TY - JOUR A1 - Wegner, Karl David A1 - Häusler, I. A1 - Knigge, Xenia A1 - Hodoroaba, Vasile-Dan A1 - Emmerling, Franziska A1 - Reiss, P. A1 - Resch-Genger, Ute T1 - One-Pot Heat-Up Synthesis of ZnSe Magic-Sized Clusters Using Thiol Ligands N2 - The synthesis of two new families of ZnSe magic-sized clusters (MSCs) is achieved using the thiol ligand 1-dodecanethiol in a simple one-pot heat-up approach. The sizes of the MSCs are controlled with the thiol ligand concentration and reaction temperature. KW - ZnSe KW - Magic-sized cluster KW - Dodecanethiol KW - Semiconductor nanocrystals KW - One-pot synthesis PY - 2022 DO - https://doi.org/10.1021/acs.inorgchem.2c00041 VL - 61 IS - 19 SP - 7207 EP - 7211 PB - ACS Publications CY - Washington, DC (USA) AN - OPUS4-54880 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Gugin, Nikita A1 - Schwab, Alexander A1 - Carraro, Francesco A1 - Tavernaro, Isabella A1 - Falkenhagen, Jana A1 - Villajos, Jose A1 - Falcaro, Paolo A1 - Emmerling, Franziska T1 - ZIF-8-based biocomposites via reactive extrusion: towards industrial-scale manufacturing N2 - Mechanochemistry, a sustainable synthetic method that minimizes solvent use, has shown great promise in producing metal–organic framework (MOF)-based biocomposites through ball milling. While ball milling offers fast reaction times, biocompatible conditions, and access to previously unattainable biocomposites, it is a batch-type process typically limited to gram-scale production, which is insufficient to meet commercial capacity. We introduce a scalable approach for the continuous solid-state production of MOF-based biocomposites. Our study commences with model batch reactions to examine the encapsulation of various biomolecules into Zeolitic Imidazolate Framework-8 (ZIF-8) via hand mixing, establishing a foundation for upscaling. Subsequently, the process is scaled up using reactive extrusion, enabling continuous and reproducible kilogram-scale production of bovine serum albumin (BSA)@ZIF-8 with tunable protein loading. Furthermore, we achieve the one-step formation of shaped ZIF-8 extrudates encapsulating clinical therapeutic hyaluronic acid (HA). Upon release of HA from the composite, the molecular weight of HA is preserved, highlighting the industrial potential of reactive extrusion for the cost-effective and reliable manufacturing of biocomposites for drug-delivery applications. KW - Mechanochemistry KW - Extrusion KW - Biocompoites KW - MOFs PY - 2026 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-654777 DO - https://doi.org/10.1039/D5TA08276E SN - 2050-7496 SP - 1 EP - 14 PB - Royal Society of Chemistry AN - OPUS4-65477 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -