TY - JOUR A1 - Darowski, N. A1 - Zizak, I. A1 - Schumacher, G. A1 - Klingelhöffer, Hellmuth A1 - Chen, W. A1 - Neumann, W. T1 - Temperature dependence of x-ray intensity profile FWHM of the gamma' phase in the creep-deformed single crystal superalloy SC16 N2 - High-resolution diffraction using synchrotron x-ray radiation was applied to study γ´ precipitates with an L12 superlattice crystal structure in the single crystal superalloy SC16 after creep deformation at 1223 K with a creep strain of ±0.5% for tensile and compressive loads, respectively. The measurements of full width at half maximum (FWHM) of 001 and 100 γ´ superlattice reflections were performed at various temperatures from ambient temperature to 1173 K in vacuum. The experimental results revealed that the FWHM of both reflections decrease with increasing temperature. It is well-known that changes in particle size and lattice distortion in materials could lead to a variation of FWHM. The observed behaviour is discussed in the light of both the above-mentioned aspects. The decrease in the peak width is mainly attributed to the temperature dependence of the internal strain state. KW - Creep deformation KW - Synchrotron x-ray radiation PY - 2005 DO - https://doi.org/10.1088/0022-3727/38/10A/038 SN - 0022-3727 SN - 1361-6463 VL - 38 IS - 10A SP - A200 EP - A203 PB - IOP Publ. CY - Bristol AN - OPUS4-11967 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Chen, W. A1 - Darowski, N. A1 - Zizak, I. A1 - Schumacher, G. A1 - Klingelhöffer, Hellmuth A1 - Neumann, W. T1 - Lattice distortion in precipitates of single crystal superalloy SC16 under creep deformation N2 - Specimens of single crystal superalloy SC16 were creep deformed at 1223 K along [0 0 1] up to ±0.5% creep strain using stresses of -150 MPa and +150 MPa, respectively. Line widths and peak positions of superlattice reflections were measured by means of X-ray diffraction parallel and perpendicular to the load axis in the temperature range between 293 K and 1173 K. The line widths were found to decrease with the increase of temperature for both directions on the two specimens after tensile and compressive creep deformation. After both kinds of creep deformation the crystal lattice showed tetragonal distortion which decreased with increasing temperature. The tetragonality after tensile creep deformation was larger than unity while it was smaller than unity after compressive creep deformation. The peak positions and widths restored after cooling back to room temperature. The experimental results can qualitatively be explained by the creation of dislocations during deformation and their anisotropic arrangement at the γ/γ' interfaces. KW - Superalloys KW - Creep deformation KW - Lattice distortion PY - 2006 DO - https://doi.org/10.1016/j.nimb.2005.12.032 SN - 0168-583X SN - 1872-9584 VL - 246 IS - 1 SP - 201 EP - 205 PB - Elsevier CY - Amsterdam AN - OPUS4-12498 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Moldovan, R.-P. A1 - Wenzel, B. A1 - Teodoro, R. A1 - Neumann, W. A1 - Dukic-Stefanovic, S. A1 - Kraus, Werner A1 - Rong, P. A1 - Deuther-Conrad, W. A1 - Hey-Hawkins, E. A1 - Krügel, U. A1 - Brust, P. T1 - Studies towards the development of a PET radiotracer for imaging of the P2Y1 receptors in the brain: synthesis, 18F-labeling and preliminary biological evaluation N2 - Purine nucleotides such as ATP and ADP are important extracellular signaling molecules in almost all tissues activating various subtypes of purinoreceptors. In the brain, the P2Y1 receptor (P2Y1R) subtype mediates trophic functions like differentiation and proliferation, and modulates fast synaptic transmission, both suggested to be affected in diseases of the central nervous system. Research on P2Y1R is limited because suitable brain-penetrating P2Y1R-selective tracers are not yet available. Here, we describe the first efforts to develop an 18F-labeled PET tracer based on the structure of the highly affine and selective, non-nucleotidic P2Y1R allosteric modulator 1-(2-[2-(tert-butyl)phenoxy]pyridin-3-yl)-3- [4-(trifluoromethoxy)phenyl]urea (7). A small series of fluorinated compounds was developed by systematic modification of the p-(trifluoromethoxy)phenyl, the urea and the 2-pyridyl subunits of the lead compound 7. Additionally, the p-(trifluoromethoxy)phenyl subunit was substituted by carborane, a boron-rich cluster with potential applicability in boron neutron capture therapy (BNCT). By functional assays, the new fluorinated derivative 1-{2-[2-(tert-butyl)phenoxy]pyridin-3-yl}-3-[4-(2-fluoroethyl) phenyl]urea (18) was identified with a high P2Y1R antagonistic potency (IC50 ¼10 nM). Compound [18F] 18 was radiosynthesized by using tetra-n-butyl ammonium [18F]fluoride with high radiochemical purity, radiochemical yield and molar activities. Investigation of brain homogenates using hydrophilic interaction chromatography (HILIC) revealed [18F]fluoride as major radiometabolite. Although [18F]18 showed fast in vivo metabolization, the high potency and unique allosteric binding mode makes this class of compounds interesting for further optimizations and investigation of the theranostic potential as PET tracer and BNCT agent. KW - Purine P2Y1 receptors KW - Positron emission tomography KW - Brain PET tracers KW - Radiometabolites KW - Micellar chromatography KW - Hydrophilic interaction chromatography PY - 2019 DO - https://doi.org/10.1016/j.ejmech.2019.01.006 SN - 0223-5234 VL - 165 SP - 142 EP - 159 PB - Elsevier CY - Amsterdam AN - OPUS4-47253 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Hoesl, Simone A1 - Neumann, B. A1 - Techritz, Sandra A1 - Sauter, G. A1 - Simon, R. A1 - Schlüter, H. A1 - Linscheid, M. W. A1 - Theruing, F. A1 - Müller, Larissa A1 - Jakubowski, Norbert T1 - Internal standardization of LA-ICP-MS immunoimaging via printing of universal metal spiked inks onto tissue sections N2 - Formalin-fixed paraffin-embedded (FFPE) specimen from biopsy materials are a widespread sample format for pathologists and medical researchers. Pathologists are archiving vast numbers of FFPE samples which can be stored for decades. Conventional immunohistochemical staining (IHC) of biomarkers on FFPE tissue sections is one of the most important analytical techniques for cancer diagnosis and pathology in general. However standardization for IHC samples and quality management is tedious and differs significantly from clinic to clinic. Combining established IHC staining strategies with modern mass spectrometry mediated methods would increase it`s potential and enable access of large FFPE archives for multiplexed quantitation purposes. In this work element mass spectrometry and a new ink-jet printed internal standardization approach was successfully combined with IHC staining to facilitate quantitative multiplex assays for archived FFPE samples. The printing strategy improves elemental image resolution and reproducibility of paraffin embedded breast cancer tissue sections in laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) using conventional IHC staining as a model system to investigate the new capabilities of this technique. For the internal standardization we applied a conventional CD-ink-jet printer to print a metal spiked ink onto the top of thin layer tissue sections with constant density. Printing was carried out in a direct comparison to an iodination of the tissue section as previously described as an alternative standardization method. The use of the printed internal standard allowed correction of the fluctuation during the laser ablation process and compensated instrumental drift effects. Mediated by the ink correction approach we achieved better signal-to-background-ratios (SBR) of 74 and better spatial resolution of 30 µm compared to iodination (SBR=23). This improved performance was demonstrated on tumorous areas in FFPE breast cancer tissue sections and allowing detection of Her-2 in tumorous areas of this tissue with significantly improved contrast. KW - Internal standardization KW - LA-ICP-MS KW - Immuno imaging PY - 2016 DO - https://doi.org/10.1039/c5ja00409h SN - 0267-9477 