TY - JOUR A1 - Podshivalov, L. A1 - Wirth, Cynthia A1 - Zocca, Andrea A1 - Günster, Jens A1 - Bar-Yoseph, P. A1 - Fischer, A. T1 - Design, analysis and additive manufacturing of porous structures for biocompatible micro-scale scaffolds N2 - Advancements in the fields of biocompatible materials, manufacturing processes, computational methods and medicine have led to the emergence of a new field: micro-scale scaffolds for bone replacement and regeneration. Yet most such scaffolds produced today are characterized by very basic geometry, and their microstructure differs greatly from that of the actual tissue they are intended to replace. In this paper, we propose a novel approach for generating micro-scale scaffolds based on processing actual micro-CT images and then reconstructing a highly accurate geometrical model. This model is manufactured by means of a state-of-the-art 3D additive manufacturing process from biocompatible materials. At the micro-scale level, these scaffolds are very similar to the original tissue, thus interfacing better with the surrounding tissue and facilitating more efficient rehabilitation for the patient. Moreover, the approach facilitates the design and manufacture of patient-specific scaffolds which can copy patients’ exact structural and mechanical characteristics, taking into account their physical condition and medical history. By means of multi-resolution volumetric modeling methods, scaffold porosity can also be adapted according to specific mechanical requirements. The process of designing and manufacturing micro-scale scaffolds involves five major stages: (a) building a volumetric multi-resolution model from micro-CT images; (b) generation of surface geometric model in STL format; (c) additive manufacturing of the scaffold; (d) scaffold shape verification relative to the geometric design; and (e) verification of mechanical properties through finite element analysis. In this research, all the proposed stages of the approach were tested. The input included micro-CT scans of porous ceramic structure, which is quite similar to commercial porous scaffolds. The results show that the proposed method is feasible for design and manufacture of micro-scale scaffolds. KW - Micro-scale bone scaffolds KW - Additive manufacturing KW - Multiscale FEA KW - Ceramics KW - Multiresolution modeling PY - 2013 DO - https://doi.org/10.1016/j.procir.2013.01.049 SN - 2212-8271 N1 - Geburtsname von Wirth, Cynthia: Gomes, C. M. - Birth name of Wirth, Cynthia: Gomes, C. M. VL - 5 SP - 247 EP - 252 PB - Elsevier CY - Amsterdam [u.a.] AN - OPUS4-28003 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Elsayed, H. A1 - Zocca, Andrea A1 - Bernardo, E. A1 - Wirth, Cynthia A1 - Günster, Jens A1 - Colombo, P. T1 - Development of bioactive silicate-based glass-ceramics from preceramic polymer and filler N2 - 2014AbstractWollastonite/apatite glass-ceramics have been successfully prepared by a novel approach, consisting of the heat treatment of a silicone resinembedding micro-sized CaCO3particles, that act as reactive fillers, and bioactive glass powder in the SiO2–CaO–P2O5–K2O–Na2O–MgO–CaF2system. Zn-containing silicates, such as hardystonite (Ca2ZnSi2O7) and willemite (Zn2SiO4), were also developed either by directly mixing ZnOpowders with the glass, or by embedding them in the preceramic polymer, as additional fillers. KW - Additive manufacturing KW - Ceramics PY - 2015 DO - https://doi.org/10.1016/j.jeurceramsoc.2014.09.020 SN - 0955-2219 SN - 1873-619X VL - 35 SP - 731 EP - 739 PB - Elsevier Ltd. CY - Oxford AN - OPUS4-34955 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -