TY - CONF A1 - Bertin, Annabelle A1 - Asadujjaman, Asad A1 - Ahmadi, Vahid A1 - Schönhals, Andreas A1 - ten Brummelhuis, N. T1 - Upper critical solution temperature (UCST)-type thermoresponsive polymers from hydrogen-bonding monomers N2 - UCST-type thermoresponsive polymers (i.e. that phase separate from solution upon cooling) present a tremendous potential not only in aqueous media where they can be used in drug delivery, diagnostic and microfluidic applications, but also in water/alcohol mixtures, where they can be used for instance in sensing systems for alcohol-soluble drugs. However, only a few thermoresponsive polymers have been reported that present an UCST in a relevant temperature range and “green” solvents such as water or ethanol. In this context, acrylamide-based monomers can be very useful building blocks for designing novel non-ionic UCST-type polymers because of their hydrophilic nature (with the appropriate side chain) and propensity to form hydrogen bonds. We will present our latest results on the UCST-type thermoresponsive behaviour of acrylamide- and 2,6-diaminopyridine-based homopolymers and copolymers in water or water/alcohol mixtures, and give some insights about the rational design of UCST polymers relying on H-bonding. T2 - UCT&IOCB Theoretical Chemistry Seminars CY - University of Chemistry and Technology, Department of Physical Chemistry, Prague, Czech Republic DA - 24.11.2017 KW - Thermoresponsive polymers KW - UCST polymers KW - 2,6-diaminopyridine PY - 2017 AN - OPUS4-43129 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Bertin, Annabelle A1 - Czarnecki, Sebastian A1 - Hackelbusch, Sebastian T1 - Bioinspired hybrid organic-inorganic copolymers N2 - The demand for high-performance materials has strongly increased over the last decade. One way to improve their performance is to introduce material gradients as found in Nature (for example squid beaks, spider fangs, mussel byssal threads). One path towards the achievement of such material gradients is the synthesis of hybrid (gradient) copolymers, for instance based on silane and organic monomers. Since not all gradient copolymers can be synthesized by utilising the reactivity ratios of the monomers, forced gradients have to be used. However, in order to obtain gradient copolymers at high conversions, living or pseudo-living copolymerizations have to be performed and so far only few hybrid (organic / inorganic) gradient copolymers have been reported. In this contribution we will present the synthesis of a novel organic / inorganic hybrid copolymer via controlled radical polymerization. T2 - 5th International Conference on Multifunctional, Hybrid and Nanomaterials CY - Lisbon, Portugal DA - 06.03.2017 KW - Hybrid organic-inorganic copolymers KW - RAFT polymerization KW - ATRP polymerization PY - 2017 AN - OPUS4-39464 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Bertin, Annabelle A1 - Schönhals, Andreas A1 - ten Brummelhuis, N. A1 - Ahmadi, Vahid A1 - Asadujjaman, Asad T1 - Upper critical solution temperature (UCST)-type thermoresponsive polymers from acrylamide-based monomers N2 - UCST-type thermoresponsive polymers (i.e. that phase separate from solution upon cooling) present a tremendous potential not only in aqueous media where they can be used in drug delivery, diagnostic and microfluidic applications but also in water/alcohol mixtures, where they can be used for instance in sensing systems for alcohol-soluble drugs. However, only a few thermoresponsive polymers have been reported that present an UCST in a relevant temperature range and “green” solvents such as water or ethanol. In this context, acrylamide-based monomers can be very useful building blocks for designing novel non-ionic UCST-type polymers because of their hydrophilic nature (with the right side chain) and propensity to form hydrogen bonds. We will present our latest results on the UCST-type thermoresponsive behaviour of acrylamide- and 2,6-diaminopyridine-based homopolymers and copolymers in water or water/alcohol mixtures, and give some insights about the rational design of UCST polymers relying on H-bonding. T2 - Bioorganik 2017 – 26th Symposium "Bioorganic Chemistry" for young researchers CY - Berlin, Germany DA - 20.09.2017 KW - Thermoresponsive polymers KW - UCST polymers KW - 2,6-diaminopyridine KW - Acrylamide PY - 2017 AN - OPUS4-42007 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Bertin, Annabelle A1 - Taabache, Soraya A1 - Maskos, M. T1 - Controlled Self-Assembly of Janus Dendrimers via Microfluidics N2 - Unilamellar vesicles self-assembled in water from natural and synthetic phospholipids (liposomes), amphiphilic block copolymers (polymersomes), and more recently amphiphilic Janus dendrimers (dendrimersomes) as hollow soft structures in the nano size regime have attracted increasing interest as they can mimic primitive and contemporary biological membranes, and can be configured into biomimetic nanocapsules with application in nanomedicine such as gene, proteins and drug carriers or theranostics. Compared to other amphiphilic structures, the molecular structure of Janus dendrimers can be precisely controlled: by using the vast range of tools from organic chemistry their size, architecture, density, generation as well as the number of endgroups of the individual dendrons can be modified as desired. Unfortunately, the controlled production of the supramolecular aggregates made thereof is still a challenging task. Conventional batch-based techniques such as the solvent injection method or the film hydration method typically go along with a lack of control over mixing and thus over size, morphology and size distribution. The micromixer technology is a promising method for the controlled preparation of supramolecular assemblies as it allows control of mixing at microscale level. In addition, such microfluidic systems benefit from a high mixing efficiency, a low mixing time as well as from a reproducible and continuous synthesis. Herein, we report on the microfluidic-controlled self-assembly of Janus dendrimers as dendrimersomes and the impact of the mixing parameters on the self-assembly process. T2 - 10th International Dendrimer Symposium CY - Weihai, China DA - 05.08.2017 KW - Micromixers KW - Janus dendrimers KW - Vesicles KW - Self-assembly PY - 2017 AN - OPUS4-41464 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Bertin, Annabelle A1 - Asadujjaman, Asad A1 - Ahmadi, Vahid T1 - Upper critical solution temperature (UCST)-type thermoresponsive polymers from hydrogen-bonding monomers N2 - UCST-type thermoresponsive polymers (i.e. that phase separate from solution upon cooling) present a tremendous potential not only in aqueous media where they can be used in drug delivery, diagnostic and microfluidic applications, but also in water/alcohol mixtures, where they can be used for instance in sensing systems for alcohol-soluble drugs. However, only a few thermoresponsive polymers have been reported that present an UCST in a relevant temperature range and “green” solvents such as water or ethanol. In this context, acrylamide-based monomers can be very useful building blocks for designing novel non-ionic UCST-type polymers because of their hydrophilic nature (with the appropriate side chain) and propensity to form hydrogen bonds. We will present our latest results on the UCST-type thermoresponsive behaviour of acrylamide- and 2,6-diaminopyridine-based homopolymers and copolymers in water or water/alcohol mixtures, and give some insights about the rational design of UCST polymers relying on H-bonding. T2 - Séminaire Laboratoire de Chimie des Polymères (LCP), UPMC, Paris CY - Paris, France DA - 28.09.2017 KW - UCST-type polymers KW - H-bonding monomers PY - 2017 AN - OPUS4-42478 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Bertin, Annabelle A1 - Taabache, Soraya A1 - Maskos, M. T1 - Controlled self-assembly of Janus dendrimers via microfluidics N2 - Vesicles self-assembled in water from natural and synthetic phospholipids (liposomes), amphiphilic block copolymers (polymersomes), and more recently amphiphilic Janus dendrimers (dendrimersomes) -5 as hollow soft structures in the nano size regime have attracted increasing interest as they can mimic primitive and contemporary biological membranes, and can be configured into biomimetic nanocapsules with application in nanomedicine such as gene, proteins and drug carriers or theranostics. Compared to other amphiphilic structures, the molecular structure of Janus dendrimers can be precisely controlled: by using the vast range of tools from organic chemistry their size, architecture, density, generation as well as the number of end groups of the individual dendrons can be modified as desired. Unfortunately, the controlled production of the supramolecular aggregates made thereof is still a challenging task. Conventional batch-based techniques such as the solvent injection method or the film hydration method typically go along with a lack of control over mixing and thus over size, morphology and size distribution. The micromixer technology is a promising method for the controlled preparation of supramolecular assemblies as it allows control of mixing at microscale level. In addition, such microfluidic systems benefit from a high mixing efficiency, a low mixing time as well as from a reproducible and continuous synthesis. Herein, we report on the microfluidic-controlled self-assembly of Janus dendrimers as dendrimersomes and the impact of the mixing parameters on the self-assembly process. T2 - 11th Young Scientists' Workshop, Fraunhofer ICT-IMM CY - Mainz, Germany DA - 27.09.2017 KW - Vesicles KW - Dendrimersomes KW - Micromixer PY - 2017 AN - OPUS4-42479 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Bertin, Annabelle A1 - Taabache, Soraya A1 - Maskos, M. T1 - Controlled self-assembly of Janus dendrimers via microfluidics N2 - Vesicles self-assembled in water from natural and synthetic phospholipids (liposomes), amphiphilic block copolymers (polymersomes), and more recently amphiphilic Janus dendrimers (dendrimersomes) as hollow soft structures in the nano size regime have attracted increasing interest as they can mimic primitive and contemporary biological membranes, and can be configured into biomimetic nanocapsules with application in nanomedicine such as gene, proteins and drug carriers or theranostics. Compared to other amphiphilic structures, the molecular structure of Janus dendrimers can be precisely controlled: by using the vast range of tools from organic chemistry their size, architecture, density, generation as well as the number of end groups of the individual dendrons can be modified as desired. Unfortunately, the controlled production of the supramolecular aggregates made thereof is still a challenging task. Conventional batch-based techniques such as the solvent injection method or the film hydration method typically go along with a lack of control over mixing and thus over size, morphology and size distribution. The micromixer technology is a promising method for the controlled preparation of supramolecular assemblies as it allows control of mixing at microscale level. In addition, such microfluidic systems benefit from a high mixing efficiency, a low mixing time as well as from a reproducible and continuous synthesis. Herein, we report on the microfluidic-controlled self-assembly of Janus dendrimers as dendrimersomes and the impact of the mixing parameters on the self-assembly process. T2 - 6th Annual workshop on biomaterials and their interactions with biological and model membranes 2017 CY - Altafulla, Spain DA - 07.09.2017 KW - Janus dendrimers KW - Dendrimersomes KW - Microfluidic PY - 2017 AN - OPUS4-41903 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Bertin, Annabelle A1 - Asadujjaman, Asad A1 - Ahmadi, Vahid A1 - Yalcin, M. A1 - ten Brummelhuis, N. T1 - Functional Thermoresponsive Polymers based on 2,6-Diaminopyridine with Tunable UCST Behavior N2 - Thermoresponsive polymers are of great importance in numerous applications such as bioseparation, drug delivery, diagnostic and microfluidic applications. Only few thermoresponsive polymers that present an upper critical solution temperature (UCST), i.e. phase separate from solution upon cooling, in a relevant temperature range and green solvents such as water or ethanol have been reported. In this work two novel functional polymers of based on a 2,6-diaminopyridine motif, namely poly(N-(6-aminopyridin-2-yl)acrylamide) (PNAPAAm) and poly(N-(6-acetamidopyridin-2-yl)acrylamide) (PNAcAPAAm), were synthesized by free radical polymerization. The obtained polymers displayed UCST-type reversible thermoresponsive behaviour in water/alcohol mixtures. Insights into this phenomenon will be given based on visual observations, temperature-dependent turbidimetry and dynamic light scattering as well as 1H-NMR measurements. The UCST phase transition behaviour of the polymers was tunable by varying either the concentration of the polymer solution, the nature of the alcohol or the composition of the solvent mixture. The cloud point temperature of PNAcAPAAm was found to decrease with increasing alcohol content (MeOH, EtOH and iPrOH) in water/alcohol mixtures. Past a critical amount of EtOH or iPrOH in water the cloud point temperature of PNAcAPAAm increased by further addition of EtOH or iPrOH. These polymers with UCST behavior below 60°C in water/alcohol mixtures show great promises for the preparation of smart materials for sensing. T2 - European Polymer Congress Lyon 2017 CY - Lyon, France DA - 02.07.2017 KW - Cosolvency KW - UCST polymer KW - 2,6-diaminopyridine PY - 2017 AN - OPUS4-40965 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -