TY - JOUR A1 - Kader, A. A1 - Brangsch, J. A1 - Kaufmann, Jan Ole A1 - Zhao, J. A1 - Mangarova, D. B. A1 - Moeckel, J. A1 - Adams, L. C. A1 - Sack, I. A1 - Taupitz, M. A1 - Hamm, B. A1 - Makowski, M. R. T1 - Molecular MR Imaging of Prostate Cancer N2 - This review summarizes recent developments regarding molecular imaging markers for magnetic resonance imaging (MRI) of prostate cancer (PCa). Currently, the clinical standard includes MR imaging using unspecific gadolinium-based contrast agents. Specific molecular probes for the diagnosis of PCa could improve the molecular characterization of the tumor in a non-invasive examination. Furthermore, molecular probes could enable targeted therapies to suppress tumor growth or reduce the tumor size. KW - Prostate cancer KW - Magnetic resonance imaging KW - Molecular imaging KW - Imaging KW - Molecular marker KW - Screening KW - MRI KW - Diagnosis PY - 2021 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-519503 DO - https://doi.org/10.3390/biomedicines9010001 VL - 9 IS - 1 SP - 1 EP - 17 PB - MDPI CY - Basel AN - OPUS4-51950 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Kuner, Maximilian T1 - Cleaving ergot alkaloids - development of a novel food screening method N2 - Mycotoxins (toxic compounds formed by fungi) in food and feed have caused problems for mankind since the beginning of time. The group of ergot alkaloids plays a special role in human history. Several tens of thousands of deaths during the middle ages caused by to ergotism (the disease caused by continuous intake of ergot alkaloid contaminated food) underscore the importance of reliable analytical methods to ensure food safety. More than 50 compounds belong to the group of ergot alkaloids. The 12 most found structures – the major ergot alkaloids – are typically measured, when it comes to ergot alkaloid quantification. High performance liquid chromatography (HPLC) with a fluorescence detector (FLD) is typically used to quantify the ergot alkaloid content. The main disadvantage of this method are the high costs for calibration standards (12 different calibration substances are required). But also, the time and effort required for the analysis of 12 peaks and overlapping signals that occur in complex food samples such as bread. As all ergot alkaloids share the ergoline structure and just differ in the substituents attached to this backbone, measurement of all ergot alkaloids in one sum parameter presents a time and cost saving alternative. The most important step for the development of such a sum parameter method is the reaction used to transfer all ergot alkaloids to one uniform structure. Two promising reactions, the acidic esterification to lysergic acid methyl ester and hydrazinolysis to lysergic acid hydrazide, were examined for possible use in a routine analysis method. In addition to yield and reaction rate, factors such as handling of the reaction and the possibility of parallel sample workup play a role. T2 - Adlershofer Forschungsforum 2022 CY - Berlin, Germany DA - 11.11.2022 KW - Ergot alkaloids KW - Screening PY - 2022 AN - OPUS4-56585 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Tavernaro, Isabella T1 - Multivalent presentation of phenylpropenic acid amide inspired ligands by various nanoparticles and their potential use in anti-inflammatory therapy N2 - Over the years, inflammation has become one of the most rapidly developing areas in medical research, due to new studies indicating its important role in chronical diseases, thrombosis and cancer. A promising target for anti-inflammatory therapy are the multistep adhesion process of leukocytes from the blood vessels into the inflamed tissue. and the numerous involved receptors and ligands. In particular, selectins and their respective carbohydrate ligands can inhibit this key step of the inflammation cascade. In previous work, it was shown that the multivalent presentation of highly negatively charged sulfated and carboxylated ligands on the particle surface can mimic natural selectin binders and increase the inhibition significantly. Recent studies of the antioxidant and health promoting properties of cocoa, dark chocolate and red clover indicating potential anti-inflammatory properties of their clovamide-type phenylpropenoic acid amides, which are able to inhibit p-selectin expression and platelet-leukocyte interactions. Following the idea of small-molecule targeting drugs, we selected different epitopes and immobilized their sulfated derivatives onto different types nanoparticles, followed by a screening of their performance. T2 - SALSA Make and Measure 2024: Interfaces CY - Berlin, Germany DA - 11.09.2024 KW - Gold colloids KW - Surface group analysis KW - Method KW - Quantification KW - Screening KW - Nano KW - Particle KW - Synthesis KW - Quality assurance KW - Surface ligands PY - 2024 AN - OPUS4-62159 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -