TY - CONF A1 - Resch-Genger, Ute T1 - Approaches to the Determination of the Spectral Characteristics of Confocal Spectral Imaging Systems and Comparability of Data T2 - ANAKON 2005 CY - Regensburg, Germany DA - 2005-03-15 PY - 2005 AN - OPUS4-7450 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Matthews, Lauren T1 - Approaches to Surface Analysis of Modified Quartz Nanopipettes N2 - Nanopipettes are a type of solid-state nanopore with needle-like geometry. Their applications range from imaging, sensing, diagnostics, and use as injectors. The response of nanopipette sensors is highly dependent on the size, geometry and chemical properties of the sensing region. As they are increasingly tuned and modified for specific analytes, a better understanding of the surface chemistry and morphology of the inner channel is necessary. With the aim of developing a comprehensive approach for characterisation of such nanopipettes, this research focuses on combining surface-sensitive analysis methods with advanced sample preparation techniques. Quartz substrates were modified by gas phase silanization, a well-utilised technique in the field to enhance performance of nanopipettes, and further functionalised with a metal bis thiolate complex, to aid in chemical analysis. The sample characterisation involved scanning electron microscopy (SEM), low-energy dispersive x-ray spectroscopy (EDX), time-of-flight secondary ion mass spectrometry (ToF-SIMS) and Auger electron spectroscopy (AES). Using focused ion beam (FIB) milling under gentle conditions, the inner surface of quartz nanopipettes was exposed whilst preserving the integrity of the overall structure (see figure). Owing to the challenging analysis conditions, modification and analysis of flat quartz substrates has been performed in parallel for optimisation purposes. The results demonstrate the first steps towards full characterisation of nanopipettes at the nanoscale, notably with access to the inner channel. The methods used here can be applied to gain further understanding of the response of these sensors to complex analytes and allow for the study of different surface functionalisations at the all-important sensing region. T2 - European Conference on Applications of Surface and Interface Analysis (ECASIA 2024) CY - Gothenburg, Sweden DA - 09.06.2024 KW - Quartz nanopipettes KW - Nanopipette modification KW - Silanization KW - Surface analysis KW - Focussed ion beam PY - 2024 AN - OPUS4-60447 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Matthews, Lauren T1 - Approaches to Surface Analysis of Modified Quartz Nanopipettes N2 - Nanopipettes are a type of solid-state nanopore with needle-like geometry. Their applications range from imaging, sensing, diagnostics, and use as injectors. The response of nanopipette sensors is highly dependent on the size, geometry and chemical properties of the sensing region. As nanopipettes are increasingly tuned and modified for specific analytes, a better understanding of the surface chemistry and morphology of the inner channel is necessary. For exploring these effects, quartz nanopipettes were modified by gas phase silanization, a well-utilised technique in the field to enhance performance of nanopipettes, and further functionalised with a metal bis thiolate complex, to aid in chemical analysis. The inner channel of the sensing region was exposed with focused ion beam (FIB) milling as a dedicated sample preparation method for nanoscale surface analysis. The sample characterisation involved scanning electron microscopy (SEM), Auger electron spectroscopy (AES) and low-energy energy dispersive x-ray spectroscopy (EDX). The results demonstrate the first steps towards full characterisation of nanopipettes at the nanoscale, notably with access to the inner channel. The methods used here can be applied to gain further understanding of the response of these sensors to complex analytes, and allow for the study of different surface functionalisation at the all-important sensing region. T2 - 2024 Spring Meeting of the European Materials Research Society (E-MRS) CY - Strasbourg, France DA - 27.05.2024 KW - Nanopipettes KW - FIB KW - Surface analysis KW - Surface modification KW - Silanisation PY - 2024 AN - OPUS4-60449 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Rurack, Knut T1 - Approaches to Sensitive and Multiplexed Assays for Robust, Reliable and User-friendly Point-of-Need Analysis N2 - Analytical assays that can be used outside of a dedicated laboratory environment have received unprecedented attention all around the globe during the last one and a half years, in which the world was struggling with and trying to contain the SARS-CoV-2 pandemic. However, besides their current prominence in the field of medical diagnostics, rapid tests and assays have also become increasingly important in other areas ranging from food and feed via security and forensics to environmental management. The advantage is obvious: taking the assay to the sample instead of bringing the sample to the laboratory minimizes the time between first suspicion and first decision taking. Especially today, where mobile communication devices with powerful computing capabilities and onboard