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First steps towards field integration of benchtop NMR spectroscopy for online monitoring and process control

  • Online monitoring and process control requires fast and noninvasive analytical methods, which are able to monitor the concentration of reactants in multicomponent mixtures with parts-per-million resolution. Online NMR spectroscopy can meet these demands when flow probes are directly coupled to reactors, since this method features a high linearity between absolute signal area and sample concentration, which makes it an absolute analytical comparison method being independent on the matrix. Due to improved magnet design and field shimming strategies portable and robust instruments have been introduced to the market by several manufacturers during the last few years. First studies with this technology showed promising results to monitor chemical reaction in the laboratory. Within the project CONSENS, the continuous production of high-value products in small production scale is advanced by introducing MR-NMR spectroscopy. CONSENS is a research and innovation project on integratedOnline monitoring and process control requires fast and noninvasive analytical methods, which are able to monitor the concentration of reactants in multicomponent mixtures with parts-per-million resolution. Online NMR spectroscopy can meet these demands when flow probes are directly coupled to reactors, since this method features a high linearity between absolute signal area and sample concentration, which makes it an absolute analytical comparison method being independent on the matrix. Due to improved magnet design and field shimming strategies portable and robust instruments have been introduced to the market by several manufacturers during the last few years. First studies with this technology showed promising results to monitor chemical reaction in the laboratory. Within the project CONSENS, the continuous production of high-value products in small production scale is advanced by introducing MR-NMR spectroscopy. CONSENS is a research and innovation project on integrated control and sensing for sustainable operation of flexible intensified processes. This poster will present the first steps of the process integration of a benchtop NMR instrument for a lithiation process and outlines further fields of activity and potential challenges. Hereby, the following issues are going to be addressed: explosion-proof housing for the spectrometer, automation of signal processing (data pretreatment, evaluation and communication to the control system), flow cells and measuring conditions. Additionally, the first results of the lithiation reaction in lab scale regarding the pure components and reaction mixtures are going to be discussed.zeige mehrzeige weniger

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Metadaten
Autoren/innen:Simon Kern
Koautoren/innen:Nicolai Zientek, Michael Maiwald
Dokumenttyp:Posterpräsentation
Veröffentlichungsform:Präsentation
Sprache:Englisch
Titel des übergeordneten Werkes (Englisch):Small Molecule NMR Conference
Jahr der Erstveröffentlichung:2015
Organisationseinheit der BAM:1 Analytische Chemie; Referenzmaterialien
1 Analytische Chemie; Referenzmaterialien / 1.4 Prozessanalytik
Veröffentlichende Institution:Bundesanstalt für Materialforschung und -prüfung (BAM)
Veranstaltung:Small Molecule NMR Conference
Veranstaltungsort:Baveno, Italy
Beginndatum der Veranstaltung:17.09.2015
Enddatum der Veranstaltung:22.09.2015
URN:urn:nbn:de:kobv:b43-351085
Verfügbarkeit des Volltexts:Volltext-PDF für die Öffentlichkeit verfügbar ("Open Access")
Datum der Freischaltung:20.02.2016
Referierte Publikation:Nein
Schriftenreihen ohne Nummerierung:BAM Präsentationen