SN - 1364-5544 VL - 31 IS - 3 SP - 801 EP - 808 AN - OPUS4-35711 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Häusler, Ines A1 - Moeck, P. A1 - Volz, K. A1 - Neumann, W. T1 - Atomically ordered (Mn,Ga) As crystallites on and within GaAs N2 - Metal organic vapor phase epitaxy (MOVPE) of Mn-rich (Mn,Ga)As on (001) oriented GaAs wafers resulted in atomically ordered (Mn,Ga)As crystallites of two morphological kinds, partially embedded on the wafer surface and fully embedded within the single crystalline matrix. While the former were apparently free of defects (other than unavoidable point defects), the latter contained two domains separated by a grain boundary. Since atomic ordering can be modeled by space group symmetry descent considerations (Bärnighausen trees) that start with the space group of the known crystallographic phases of random (Mn,Ga)As alloys with specified chemical compositions, reasonable structure hypotheses have been derived for two atomically ordered Mn0.75Ga0.25As phases that we call the trigonal α' and the monoclinic β' phases. The implications of these structure hypotheses are in agreement with the results of a range of scanning transmission electron microscopy (STEM) and parallel illumination electron diffraction (ED) studies that include quantitative energy dispersive X-ray spectroscopy, X-ray spectroscopic imaging, as well nanobeam diffraction and high angle precession ED. The coexistence of two domains within the fully embedded crystallites is predicted by the corresponding Bärnighausen tree and observed experimentally for the fully embedded crystallites. KW - (Mn,Ga) As crystallites KW - Bärninghausen symmetry trees KW - Precession electron diffraction KW - Scanning nanobeam mapping KW - STEM/TEM imaging PY - 2015 DO - https://doi.org/10.1002/crat.201500310 SN - 0023-4753 SN - 1521-4079 SN - 0232-1300 VL - 50 IS - 12 SP - 967 EP - 973 PB - Wiley-VCH Verlag GmbH & Co. KGaA CY - Weinheim AN - OPUS4-35125 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Häusler, Ines A1 - Moeck, P. A1 - Volz, K. A1 - Neumann, W. T1 - Orientation relationships of Mn0.75Ga0.25As crystallites on and within GaAs determined by scanning nano beam electron diffraction N2 - Mn0.75Ga0.25As crystallites, partially embedded on and fully embedded within a single crystalline matrix of GaAs formed during metal organic vapor phase epitaxy (MOVPE) of Mn-rich (Mn,Ga)As on (001) oriented GaAs wafers. Phase and orientation analysis of these crystallites were performed with scanning nano beam electron diffraction (SNBED). The investigation of plan-view specimens using a liquid nitrogen cooling stage enabled the phase and orientation analysis of partially embedded ferromagnetic a-phase particles. In all specimens the following two orientation relationships (O) between the a-phase particles and the GaAs matrix were determined: O1: [1-2.0] Mn0.75Ga0.25As || [110] GaAs and [10.2] Mn0.75Ga0.25As || [-110] GaAs O2: [10.2] Mn0.75Ga0.25As || [110] GaAs and [1-2.0] Mn0.75Ga0.25As || [-110] GaAs. The study of cross-sectional specimens enabled the analysis of fully embedded crystallites. It could be unambiguously detected that a fully embedded crystallite has the structure of the atomically ordered monoclinic β' phase. The β' phase crystallite consists of two domains which are related in twin positions to each other. The orientation relations of the different particles are illustrated by color coded stereographic projections. KW - (Mn,Ga)As crystallites KW - Scanning nano beam electron diffraction KW - Crystal phase determination KW - Orientation mapping KW - STEM/TEM imaging PY - 2017 DO - https://doi.org/10.1002/crat.201600261 SN - 1521-4079 SN - 0232-1300 VL - 52 IS - 1, Special Issue: Anniversary Issue: 50 Years of Crystal Research & Technology SP - 138 EP - 145 PB - Wiley AN - OPUS4-38939 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Hea, Y. A1 - Esteban-Fernandez, Diego A1 - Neumann, B. A1 - Bergmann, U. A1 - Bierkandt, Frank A1 - Linscheid, M. W. T1 - Application of MeCAT-Click labeling for protein abundance characterization of E. coli after heat shock experiments N2 - In a proof of concept study, metal-coded affinity tags based on click chemistry (MeCAT-Click) were used to analyze the proteome of Escherichia coli (E. coli) in response to heat stress. This allows high labeling efficiency, high detection sensitivity, and multiplex capabilities, which are pivotal for its application to protein quantification. Two approaches are presented for relative quantification of differentially lanthanide-labeled proteins. The first approach uses isotope-labeling, where ESI-MS was utilized to quantify the differentially labeled proteins from different states of E. coli. With this approach, 14 proteins were found with changed abundance, among them five proteins upregulated. In the second approach, differentially labeled samples were separated by two dimensional gel electrophoresis (2 DE) and scanned by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). Comparison of the signal intensities of the different lanthanides was used to quantify different sample states. Based on this information, ESI-MS was used to identify the proteins with different abundance. The sensitivity of LA-ICP-MS allowed us to find one upregulated protein that was nearly invisible by silver staining ("Probable replication endonuclease from retron EC67"). The advantage of this approach is to locate low abundant proteins with differential expression using LA-ICP-MS, which may be overlooked otherwise. Biological significance: This paper demonstrates the successful application of a novel metal labeling strategy to quantify the proteins from complex biological samples. In comparison with former metal labeling strategies, it reduces the steric hindrance and improves the labeling efficiency during the labeling process, which ensure its successful application. This methodology is compatible with both molecular and elemental mass spectrometry. ESI-MS/MS in combination with software-based search allows the identification and relative quantification of labeled proteins. In addition, LA-ICP-MS helps to locate the labeled proteins in 2-DE gels with superior detection capability, thus, target proteins with low abundance can be precisely followed. Its excellent sensitivity allows one to track the proteins of interest that are barely visible by silver staining. KW - Protein quantification KW - Heat shock response KW - Ln-MeCAT-Click labeling KW - nanoLC-ESI-MS/MS KW - 2-D electrophoresis KW - LA-ICP-MS PY - 2016 DO - https://doi.org/10.1016/j.jprot.2015.12.010 SN - 1874-3919 VL - 136 SP - 68 EP - 76 PB - Elsevier B.V. CY - Amsterdam AN - OPUS4-35837 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Schumacher, G. A1 - Darowski, N. A1 - Zizak, I. A1 - Klingelhöffer, Hellmuth A1 - Neumann, W. T1 - Two-stage relaxation of damage structure in strongly creep-deformed single crystal superalloy SC16 measured by means of X-ray diffraction KW - Superalloys KW - SC16 KW - Creep-deformation KW - Relaxation KW - X-ray diffraction PY - 2009 DO - https://doi.org/10.1016/j.scriptamat.2008.09.009 SN - 1359-6462 SN - 1872-8456 VL - 60 IS - 2 SP - 88 EP - 91 PB - Elsevier CY - Oxford AN - OPUS4-18304 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Neumann, Eberhard A1 - Nabel, Eberhard A1 - Leisner, W. A1 - Wüstenberg, Hermann T1 - Ultraschallprüfung von Schweißverbindungen austenitischer Stähle PY - 1974 SN - 0025-5300 VL - 16 IS - 12 SP - 395 PB - Carl Hanser Verlag CY - München AN - OPUS4-8108 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Neumann, L. A1 - Jakobs, F. A1 - Spelthann, S. A1 - Zaremba, D. A1 - Radunz, Sebastian A1 - Resch-Genger, Ute A1 - Evert, R. A1 - Kielhorn, J. A1 - Kowalsky, W. A1 - Johannes, H. H. T1 - Integration of beta-NaYF4 Upconversion Nanoparticles into Polymers for Polymer Optical Fiber Applications N2 - Producing active polymer optical fibers (POFs) is a key step towards new applications such as fluorescent fiber solar concentrators (FFSCs), sensors, contactless coupling devices, or fiber integrated light sources and lasers. Therefore, integration of fluorescent nanoparticles into the polymer matrix is necessary and becomes accessible via in situ polymerization. For optical applications, the polymer has to fulfill various requirements such as chemical and physical stability, optical transparency in the application-relevant spectral region as well as a good synthetic accessibility. A common material for these is poly(methyl methacrylate) (PMMA). The beta-phase NaYF4 : Yb3+, Er3+ upconversion nanoparticles (UCNP) were synthesized from the rare earth salts via thermal decomposition method in high-boiling point solvent 1-octadecene and capping agent oleic acid. Current results show hazy samples of the polymer with integrated nanoparticles made from monomer solution of methyl methacrylate. However, further optical tuning such as increasing the transparency of the bulk samples by changing the monomer solution to non-polar n-butyl methacrylate (nButMA) or cyclohexyl methacrylate (CHMA) or further optimization of the UCNP shell could lead to more suitable polymer bulk samples. KW - Active fibers KW - Rare earth nanoparticles KW - Upconversion KW - Polymer PY - 2018 UR - https://journals.ioffe.ru/articles/46830 DO - https://doi.org/10.1134/S0030400X18110206 SN - 0030-400X VL - 125 IS - 5 SP - 711 EP - 715 PB - Pleiades Publishing CY - New York, NY AN - OPUS4-47167 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - El-Khatib, A. H. A1 - Radbruch, H. A1 - Trog, S. A1 - Neumann, B. A1 - Paul, F. A1 - Koch, A. A1 - Linscheid, M. W. A1 - Jakubowski, Norbert A1 - Schellenberger, E. T1 - Gadolinium in human brain sections and colocalization with other elements N2 - Recent recommendations by the Food and Drug Administration1 and the European Medicines Agency2 are to limit the clinical use of linear gadolinium-based contrast agents (GBCAs) due to convincing evidence of deposition in tissues. Macrocyclic GBCA continued to be considered safe, provided that patients have normal renal function. To date, given the low sensitivity of conventional MRI, there has been a debate about the signal increase following the injections of a macrocyclic GBCA. KW - Gadolinium PY - 2019 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-471309 DO - https://doi.org/10.1212/NXI.0000000000000515 SN - 2332-7812 VL - 6 IS - 1 SP - e515, 1 EP - 3 PB - American Academy of Neurology AN - OPUS4-47130 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Waiblinger, H. U. A1 - Bartsch, D. A1 - Brockmeyer, J. A1 - Bruenen-Nieweler, C. A1 - Busch, U. A1 - Haase, I. A1 - Hahn, A. A1 - Haarmann, M. A1 - Hauser, W. A1 - Huber, I. A1 - Jany, K. D. A1 - Kirmse, N. A1 - Lindeke, S. A1 - Neumann, K. A1 - Naumann, H. A1 - Paschke, A. A1 - Pietsch, K. A1 - Pöpping, B. A1 - Reiting, R. A1 - Schroeder, U. A1 - Schwägele, F. A1 - Weller, Michael G. A1 - Zagon, J. T1 - Methods of differentiating animal species in foods – Status quo N2 - Work on standardising methods in the field of animal species differentiation has been intensified in Germany in recent years, not least due to the horsemeat scandal in 2013. Even though there are now hardly ever any positive findings any more in examinations to detect horse adulterations in foods such as lasagne, animal species differentiation altogether ranks high in detecting adulteration of foods. This article therefore summarises the current status of analytical techniques used in Germany with standardisation at German level. It has been established by the working group “Biochemical and Molecular Biological Analytics” of the Lebensmittelchemische Gesellschaft (Food Chemistry Society within the German Chemical Society) with support of experts in the working group “Molecular biology techniques for differentiating plant and animal species” (§ 64 of the German Food and Feed Code – LFGB) and the “Immunology and molecular biology” task force of the food hygiene and Food of animal origin working group (ALTS), both from Germany. KW - Animal species differentiation KW - Fish species KW - PCR KW - Standardisation KW - DNA chip KW - Multiplex methods KW - Digital PCR KW - ELISA methods KW - Immunoassays KW - LC-MS/MS KW - Reference materials KW - Microarrays KW - LAMP KW - Interlaboratory studies PY - 2017 SN - 0179-2415 VL - 97 IS - 1 SP - 50 EP - 55 PB - Deutscher Fachverlag GmbH CY - Frankfurt AN - OPUS4-39264 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Waiblinger, H. U. A1 - Bartsch, D. A1 - Brockmeyer, J. A1 - Bruenen-Nieweler, C. A1 - Busch, U. A1 - Haase, I. A1 - Hahn, A. A1 - Haarmann, M. A1 - Hauser, W. A1 - Huber, I. A1 - Jany, K. D. A1 - Kirmse, N. A1 - Lindeke, S. A1 - Neumann, K. A1 - Naumann, H. A1 - Paschke, A. A1 - Pietsch, K. A1 - Pöpping, B. A1 - Reiting, R. A1 - Schroeder, U. A1 - Schwägele, F. A1 - Weller, Michael G. A1 - Zagon, J. T1 - Methods of differentiating animal species in food - Status quo N2 - In the field of animal species differentiation, work on standardizing methods has been intensified in Germany in recent years, not least due to the horsemeat scandal in 2013. Even though there are now hardly ever any positive findings anymore in examinations to detect horse adulterations in foods such as lasagne, animal species differentiation altogether ranks high in detecting adulteration of foods. This article, therefore, summarises the current status of analytical techniques used in Germany with standardization at German level. It has been established by the working group "Biochemical and Molecular Biological Analytics" of the Lebensmittelchemische Gesellschaft (Food Chemistry Society within the German Chemical Society) with support of experts in the working group “Molecular biology techniques for differentiating plant and animal species" (§64 of the German Food and Feed Code - LFGB) and the "Immunology and molecular biology" task force of the food hygiene and food of animal origin working group (ALTS), both from Germany. KW - Animal species differentiation KW - Fish species KW - PCR KW - ELISA KW - LC-MS/MS PY - 2017 IS - 3 SP - 29 EP - 36 PB - Deutscher Fachverlag GmbH CY - Frankfurt am Main AN - OPUS4-43485 LA - mul AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Waiblinger, H. U. A1 - Brockmeyer, J. A1 - Bruenen-Nieweler, C. A1 - Busch, U. A1 - Haase, I. A1 - Hahn, A. A1 - Haarmann, M. A1 - Hauser, W. A1 - Huber, I. A1 - Jany, K. D. A1 - Kirmse, N. A1 - Lindeke, S. A1 - Neumann, K. A1 - Naumann, H. A1 - Paschke, A. A1 - Pietsch, K. A1 - Pöpping, B. A1 - Reiting, R. A1 - Schroeder, U. A1 - Schwägele, F. A1 - Weller, Michael G. A1 - Zagon, J. T1 - Methoden zur Differenzierung von Tierarten in Lebensmitteln – Status quo N2 - Nicht zuletzt bedingt durch den Pferdefleischskandal im Jahr 2013 wurden in Deutschland die Aktivitäten bei der Methodenstandardisierung im Bereich der Tierarten-Differenzierung in den vergangenen Jahren intensiviert. Wenn auch positive Befunde bei dem Nachweis von Bestandteilen aus Pferd in Lebensmitteln wie Lasagne derzeit so gut wie nicht mehr anzutreffen sind, so hat die Tierartendifferenzierung insgesamt beim Nachweis von Verfälschungen in Lebensmitteln einen hohen Stellenwert. Diese Arbeit fasst daher den aktuellen Stand der Analytik in Deutschland mit Schwerpunkt bei der Standardisierung zusammen. Sie wurde erstellt durch die Arbeitsgruppe „Biochemische und molekularbiologische Analytik“ der Lebensmittelchemischen Gesellschaft mit Unterstützung von Experten der Arbeitsgruppe „Molekularbiologische Methoden zur Pflanzen- und Tierartendifferenzierung“ (§ 64 LFGB) sowie der ALTS-Arbeitsgruppe „Immunologie und Molekularbiologie“ (jeweils D). KW - ELISA KW - PCR KW - Multiplex KW - DNA-Chip KW - Fischarten KW - Standardisierung KW - Molekularbiologie KW - Immunoassay KW - Hybridisierung KW - Digitale PCR KW - LC-MS/MS KW - Massenspektrometrie KW - Schnellmethoden KW - Screening KW - Milch KW - Microarray KW - LAMP KW - Laborvergleichuntersuchungen KW - Referenzmaterialien KW - Standardverfahren PY - 2017 SN - 0015-363X IS - 1 SP - 97 EP - 102 PB - Deutscher Fachverlag GmbH CY - Frankfurt AN - OPUS4-39038 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -