived amphiphilic undecapeptide described herein (Ac-X3-gT) forms self-assembled particles of spherical shape with diameters between 200 and 1500 nm, termed 'peptide beads'. The beads result from hierarchical organization of micellar-like structures, a fact determined by a combination of investigations carried out by electron and atomic force microscopy (AFM), static and dynamic light scattering, and small-angle X-ray scattering. These highly ordered structures agree with the concept of multicompartmentization and represent the first example of supramicellar assemblies based purely on peptides. New structural insights, as presented here, allow a better understanding ofA broad range of new properties is emerging from supramolecular aggregates as they pass beyond the limitations of simple molecules. Self-assembled structures of purely peptidic amphiphiles may exploit such properties to produce biocompatible, smart materials for drug administration. In aqueous media, the solid-phase derived amphiphilic undecapeptide described herein (Ac-X3-gT) forms self-assembled particles of spherical shape with diameters between 200 and 1500 nm, termed 'peptide beads'. The beads result from hierarchical organization of micellar-like structures, a fact determined by a combination of investigations carried out by electron and atomic force microscopy (AFM), static and dynamic light scattering, and small-angle X-ray scattering. These highly ordered structures agree with the concept of multicompartmentization and represent the first example of supramicellar assemblies based purely on peptides. New structural insights, as presented here, allow a better understanding of the beads' capacity to embed hydrophobic and hydrophilic payloads and therefore provide new perspectives for drug delivery applications that may result from this new class of material.zeige mehrzeige weniger

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Metadaten
Autor*innen:D. De Bruyn Ouboter, T.B. Schuster, Alexandre Mantion, W. Meier
Dokumenttyp:Zeitschriftenartikel
Veröffentlichungsform:Verlagsliteratur
Sprache:Englisch
Titel des übergeordneten Werkes (Englisch):The journal of physical chemistry / C
Jahr der Erstveröffentlichung:2011
Herausgeber (Institution):American Chemical Society
Verlag:Soc.
Verlagsort:Washington, DC
Jahrgang/Band:115
Ausgabe/Heft:30
Erste Seite:14583
Letzte Seite:14590
Freie Schlagwörter:Hierarchical self-assembly; Multicompartment micelles; Peptide beads; Purely peptidic amphiphiles; Spherical peptide particles
DOI:10.1021/jp203048h
ISSN:1932-7447
ISSN:1089-5639
Verfügbarkeit des Dokuments:Datei im Netzwerk der BAM verfügbar ("Closed Access")
Datum der Freischaltung:19.02.2016
Referierte Publikation:Ja
Datum der Eintragung als referierte Publikation:05.09.2011
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