cameras are omnipresent, the majority of the global population possesses the basic skills of operating a powerful detector, ready at their fingertips. The stage is thus set for a much broader use of analytical measurements in terms of prognostics and prevention. Today, however, tests for single parameters are still prevailing, whether it is a SARS-CoV-2 biomarker, the glucose level in blood or the concentration of lead in a water sample. Also, for industrial use, many mobile analytical systems still target a single parameter, and several separate runs or tests have to be used even if one wants to screen for only a small number of key parameters. Current challenges in the field thus lie with the development of low-number multiplexing strategies while allowing for robust, reliable, fast, and user-friendly operation and while still reaching the required sensitivities. This lecture will give an overview of various generic approaches developed in BAM’s Chemical and Optical Sensing Division over the years to address these challenges. In particular, it will highlight how the combination of supramolecular (bio)chemistry, luminescence detection, hybrid (nano)materials and device miniaturization can result in powerful (bio)analytical assays that can be used at a point-of-need. Selected examples will introduce key aspects of such systems like tailored signaling mechanisms and recognition elements, materials functionalization and device integration, including hybrid mesoporous nanomaterials, gated indicator release systems, molecularly imprinted polymers, microfluidic devices, test strips and smartphone-based analysis. T2 - Advanced Analytical Technologies Seminar CY - Online meeting DA - 08.12.2021 KW - Rapid tests KW - Multiplexing KW - Trace analysis PY - 2021 AN - OPUS4-54002 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Bremser, Wolfram A1 - Paul, Andrea T1 - Approaches to measurement uncertainty estimates for nominal properties N2 - Qualitative reference materials (RM) cover a wide range of the overall RM market. Proficiency testing providers attract up to a thousand of participants in PT schemes purely oriented on qualitative results. The RM used for these kinds of PT are poorly regulated, nevertheless with a more and more general acceptance of accreditation in the field of RM production and PT provision, there is an ever increasing interest in assessing producers and providers according to rules already well accepted in the field of quantitative analysis. The basic governing document, ISO 17034:2016, is written in a form that, at least for the overwhelming majority of requirements, may be applied to both qualitative and quantitative RM. However, problems remain. In particular, the expression of uncertainty of a purely qualitative result is still unresolved, and under discussion, the latter now lasting already dozens of years. Some handles would be needed. In the poster, existing approaches and some pragmatic, new ways to tackle the problem are displayed and discussed. T2 - Advanced Mathematical and Computational Tools for Metrology; AMCTM (XI) CY - Glasgow, Scotland, UK DA - 29 August 2017 KW - Nominal properties KW - Qualitative RM PY - 2017 AN - OPUS4-42467 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Resch-Genger, Ute T1 - Approaches to Lifetime Multiplexing with Quantum Dots and Organic Dyes: First Examples T2 - Kolloquium im Rahmen der FluoPlex-Treffen am Max-Planck-Institut für Molekulare Genetik CY - Berlin, Germany DA - 2008-06-17 PY - 2008 AN - OPUS4-18062 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Bremser, Wolfram T1 - Approaches to data evaluation for inter-laboratory studies T2 - ILS-BAM-DIBt Workshop CY - Berlin, Germany DA - 2008-04-09 PY - 2008 AN - OPUS4-18514 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Wille, Frank T1 - Approaches of Trunnion Design T2 - IAEA Working Group Meeting on Tie-Down System Design CY - IAEA Vienna, Austria DA - 2015-02-23 PY - 2015 AN - OPUS4-32791 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Meermann, Björn T1 - Approaches for PFAS Sum-Parameter Analysis -from Materials to Environment N2 - Im Rahmen des Vortags wurden PFAS Analysemethoden auf Basis der optischen Spektroskopie (HR-CS-GFMAS) vorgestellt. Anhand ausgewählter Applikationsbeispiele wurde die Leistungsfähigkeit der Methode dargelegt. Beispiele waren dabei u.a. aus dem Bereich Oberflächenwasseranalytik, Pflanzen und Böden. T2 - VD LUFA Kongress CY - Oldenburg, Germany DA - 09.09.2025 KW - HR-CS-GFMAS KW - PFAS KW - Summenparameter PY - 2025 AN - OPUS4-65127 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Meermann, Björn T1 - Approaches for PFAS Sum-Parameter Analysis - from Materials to Environment N2 - Im Rahmen des Vortags wurden PFAS Analysemethoden auf Basis der optischen Spektroskopie (HR-CS-GFMAS) vorgestellt. Anhand ausgewählter Applikationsbeispiele wurde die Leistungsfähigkeit der Methode dargelegt. Beispiele waren dabei u.a. aus dem Bereich Oberflächenwasseranalytik, Pflanzen und Böden. T2 - Industrie Anwenderseminar PFAS 2025 CY - Online meeting DA - 30.06.2025 KW - PFAS KW - HR-CS-GFMAS KW - Summenparameter PY - 2025 AN - OPUS4-65125 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -