TY - CONF A1 - Nguyen, Thi Yen A1 - Bernardes, C. E. S. A1 - Minas da Piedade, M. E. A1 - Rademann, K. A1 - Emmerling, Franziska T1 - Guided crystallization: The influence of solvent and concentration N2 - Theoretical and experimental studies indicate that crystal nucleation can take more complex pathways than expected on the ground of the classical nucleation theory. A direct in situ observation of the different pathways of nucleation from solution is challenging since the paths can be influenced by heterogeneous nucleation sites, such as container walls. The custom-made acoustic levitator using in these experiments regulates the influence that solid surfaces, temperature, and humidity have on the crystallization process. The investigations of the crystallization process of paracetamol were performed with in situ analytical techniques and theoretical simulations to gain a comprehensive insight into processes, occurring intermediates, and required reaction conditions. The targeted choice of the solvent and the concentration enabled the guidance of the pathways, therefore, resulting in the isolation of one desired crystalline structure. T2 - Annual COST meeting CY - Lincoln, United Kingdom DA - 25.06.2017 KW - Crystallization KW - Polymorphism KW - Molecular dynamic simulation KW - Pair distribution function analysis KW - XRD PY - 2017 AN - OPUS4-41111 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -