TY - CONF
A1 - Vogl, Jochen
T1 - Key Comparison on isotope ratio determinations - K98/P134 Pb isotope ratios
T2 - CCQM, IAWG Meeting
CY - Paris, France
DA - 2012-04-16
PY - 2012
AN - OPUS4-25947
LA - deu
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - CONF
A1 - Vogl, Jochen
T1 - Characterization of isotope and matrix reference materials using ICP-MS instruments
T2 - 50-Jarig Jubileum Werkgroep Atoomspectrometrie
CY - Tilburg, Netherlands
DA - 2012-06-07
PY - 2012
AN - OPUS4-25948
LA - deu
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - CONF
A1 - Vogl, Jochen
T1 - Herkunftsbestimmung von Kalken
T2 - GDCh Tagung Bauchemie 2011
CY - Hamburg, Germany
DA - 2011-10-06
PY - 2011
AN - OPUS4-25952
LA - deu
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - CONF
A1 - Vogl, Jochen
T1 - Reference materials for isotope research
T2 - 13th International Symposium on Biological and Environmental Reference Materials, BERM 13
CY - Vienna, Austria
DA - 2012-06-25
PY - 2012
AN - OPUS4-26134
LA - deu
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - CONF
A1 - Vogl, Jochen
T1 - Isotopenanalytik mit ICP-MS und TIMS in Nahrungsmitteln, Medizin und Umwelt
T2 - DGMS 2013, Workshop Einführung in die anorganische Massenspektrometrie
CY - Berlin, Germany
DA - 2013-03-10
PY - 2013
AN - OPUS4-27894
LA - deu
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - CONF
A1 - Vogl, Jochen
T1 - Isotope Dilution Mass Spectrometry - A primary method of measurement and its role for RM certification
T2 - DGMS 2013, Workshop Einführung in die anorganische Massenspektrometrie
CY - Berlin, Germany
DA - 2013-03-10
PY - 2013
AN - OPUS4-27895
LA - deu
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - CONF
A1 - Vogl, Jochen
T1 - Metrology for boron isotope analysis
T2 - Boron Isotope Workshop, Goldschmidt Conference 2013
CY - Florence, Italy
DA - 2013-08-24
PY - 2013
AN - OPUS4-29083
LA - deu
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - CONF
A1 - Vogl, Jochen
T1 - Production and certification of Pd and Pt single spikes
T2 - Goldschmidt Conference 2013
CY - Florence, Italy
DA - 2013-08-25
PY - 2013
AN - OPUS4-29084
LA - deu
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - JOUR
A1 - Vogl, Jochen
A1 - Rosner, Martin
A1 - Pritzkow, Wolfgang
T1 - The need for new isotope reference materials
N2 - Isotope reference materials are needed to calibrate and validate analytical procedures used for the determination of isotope amount ratios, procedurally defined isotope ratios or so-called δ values. In contrast to the huge analytical progress in isotope ratio analytics, the production of isotope reference materials has not kept pace with the increasing needs of isotope analysts. Three representative isotope systems are used to explain the technical and non-technical difficulties and drawbacks, on one hand, and to demonstrate what can be achieved at its best, on the other hand. A clear statement is given that new isotope reference materials are needed to obtain traceable and thus comparable data, which is essential for all kinds of isotope research. The range of available isotope reference materials and δ reference materials should be increased and matrix reference materials certified for isotope compositions or δ values, which do not exist yet, should be provided.
KW - Isotope reference materials
KW - Delta reference materials
KW - Synthetic isotope mixtures
KW - Mass spectrometry
KW - Comparability
KW - Traceability
KW - Measurement uncertainty
PY - 2013
DO - https://doi.org/10.1007/s00216-012-6605-3
SN - 1618-2642
SN - 1618-2650
VL - 405
IS - 9
SP - 2763
EP - 2770
PB - Springer
CY - Berlin
AN - OPUS4-28169
LA - eng
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - JOUR
A1 - Vogl, Jochen
A1 - Paz, B.
A1 - Koenig, Maren
A1 - Pritzkow, Wolfgang
T1 - A modified lead-matrix separation procedure shown for lead isotope analysis in Trojan silver artefacts as an example
N2 - A modified Pb–matrix separation procedure using NH4HCO3 solution as eluent has been developed and validated for determination of Pb isotope amount ratios by thermal ionization mass spectrometry. The procedure is based on chromatographic separation using the Pb·Spec resin and an in-house-prepared NH4HCO3 solution serving as eluent. The advantages of this eluent are low Pb blanks (<40 pgmL-1) and the property that NH4HCO3 can be easily removed by use of a heating step (>60 °C). Pb recovery is >95 % for water samples. For archaeological silver samples, however, the Pb recovery is reduced to approximately 50 %, but causes no bias in the determination of Pb isotope amount ratios. The validated procedure was used to determine lead isotope amount ratios in Trojan silver artefacts with expanded uncertainties (k=2) <0.09 %.
KW - Analyte-matrix separation
KW - Mass spectrometry
KW - Pb isotope ratio thermal ionization mass spectrometry
KW - Archaeometry
PY - 2013
DO - https://doi.org/10.1007/s00216-012-6323-x
SN - 1618-2642
SN - 1618-2650
VL - 405
IS - 9
SP - 2995
EP - 3000
PB - Springer
CY - Berlin
AN - OPUS4-28170
LA - eng
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - JOUR
A1 - Vogl, Jochen
T1 - Advances in isotope ratio mass spectrometry and required isotope reference materials
N2 - The article gives a condensed version of the keynote lecture held at the International Mass Spectrometry Conference 2012 in Kyoto. Starting with some examples for isotope research the key requirements for metrologically valid procedures enabling traceable and comparable isotope data are discussed. Of course multi-collector mass spectrometers are required which offer sufficiently high isotope ratio precision for the intended research work. Following this, corrections for mass fractionation/discrimination, validation of the analytical procedure including chemical sample preparation and complete uncertainty budgets are the most important issues for obtaining a metrologically valid procedure for isotope ratio determination. Only the application of such metrologically valid procedures enables the generation of traceable and comparable isotope data. To realize this suitable isotope and/or δ-reference materials are required, which currently are not sufficiently available for most isotope systems. Boron is given as an example, for which the situation regarding isotope and δ-reference materials is excellent. Boron may therefore serve as prototype for other isotope systems.
KW - Isotope reference materials
KW - Delta reference materials
KW - Traceability
KW - Comparability
KW - Measurement uncertainty
KW - Synthetic isotope mixtures
KW - Mass fractionation
KW - Mass discrimination
PY - 2013
DO - https://doi.org/10.5702/massspectrometry.S0020
SN - 2187-137X
SN - 2186-5116
VL - 2
IS - 50020
SP - 1
EP - 7
AN - OPUS4-28562
LA - eng
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - CONF
A1 - Vogl, Jochen
T1 - Reference Materials and Metrological Principles for Isotope Research
T2 - 15th Beijing Conference and Exhibition on Instrumental Analysis (BCEIA 2013)
CY - Beijing, China
DA - 2013-10-23
PY - 2013
AN - OPUS4-29295
LA - deu
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - CONF
A1 - Vogl, Jochen
T1 - CCQM-K98/P134 - Pb isotope amount ratios in bronze
T2 - CCQM IAWG Meeting
CY - Pretoria, South Africa
DA - 2013-11-05
PY - 2013
AN - OPUS4-29296
LA - deu
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - CONF
A1 - Riebe, Gundel
A1 - Klingbeil, Patrick
A1 - Pritzkow, Wolfgang
A1 - Vogl, Jochen
T1 - Erfahrungen mit mikrowelleninduzierten Aufschluss-Verfahren für die Elementspurenanalytik
T2 - MLS-Tagesseminar
CY - Berlin, Deutschland
DA - 2001-03-19
PY - 2001
AN - OPUS4-1111
LA - deu
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - CONF
A1 - Riebe, Gundel
A1 - Ostermann, Markus
A1 - Pritzkow, Wolfgang
A1 - Vogl, Jochen
T1 - Combination of sophisticated sample digestion methods and highly accurate determination procedures shown for Sulphur in oil and Cadmium and Lead in sediment
T2 - Internationale Konferenz "Trends in Sample Preparation 2002"
CY - Seggau, Austria
DA - 2002-06-30
PY - 2002
AN - OPUS4-1398
LA - eng
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - CONF
A1 - Ostermann, Markus
A1 - Janisch, Nadine
A1 - Vogl, Jochen
T1 - On the determination of the moisture content in different matrix materials
T2 - Internationale Konferenz "Trends in Sample Preparation 2002"
CY - Seggau, Austria
DA - 2002-06-30
PY - 2002
AN - OPUS4-1399
LA - eng
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - GEN
A1 - Paz, B.
A1 - Meyer, H.-P.
A1 - Varychev, A.
A1 - Rosner, M.
A1 - Vogl, Jochen
A1 - Behrendt, S.
ED - Treister, M.
ED - Yablonsky, L.
T1 - Археометрические исследования стеклянных сосудов из погребений ранних кочевников Южного Приуралья
T1 - Archäometrische Untersuchungen an achaimenidischen Glasgefäßen aus den Gräbern der frühen Nomaden des südlichen Urals
N2 - Die untersuchten Gläser lassen sich in drei Gruppen einteilen. Die beiden Fragmente aus der Nekropole von Pjatimary deuten auf eine frühe Herstellungszeit hin und lassen sich mit eisenzeitlichen Fragmenten iranischer Herkunft vergleichen. Die Glasfunde aus der Nekropole Filippovka bestehen aus völlig unterschiedlichen Glasmaterialien und müssen einer späteren Herstellungszeit zugeordnet werden. Sowohl die unterschiedlichen Rezepturen als auch der definitive Hinweis auf verschiedene Rohstoffquellen zur Herstellung der untersuchten Gläser, lassen ein breitgefächertes Netz von weitreichenden Handelsbeziehungen erkennen.
KW - Archäometrie
KW - Isotopenverhältnisse Strontium und Blei
KW - Elementanalyse
KW - Massenspektrometrie
KW - Herkunft
PY - 2012
SN - 978-5-903011-85-8
VL - 1
SP - 262
EP - 267
PB - TAUS
CY - Moskau
AN - OPUS4-26899
LA - rus
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - JOUR
A1 - Rienitz, O.
A1 - Schiel, D.
A1 - Görlitz, V.
A1 - Jährling, R.
A1 - Vogl, Jochen
A1 - Lara-Manzano, J.V.
A1 - Zon, A.
A1 - Fung, W.-H.
A1 - Buzoianu, M.
A1 - De Sena, R.C.
A1 - Dos Reis, L.A.
A1 - Valiente, L.
A1 - Yim, Y.-H.
A1 - Hill, S.
A1 - Champion, R.
A1 - Fisicaro, P.
A1 - Bing, W.
A1 - Turk, G.C.
A1 - Winchester, M. R.
A1 - Saxby, D.
A1 - Merrick, J.
A1 - Hioki, A.
A1 - Miura, T.
A1 - Suzuki, T.
A1 - Linsky, M.
A1 - Barzev, A.
A1 - Máriássy, M.
A1 - Cankur, O.
A1 - Ari, B.
A1 - Tunc, M.
A1 - Konopelko, L.A.
A1 - Kustikov, Y.A.
A1 - Bezruchko, M.
T1 - Final report on CCQM-K87: Mono-elemental calibration solutions
N2 - The aim of this comparison was to demonstrate the capability of national metrology institutes to measure elemental mass fractions at a level of w(E) ≈ 1 g/kg as found in almost all mono-elemental calibration solutions. These calibration solutions represent an important link in traceability systems in inorganic analysis. Virtually all traceable routine measurements are linked to the SI through these calibration solutions. Every participant was provided with three solutions of each of the three selected elements chromium, cobalt and lead. This comparison was a joint activity of the Inorganic Analysis Working Group (IAWG) and the Electrochemical Analysis Working Group (EAWG) of the CCQM and was piloted by the Physikalisch-Technische Bundesanstalt (PTB, Braunschweig, Germany) with the help of the Bundesanstalt für Materialforschung und -prüfung (BAM, Berlin, Germany), the Centro Nacional de Metrología (CENAM, Querétaro, Mexico) and the National Institute of Standards and Technology (NIST, Gaithersburg, USA).
A small majority of participants applied inductively coupled plasma optical emission spectrometry (ICP OES) in combination with a variety of calibration strategies (one-point-calibration, bracketing, calibration curve, each with and without an internal standard). But also IDMS techniques were carried out on quadrupole, high resolution and multicollector ICP-MS machines as well as a TIMS machine. Several participants applied titrimetry. FAAS as well as ICP-MS combined with non-IDMS calibration strategies were used by at least one participant. The key comparison reference values (KCRV) were agreed upon during the IAWG/EAWG meeting in November 2011 held in Sydney as the added element content calculated from the gravimetric sample preparation. Accordingly the degrees of equivalence were calculated. Despite the large variety of methods applied no superior method could be identified. The relative deviation of the median of the participants' results from the gravimetric reference value was equal or smaller than 0.1% (with an average of 0.05%) in the case of all three elements.
KW - CCQM
KW - Metrology
KW - IDMS
PY - 2012
DO - https://doi.org/10.1088/0026-1394/49/1A/08010
SN - 0026-1394
SN - 1681-7575
VL - 49
IS - 08010, 1A (Technical Supplement 2012)
SP - 1
EP - 104
PB - Inst. of Physics Publ.
CY - Bristol
AN - OPUS4-30458
LA - eng
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - JOUR
A1 - Vogl, Jochen
A1 - Rosner, Martin
T1 - Production and certification of a unique set of isotope and delta reference materials for Boron isotope determination in geochemical, environmental and industrial materials
N2 - Isotopic reference materials are essential to enable reliable and comparable isotope data. In the case of boron only a very limited number of such materials is available, thus preventing adequate quality control of measurement results and validation of analytical procedures. To address this situation a unique set of two boron isotope reference materials (ERM-AE102a and -AE104a) and three offset δ11B reference materials (ERM-AE120, -AE121 and -AE122) were produced and certified. The present article describes the production and certification procedure in detail. The isotopic composition of all the materials was adjusted by mixing boron parent solutions enriched in 10B or 11B with a boron parent solution having a natural isotopic composition under full gravimetric control. All parent solutions were analysed for their boron concentration as well as their boron isotopic composition by thermal ionisation mass spectrometry (TIMS) using isotope dilution as the calibration technique. For all five reference materials the isotopic composition obtained on the basis of the gravimetric data agreed very well with the isotopic composition obtained from different TIMS techniques. Stability and homogeneity studies that were performed showed no significant influence on the isotopic composition or on the related uncertainties. The three reference materials ERM-AE120, ERM-AE121 and ERM-AE122 are the first reference materials with natural δ11B values not equal to 0. The certified δ11B values are -20.2 for ERM-AE120, 19.9 for ERM-AE121 and 39.7 for ERM-AE122, each with an expanded uncertainty (k = 2) of 0.6. These materials were produced to cover about three-quarters of the known natural boron isotope variation. The 10B enriched isotope reference materials ERM-AE102a and ERM-AE104a were produced for industrial applications utilising 10B for neutron shielding purposes. The certified 10B isotope abundances are 0.29995 for ERM-AE102a and 0.31488 for ERM-AE104a with expanded uncertainties (k = 2) of 0.00027 and 0.00028, respectively. Together with the formerly certified ERM-AE101 and ERM-AE103 a unique set of four isotope reference materials and three offset δ11B reference materials for boron isotope determination are now available from European Reference Materials.
KW - Boron isotope variations
KW - Delta-scale
KW - Stable isotopes
KW - Isotope reference materials
KW - Delta reference materials
KW - Metrology in chemistry
KW - Absolute isotope abundance
PY - 2012
DO - https://doi.org/10.1111/j.1751-908X.2011.00136.x
SN - 1639-4488
SN - 1751-908X
VL - 36
IS - 2
SP - 161
EP - 175
PB - Blackwell
CY - Oxford
AN - OPUS4-26260
LA - eng
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - CONF
A1 - Völling, E.
A1 - Reifarth, N.
A1 - Vogl, Jochen
ED - Nosch, M.-L.
ED - Laffineur, R.
T1 - The intercultural context of treasure A in Troy - Jewellery and textiles
N2 - At the end of May 1873, Heinrich Schliemann recovered Treasure A in Troy. He brought all the metal artifacts illegally to Athens and published his iscoveries one year later. Then he bequeathed the Trojan finds to Berlin where from 1881 onwards, Treasure A was exhibited in the Museum of Arts and Crafts (later Gropius Bau). Hubert. Schmidt inventoried and catalogued the Trojan remains in 1902 without the so-called “Dubletten” (duplicates). The transfer of the Treasure trove in 1945 to former Leningrad (St. Petersburg) and Moscow is well known, but there was a partial restoration of the looted art from the former Soviet Union back to the former GDR: eight out of eleven silver vessels of Treasure A came via Leipzig in 1979 finally back to Berlin’s Museum für Vor- und Frühgeschichte, Stiftung Preussischer Kulturbesitz in 1994. During its safe keeping in Leningrad and Leipzig, these silver jars remained ignored in the boxes in which they were transported, a Situation, which today permits them to be investigated almost in their condition of discovery. The study of the Originals allowed Information to be gleaned about their manufacture and offered opportunities for various analyses. After the gold jewellery came to light, technical data and an archaeological appraisal of the Trojan gold kept in the Pushkin Museum of Fine Arts in Moscow could be published in 1996. The considerable quantity of the outstanding gold artifacts of Treasure A was deposited inside the great silver vessel Sch 5873 and listed by Heinrich Schliemann.
T2 - 13th International Aegean Conference
CY - Copenhagen, Denmark
DA - 21.04.2010
PY - 2012
SN - 978-90-429-2665-3
SP - 531
EP - 538
PB - Peeters Publishers
CY - Liège, Belgium
AN - OPUS4-26408
LA - eng
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - JOUR
A1 - Vogl, Jochen
T1 - Measurement uncertainty in single, double and triple isotope dilution mass spectrometry
N2 - Triple IDMS has been applied for the first time to the quantification of element concentrations. It has been compared with single and double IDMS obtained on the same sample set in order to evaluate the advantages and disadvantages of triple IDMS over single and double IDMS as an analytical reference procedure. The measurement results of single, double and triple IDMS are indistinguishable, considering rounding due to the individual measurement uncertainties. As expected, the relative expanded uncertainties (k = 2) achieved with double IDMS (0.08 %) are dramatically smaller than those obtained with single IDMS (1.4 %). Triple IDMS yields the smallest relative expanded uncertainties (k = 2, 0.077 %) unfortunately at the expense of a much higher workload. Nevertheless triple IDMS has the huge advantage that the isotope ratio of the spike does not need to be determined. Elements with high memory effects, highly enriched spikes or highest metrological requirements may be typical applications for triple IDMS.
KW - Single IDMS
KW - Double IDMS
KW - Triple IDMS
KW - Measurement uncertainty
KW - Cd mass fraction
PY - 2012
DO - https://doi.org/10.1002/rcm.5306
SN - 0951-4198
SN - 1097-0231
VL - 26
IS - 3
SP - 275
EP - 281
PB - Wiley
CY - Chichester
AN - OPUS4-25292
LA - eng
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - JOUR
A1 - Klingbeil, Patrick
A1 - Vogl, Jochen
A1 - Pritzkow, Wolfgang
A1 - Riebe, Gundel
A1 - Müller, J.
T1 - Comparative studies on the certification of reference materials by ICPMS and TIMS using isotope dilution procedures
N2 - A comparison of different isotope dilution mass spectrometric (IDMS) procedures using inductively coupled plasma mass spectrometry (ICPMS) and thermal ionization mass spectrometry (TIMS) was carried out to examine the degree of equivalence between the used procedures in terms of requirements for reference material certification. The comparison was based on the measurement results and their uncertainties. The sample used in this study is a pure zinc metal to be certified by the Bureau Communie de Référence (BCR) for amount contents of different trace elements. This study focuses on cadmium and thallium. The TIMS values contributed to the certified values. To guarantee identical conditions as far as possible for the procedures under investigation, the samples were split into subsamples after spiking and digestion took place. Thus, every IDMS procedure started with an identical set of samples. In total, four different IDMS procedures and one external calibration procedure using internal standardization as an example of routine analysis were applied. The IDMS procedures divide in a group with and a group without trace/matrix separation. Multicollector TIMS (TI-MC-MS) and multicollector ICPMS (ICP-MC-MS) were used in combination with trace/matrix separation, whereas quadrupole ICPMS (ICP-QMS) and ICP-MC-MS were also applied to nonseparated samples. All IDMS results agree well within their combined uncertainties, while some results from the external calibration procedure do not. IDMS results obtained by ICPMS without separation are comparable to those obtained by TI-MC-MS with separation regarding precision and accuracy. The smallest uncertainties were achieved using ICP-MC-MS in combination with trace/matrix separation.
KW - ICP-MS
KW - TIMS
KW - IDMS
KW - multi-collector
KW - uncertainty budget
KW - Certification
KW - reference material
PY - 2001
DO - https://doi.org/10.1021/ac001278c
SN - 0003-2700
SN - 1520-6882
VL - 73
IS - 8
SP - 1881
EP - 1888
PB - American Chemical Society
CY - Washington, DC
AN - OPUS4-909
LA - eng
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - JOUR
A1 - You, Zengchao
A1 - Winckelmann, Alexander
A1 - Vogl, Jochen
A1 - Recknagel, Sebastian
A1 - Abad Andrade, Carlos Enrique
T1 - Determination of calcium, iron, and selenium in human serum by isotope dilution analysis using nitrogen microwave inductively coupled atmospheric pressure plasma mass spectrometry (MICAP-MS)
N2 - In this study, we demonstrate the applicability of nitrogen microwave inductively coupled atmospheric pressure mass spectrometry (MICAP-MS) for Ca, Fe, and Se quantification in human serum using isotope dilution (ID) analysis. The matrix tolerance of MICAP-MS in Na matrix was investigated, uncovering that high Na levels can suppress the signal intensity. This suppression is likely due to the plasma loading and the space charge effect. Moreover, 40Ca and 44Ca isotopic fractionation was noted at elevated Na concentration. Nine certified serum samples were analyzed using both external calibration and ID analysis. Overestimation of Cr, Zn, As, and Se was found in the results of external calibration, which might be resulted from C-induced polyatomic interference and signal enhancement, respectively. Further investigations performed with methanol showed a similar enhancement effect for Zn, As, and Se, potentially supporting this assumption. The mass concentrations determined with ID analysis show metrological compatibility with the reference values, indicating that MICAP-MS combined with ID analysis can be a promising method for precise Ca, Fe, and Se determination. Moreover, this combination reduces the influences of matrix effects, broadening the applicability of MICAP-MS for samples with complex matrix.
KW - Selenium
KW - Nitrogen microwave inductively coupled atmospheric pressure mass spectrometry
KW - Isotope dilution
KW - Human serum
KW - Calcium
KW - Iron
PY - 2024
UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-598664
DO - https://doi.org/10.1007/s00216-024-05274-0
SN - 1618-2642
SP - 3117
EP - 3125
PB - Springer
CY - Berlin
AN - OPUS4-59866
LA - eng
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - JOUR
A1 - Knobbe, N.
A1 - Vogl, Jochen
A1 - Pritzkow, Wolfgang
A1 - Panne, Ulrich
A1 - Fry, H.
A1 - Lochotzke, H.M.
A1 - Preiss-Weigert, A.
T1 - C and N stable isotope variation in urine and milk of cattle depending on the diet
N2 - The stable carbon and nitrogen isotopic composition of urine and milk samples from cattle under different feeding regimes were analysed over a period of six months. The isotope ratios were measured with isotope ratio mass spectrometry (IRMS). The δ13C values of milk and urine were dependent on different feeding regimes based on C3 or C4 plants. The δ13C values are more negative under grass feeding than under maize feeding. The δ13C values of milk are more negative compared to urine and independent of the feeding regime. Under grass feeding the analysed milk and urine samples are enriched in 13C relative to the feed, whereas under maize feeding the 13C/12C ratio of urine is in the same range and milk is depleted in 13C relative to the diet. The difference between the 15N/14N ratios for the two feeding regimes is less pronounced than the 13C/12C ratios. The δ15N values in urine require more time to reach the new equilibrium, whereas the milk samples show no significant differences between the two feeding regimes.
KW - Cattle
KW - Urine
KW - Milk
KW - Feeding regime
KW - Stable isotope
PY - 2006
DO - https://doi.org/10.1007/s00216-006-0644-6
SN - 1618-2642
SN - 1618-2650
VL - 386
IS - 1
SP - 104
EP - 108
PB - Springer
CY - Berlin
AN - OPUS4-12746
LA - eng
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - JOUR
A1 - Abad Andrade, Carlos Enrique
A1 - Florek, S.
A1 - Becker-Ross, H.
A1 - Huang, M.-D.
A1 - Heinrich, Hans-Joachim
A1 - Recknagel, Sebastian
A1 - Vogl, Jochen
A1 - Jakubowski, Norbert
A1 - Panne, Ulrich
T1 - Determination of boron isotope ratios by high-resolution continuum source molecular absorption spectrometry using graphite furnace vaporizers
N2 - Boron isotope amount ratios n(10B)/n(11B) have been determined by monitoring the absorption spectrum of boron monohydride (BH) in a graphite furnace using high-resolution continuum source molecular absorption spectrometry (HR-CS-MAS). Bands (0→0) and (1→1) for the electronic transition X1Σ+ → A1Π were evaluated around wavelengths 433.1 nm and 437.1 nm respectively. Clean and free of memory effect molecular spectra of BH were recorded. In order to eliminate the memory effect of boron, a combination of 2% (v/v) hydrogen gas in argon and 1% trifluoromethane in argon, an acid solution of calcium chloride and mannitol as chemical modifiers was used. Partial least square regression (PLS) for analysis of samples and reference materials were applied. For this, a spectral library with different isotopes ratios for PLS regression was built. Results obtained around the 433.1 nm and 437.1 nm spectral regions are metrologically compatible with those reported by mass spectrometric methods. Moreover, for the evaluated region of 437 nm, an accuracy of 0.15‰ is obtained as the average deviation from the isotope reference materials. Expanded uncertainties with a coverage factor of k = 2 range between 0.15 and 0.44‰. This accuracy and precision are compatible with those obtained by mass spectrometry for boron isotope ratio measurements.
KW - Boron isotopes
KW - Isotope ratios
KW - Boron monohydride
KW - Molecular absorption
KW - High-resolution continuum source absorption spectrometry
KW - Graphite furnace
KW - Memory effect
KW - HR-CS-MAS
PY - 2017
UR - http://www.sciencedirect.com/science/article/pii/S0584854717302537
DO - https://doi.org/10.1016/j.sab.2017.08.012
SN - 0584-8547
VL - 136
SP - 116
EP - 122
PB - Elsevier
CY - Amsterdam, The Netherlands
AN - OPUS4-42071
LA - eng
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - JOUR
A1 - Phukphatthanachai, Pranee
A1 - Panne, Ulrich
A1 - Jakubowski, Norbert
A1 - Vogl, Jochen
T1 - SI-traceable quantification of sulphur in copper metal and its alloys by ICP-IDMS
N2 - Previously applied methods for the quantification of sulphur in copper and other pure metals revealed a lack of SI-traceability and additionally showed inconsistent results, when different methods were compared.
Therefore, a reference procedure is required which allows SI-traceable values accompanied by a Sound uncertainty budget. In this study a procedure was developed for the quantification of total sulphur in copper at low concentration levels using inductively coupled plasma-isotope dilution mass spectrometry (ICP-IDMS). The major part of the copper matrix was separated by adding ammonia which forms a complex with the copper while releasing the sulphur followed by chromatographic separation using a weak cation resin. After that the sulphur fraction was further purified by chromatographic means using first an anion exchange method and second a chelating resin. The developed procedure shows high performance, especially concerning high efficiency in matrix removal (>99.999%) while keeping the recovery of sulphur above 80%. Procedure blanks are in the order of 3–53 ng resulting in LOD and LOQ values of 0.2 mg g1 and 0.54 mg g1, respectively. The procedure is sufficient to facilitate value assignment of the total sulphur mass fraction in reference materials. Additionally, relative measurement uncertainties were calculated to be below 1% and the measurement results were traceable to the SI. The procedure reported in this study is a new reference procedure for sulphur measurement in copper, being fit for two major purposes, certification of reference materials and assignment of reference values for inter-laboratory comparison.
KW - Traceability
KW - Measuremment uncertainty
KW - Isotope dilution mass spectrometry
KW - Reference measurements
PY - 2018
DO - https://doi.org/10.1039/c7ja00338b
SN - 0267-9477
SN - 1364-5544
VL - 33
IS - 1
SP - 90
EP - 101
PB - Royal Society of Chemistry
CY - Cambridge, UK
AN - OPUS4-43614
LA - eng
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - JOUR
A1 - Scharek, Vera M.
A1 - Pfeifer, Jens
A1 - Vogl, Jochen
A1 - Traub, Heike
A1 - Meermann, Björn
T1 - Tin fractionation analysis in sediment samples via on-line ID ETV/ICP-MS
N2 - We report a quantification approach for directly determining total tin and tin-based pollutants/species in sediments via electrothermal vaporization/inductively coupled plasma-mass spectrometry (ETV/ICP-MS) utilizing an on-line isotope dilution mass spectrometry (IDMS) approach. The method was developed and validated using an estuarine sediment reference material (BCR-277R), yielding a recovery of 106%. A relative standard deviation (RSD) of 14%, comparable to published data using a similar method, was obtained. A limit of quantification (LOQ) was estimated at 0.008 mg Sn kg−1 and sufficient for quantifying the total tin mass fraction of surface sediments along the tidal River Elbe course. Hereby, a decrease towards the river mouth, presumably due to dilution effects by less polluted marine sediment, was observed. Besides total tin, monitoring of organotin compounds (OTCs)/species is of interest in sediments due to their toxic effects on aquatic life. The method’s capability was extended by separating an OTC fraction in a sediment certified reference material (CRM) through the ETV temperature program. While spiking experiments with OTC standards confirmed the assignment, only a small fraction of the total certified OTC amount (3%), likely due to matrix effects, was recovered. However, applying the method to real-world samples, OTCs were detectable along the River Elbe course. By this, we demonstrated the potential of our method as a complementary fast-screening approach to species-specific analysis procedures.
KW - ETV
KW - Sn-Speciation
KW - Sediment
PY - 2025
UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-640137
DO - https://doi.org/10.1007/s00216-025-06064-y
SN - 1618-2642
SP - 1
EP - 10
PB - Springer Science and Business Media LLC
AN - OPUS4-64013
LA - eng
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - JOUR
A1 - Schannor, Mathias
A1 - Oelze, Marcus
A1 - Traub, Heike
A1 - He, Yubei
A1 - Schmidt, Robin
A1 - Heidemann, Luisa
A1 - Savic, Lynn Jeanette
A1 - Vogl, Jochen
A1 - Meermann, Björn
T1 - Advancing Biomarker Research: In Situ Cu Isotope Analysis in Liver Tumors by LA-MC-ICP-MS
N2 - Stable metal isotopes have received increasing attention as medical biomarkers due to their potential to detect changes in metal metabolism related to diseases. In particular, copper stable isotopes are a powerful tool to identify isotopic variation between tumors and healthy tissue, suggesting application in cancer diagnosis. However, potential mechanisms causing isotope fractionation, such as redox- or bond-forming reactions and interactions of metals during transmembrane import and export, are less well understood. Here, we established an in situ method using laser ablation-multicollector-inductively coupled plasma-mass spectrometry (LA-MC-ICP-MS) to advance our understanding of the underlying processes responsible for isotope fractionation between normal and diseased tissues. Gelatin-based bracketing standards and quality control reference materials, crucial for laser ablation analysis, were developed to allow correction for instrumentally induced isotope fractionation during LA-MC-ICP-MS analysis. Using such matrix-matched standards, the method achieved intermediate precisions for delta values of better than 0.15 ‰ (2 s) for inorganic reference materials and of better than 0.17 ‰ (2 s) for biological reference materials. The developed routine was tested on rabbit VX2 liver tumor samples, a model system resembling human hepatocellular carcinoma (HCC) used to study liver cancer. In situ Cu isotope compositions between healthy (𝛿65/63NIST976(Cu) = −1.5 ‰ to 0.2 ‰) and tumorous (𝛿65/63NIST976(Cu) = 0.0 ‰ to 1.3 ‰) liver tissue show distinct differences in their isotope ratios. The observed isotopic dichotomy is consistent with previous solution-based MC-ICP-MS work, showing enrichment of heavy 65Cu in cancer biopsies relative to healthy tissue.
KW - Biomarker
KW - Laser Ablation
KW - Reference Material
PY - 2025
UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-626865
DO - https://doi.org/10.1021/acs.analchem.4c05626
SN - 1520-6882
VL - 97
IS - 8
SP - 4425
EP - 4432
PB - American Chemical Society (ACS)
AN - OPUS4-62686
LA - eng
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - JOUR
A1 - Phukphatthanachai, Pranee
A1 - Vogl, Jochen
A1 - Traub, Heike
A1 - Jakubowski, Norbert
A1 - Panne, Ulrich
T1 - A new approach of using polyethylene frits for the quantification of sulphur in copper metals by isotope dilution LA-ICP-MS and comparison with conventional IDMS techniques
N2 - Polyethylene (PE) frits were used to quantify sulphur in copper and its alloys by isotope dilution combined with LA-ICP-MS as an alternative approach to conventional sample preparation: the copper samples were spiked, the spiked samples were dissolved, the resulting solutions were absorbed in the PE frits and finally the PE frits were analysed by LA-ICP-MS. A prerequisite for such a support material is a low sulphur blank and thus PE was selected for this purpose. The absorption efficiency of the PE frits was studied for varying sulphur amounts ranging from 2 mg S to 80 mg S showing that more than 99.5% of the loaded sulphur was absorbed by the frit. The so prepared PE frits were measured by LA-ICP-MS and yielded a good linearity (R2 ¼ 0.999) for the sulphur ion intensities corresponding to sulphur amounts up to 40 mg S; the associated sensitivity is approximately 3.4 x 10⁴ cps μg⁻¹ for ³²S. For the validation of the developed procedure the reference materials BAM-M376a, BAM-228 and BAM-227 were applied such that 2 μg S, 5 μg S and 11 μg S were absorbed in the PE frits, respectively. These samples were pre-quantified for the adsorbed sulphur amount by external calibration LA-ICP-MS yielding sulphur amounts of 0.9 μg, 5.1 μg and 8.5 μg (quantified for ³²S only), respectively. Relative Standard deviations of the isotope ratios were below 5% in average (n ¼ 3 lines) in all cases (except for the pure spike solution). These samples were then analysed by LA-ICP-IDMS and the measurement results were validated by comparing them with the results obtained by conventional ICP-IDMS. The obtained relative expanded measurement uncertainties ranged between 10% and 26%. Pearson's coefficient was used to express the correlation between both techniques; the obtained value was 0.999 demonstrating a strong correlation. Contrary to most published LA-ICP-IDMS procedures, the developed procedure enables SI-traceability for the measurement results. The metrological traceability to the SI for the sulphur mass fractions in copper was established by an unbroken chain of comparisons, each accompanied by an uncertainty budget. Thus, the measurement results are considered reliable, acceptable and comparable within the stated measurement uncertainty. The metrological traceability chain from the kg down to mass fraction in the samples obtained by LA-ICP-IDMS is presented as well.
KW - Laser ablation
KW - IDMS
KW - Traceability
KW - Uncertainty
KW - Purity
PY - 2018
DO - https://doi.org/10.1039/c8ja00116b
SN - 0267-9477
SN - 1364-5544
VL - 33
IS - 9
SP - 1506
EP - 1517
PB - Royal Society of Chemistry
CY - Cambridge
AN - OPUS4-45899
LA - eng
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - JOUR
A1 - Kazlagić, Anera
A1 - Stephan, D.
A1 - Ostermann, Markus
A1 - Possolo, A.
A1 - Vogl, Jochen
T1 - Fingerprinting Portland cements by means of 87Sr/86Sr and 143Nd/144Nd isotope ratios and geochemical profiles
N2 - This study uses conventional 87Sr/86Sr and 143Nd/144Nd isotope and interelement ratios of Ca, Sr, K, Mn, Mg and Ti as fingerprints for provenancing ordinary Portland cements (OPC). Herein, the first database of Sr and Nd isotope ratios investigated in OPCs, stemming from 29 cement plants located worldwide, was created. The results show that the Sr isotope ratios of OPCs are higher than those of seawater from the observed geological period. The spread of 143Nd/144Nd in OPCs is not as large as the spread for 87Sr/86Sr isotope ratios. However, the combination of both Sr and Nd isotope ratios provides the potential for distinguishing between cements of different production sites. Most of the OPCs investigated have measurable differences in their 87Sr/86Sr and 143Nd/144Nd isotope ratios, which can be employed as a valuable analytical fingerprinting tool. In the case of equivocal results, divisive hierarchical clustering was employed to help overcome this issue. The construction of geochemical profiles allowed the computing of suitably defined distances between cements and clustering them according to their chemical similarity. By applying this methodology, successful fingerprinting was achieved in 27 out of the 29 ordinary Portland cements that were analysed.
KW - Elemental fingerprints
KW - Geochemistry
KW - Portland cement
KW - Sr and Nd isotope analysis
KW - Statistical analysis
PY - 2023
DO - https://doi.org/10.1680/jadcr.23.00018
SN - 0951-7197
VL - 36
IS - 6
SP - 260
EP - 271
PB - Emerald Publishing Limited
AN - OPUS4-57979
LA - eng
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - JOUR
A1 - Phukphatthanachai, P.
A1 - Panne, Ulrich
A1 - Traub, Heike
A1 - Pfeifer, Jens
A1 - Vogl, Jochen
T1 - Quantification of sulphur in copper and copper alloys by GDMS and LA-ICP-MS, demonstrating metrological traceability to the international system of units
N2 - The quantification of the sulphur mass fraction in pure copper and copper alloys by GDMS and LA-ICP-MS revealed a lack of traceability mainly due to a lack of suitable certified reference materials for calibrating the instruments. Within this study GDMS and LA-ICP-MS were applied as routine analytical tools to quantify sulphur in copper samples by applying reference materials as calibrators, which were characterized for their sulphur mass fraction by IDMS beforehand. Different external calibration strategies were applied including a matrix cross type calibration. Both techniques with all calibration strategies were validated by using certified reference materials (others than those used for calibration) and good agreement with the reference values was achieved except for the matrix cross type calibration, for which the agreement was slightly worse. All measurement results were accompanied by an uncertainty statement. For GDMS, the relative expanded (k = 2) measurement uncertainty ranged from 3% to 7%, while for LA-ICP-MS it ranged from 11% to 33% when applying matrix-matched calibration in the sulphur mass fraction range between 25 mg kg-1 and 1300 mg kg-1. For cross-type calibration the relative expanded (k = 2) measurement uncertainty need to be increased to at least 12% for GDMS and to at least 54% for LA-ICP-MS to yield metrological compatibility with the reference values. The so obtained measurement results are traceable to the international system of units (SI) via IDMS reference values, which is clearly illustrated by the unbroken chain of calibrations in the metrological traceability scheme.
KW - Sulfur
KW - Copper
KW - GDMS
KW - LA-ICP-MS
KW - Uncertainty
KW - Traceability
KW - SI
PY - 2021
DO - https://doi.org/10.1039/d1ja00137j
SN - 0267-9477
VL - 36
IS - 11
SP - 2404
EP - 2414
PB - Royal Society of Chemistry
AN - OPUS4-53412
LA - eng
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - JOUR
A1 - Tukhmetova, Dariya
A1 - Lisec, Jan
A1 - Vogl, Jochen
A1 - Meermann, Björn
T1 - Data processing made easy: standalone tool for automated calculation of isotope ratio from transient signals – IsoCor
N2 - Despite numerous advantages offered by hyphenation of chromatography and electrokinetic separation methods with multicollector (MC) ICP-MS for isotope analysis, the main limitation of such systems is the decrease in precision and increase in uncertainty due to generation of short transient signals. To minimize this limitation, most authors compare several isotope ratio calculation methods and establish a multi-step data processing routine based on the precision and accuracy of the methods. However, to the best of our knowledge, there is no universal data processing tool available that incorporates all important steps of the treatment of the transient signals. Thus, we introduce a data processing application (App) IsoCor that facilitates automatic calculation of isotope ratios from transient signals and eases selection of the most suitable method. The IsoCor App performs baseline subtraction, peak detection, mass bias correction, isotope ratio calculation and delta calculation. The feasibility and reliability of the App was proven by reproducing the results from isotope analysis of three elements (neodymium, mercury and sulfur) measured on-line via hyphenated systems. The IsoCor App provides trackability of the results to ensure quality control of the analysis.
KW - Isotope ratio
KW - Transient signal
KW - MC-ICP-MS
KW - Data processing
KW - App
PY - 2022
UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-559068
DO - https://doi.org/10.1039/D2JA00208F
VL - 37
IS - 11
SP - 2401
EP - 2409
PB - Royal Society of Chemistry
AN - OPUS4-55906
LA - eng
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - JOUR
A1 - Matschat, Ralf
A1 - Richter, Silke
A1 - Vogl, Jochen
A1 - Kipphardt, Heinrich
T1 - On the way to SI traceable primary transfer standards for amount of substance measurements in inorganic chemical analysis
N2 - During its 25 years of existence, the Inorganic Analysis Working Group of the Consultative Committee for Amount of Substance: Metrology in Chemistry and Biology (CCQM IAWG) has achieved much in establishing comparability of measurement results. Impressive work has been done on comparison exercises related to real-world problems in fields such as ecology, food, or health. In more recent attempts, measurements and comparisons were focused on calibration solutions which are the basis of most inorganic chemical measurements. This contribution deals with the question of how to achieve full and transparent SI traceability for the values carried by such solutions. Within this framework, the use of classical primary methods (CPMs) is compared to the use of a primary difference method (PDM). PDM is a method with a dual character, namely a metrological method with a primary character, based on the bundling of many measurement methods for individual impurities, which lead to materials with certified content of the main component. As in classical methods, where small corrections for interferences are accepted, in PDM, many small corrections are bundled. In contrast to classical methods, the PDM is universally applicable to all elements in principle. Both approaches can be used to certify the purity (expressed as mass fraction of the main element) of a high-purity material. This is where the metrological need of National Metrology Institutes (NMIs) for analytical methods meet the challenges of analytical methods. In terms of methods, glow discharge mass spectrometry (GMDS) with sufficient uncertainties for sufficiently small impurity contents is particularly noteworthy for the certification of primary transfer standards (PTS), and isotope dilution mass spectrometry (IDMS), which particularly benefits from PTS (back-spikes) with small uncertainties, is particularly noteworthy for the application. The corresponding relative uncertainty which can be achieved using the PDM is very low (< 10−4). Acting as PTS, they represent the link between the material aspect of the primary calibration solutions and the immaterial world of the International System of Units (SI). The underlying concepts are discussed, the current status of implementation is summarised, and a roadmap of the necessary future activities in inorganic analytical chemistry is sketched. It has to be noted that smaller measurement uncertainties of the purity of high-purity materials not only have a positive effect on chemical measurements, but also trigger new developments and findings in other disciplines such as thermometry or materials science.
KW - Inorganic chemical analysis
KW - Primary transfer standards (PTSs)
KW - Traceability
KW - Classical primary measurement method (CPM)
KW - Primary difference measurement method (PDM)
KW - Metrology in chemistry
PY - 2023
UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-572743
DO - https://doi.org/10.1007/s00216-023-04660-4
SN - 1618-2642
SN - 1618-2650
VL - 415
SP - 3057
EP - 3071
PB - Springer
CY - Berlin
AN - OPUS4-57274
LA - eng
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - JOUR
A1 - Tukhmetova, Dariya
A1 - Lisec, Jan
A1 - Vogl, Jochen
A1 - Meermann, Björn
T1 - Development of an Online Isotope Dilution CE/ICP–MS Method for the Quantification of Sulfur in Biological Compounds
N2 - We report an analytical methodology for the quantification of sulfur in biological molecules via a speciesunspecific postcolumn isotope dilution (online ID) approach using capillary electrophoresis (CE) coupled online with inductively coupled plasma−mass spectrometry (online ID CE/ICP−MS).
The method was optimized using a mixture of standard compounds including sulfate, methionine, cysteine, cystine, and albumin, yielding compound recoveries between 98 and 105%. The quantity of sulfur is further converted to the quantity of the compounds owing to the prior knowledge of the sulfur content in the molecules. The limit of detection and limit of quantification of sulfur in the compounds were 1.3−2.6 and 4.1−8.4 mg L−1, respectively, with a correlation coefficient of 0.99 within the concentration range of sulfur of 5−100 mg L−1. The capability of the method was extended to quantify albumin in its native matrix (i.e., in serum) using experimentally prepared serum spiked with a pure albumin standard for validation. The relative expanded uncertainty of the method for the quantification of albumin was 6.7% (k = 2). Finally, we tested the applicability of the method on real samples by the analysis of albumin in bovine and human sera. For automated data assessment, a software application (IsoCor) which was developed by us in a previous work was developed further for handling of online ID data. The method has several improvements compared to previously published setups: (i) reduced adsorption of proteins onto the capillary wall owing to a special capillary-coating procedure, (ii) baseline separation of the compounds in less than 30 min via CE, (iii) quantification of several sulfur species within one run by means of the online setup, (iv) SI traceability of the quantification results through online ID, and (v) facilitated data processing of the transient signals using the IsoCor application. Our method can be used as an accurate approach for quantification of proteins and other biological molecules via sulfur analysis in complex matrices for various fields, such as environmental, biological, and pharmaceutical studies as well as clinical diagnosis.
Sulfur is an essential element in living organisms, where it plays important roles in various biological processes, such as protein synthesis, enzyme activity, and antioxidant defense. However, the biological effects of different sulfur species can vary widely, and imbalances in sulfur speciation have been observed in a range of diseases, including cancer, Alzheimer’s disease, and diabetes.1−3 The accurate quantification of sulfur and its species in biological samples requires sensitive and selective analytical techniques. In recent years, separation techniques coupled online with inductively coupled plasma−mass spectrometry (ICP−MS) have emerged as powerful online analytical tools complementary to molecular spectrometric methods for speciation analysis of biological compounds.
External calibration4−9 and isotope dilution (ID)10−15 are common calibration approaches applied for online quantification of sulfur species in complex samples. The ID analysis is advantageous over.
KW - Analytical Chemistry
KW - CE/MC-ICP-MS
KW - species-specific isotope information
PY - 2024
UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-594736
DO - https://doi.org/10.1021/acs.analchem.3c03553
SN - 0003-2700
SP - 1
EP - 8
PB - American Chemical Society (ACS)
AN - OPUS4-59473
LA - eng
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - JOUR
A1 - Vogl, Jochen
A1 - Kipphardt, Heinrich
A1 - Richter, Silke
A1 - Bremser, Wolfram
A1 - Arvizu Torres, M.
A1 - Lara Manzano, J.
A1 - Buzoianu, M.
A1 - Hill, S.
A1 - Petrov, P.
A1 - Goenaga-Infante, H.
A1 - Sargent, M.
A1 - Fisicaro, P.
A1 - Labarraque, G.
A1 - Zhou, T.
A1 - Turk, G. C.
A1 - Winchester, M.
A1 - Miura, T.
A1 - Methven, B.
A1 - Sturgeon, R.
A1 - Jährling, R.
A1 - Rienitz, O.
A1 - Mariassy, M.
A1 - Hankova, Z.
A1 - Sobina, E.
A1 - Krylov, A. I.
A1 - Kustikov, Y. A.
A1 - Smirnov, V. V.
T1 - Establishing comparability and compatibility in the purity assessment of high purity zinc as demonstrated by the CCQM-P149 intercomparison
N2 - For the first time, an international comparison was conducted on the determination of the purity of a high purity element. Participants were free to choose any analytical approach appropriate for their institute’s applications and services. The material tested was a high purity zinc, which had earlier been assessed for homogeneity and previously used in CCQM-K72 for the determination of six defined metallic impurities. Either a direct metal assay of the Zn mass fraction was undertaken by EDTA titrimetry, or an indirect approach was used wherein all impurities, or at least the major ones, were determined and their sum subtracted from ideal purity of 100 %, or 1 kg/kg. Impurity assessment techniques included glow discharge mass spectrometry, inductively coupled plasma mass spectrometry and carrier gas hot extraction/combustion analysis. Up to 91 elemental impurities covering metals, non-metals and semi-metals/metalloids were quantified. Due to the lack of internal experience or experimental capabilities, some participants contracted external laboratories for specific analytical tasks, mainly for the analysis of non-metals. The reported purity, expressed as zinc mass fraction in the high purity zinc material, showed excellent agreement for all participants, with a relative standard deviation of 0.011 %. The calculated reference value, w(Zn) = 0.999 873 kg/kg, was assigned an asymmetric combined uncertainty of + 0.000025 kg/kg and – 0.000028 kg/kg. Comparability amongst participating metrology institutes is thus demonstrated for the purity determination of high purity metals which have no particular difficulties with their decomposition / dissolution process when solution-based analytical methods are used, or which do not have specific difficulties when direct analysis approaches are used. Nevertheless, further development is required in terms of uncertainty assessment, quantification of non-metals and the determination of purity of less pure elements and/or for those elements suffering difficulties with the decomposition process.
KW - Purity assessment
KW - Direct metal assay
KW - Impurity assessment
KW - Non-metal analysis
KW - High-purity elements
KW - SI-traceability
PY - 2018
DO - https://doi.org/10.1088/1681-7575/aaa677
SN - 1681-7575
SN - 0026-1394
VL - 55
IS - 2
SP - 211
EP - 221
PB - Institute of Physics Publishing
CY - Bristol
AN - OPUS4-44257
LA - eng
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - CONF
A1 - Vogl, Jochen
T1 - Determination of total sulfur in a metal matrix by ICP-IDMS: Example Cu matrix
T2 - 14th International Symposium on Biological and Environmental Reference Materials (BERM 14)
CY - National Harbor, Maryland 20745 USA
DA - 2015-10-11
PY - 2015
AN - OPUS4-34482
LA - deu
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - JOUR
A1 - Herwig, Nadine
A1 - Stephan, Kristin
A1 - Panne, Ulrich
A1 - Pritzkow, Wolfgang
A1 - Vogl, Jochen
T1 - Multi-element screening in milk and feed by SF-ICP-MS
N2 - In this study, an analytical procedure for multi-element screening of 40 elements in milk and feed samples was developed. Three different digestion and two different calibration methods were tested for the best suitability. The analytical procedure for the quantification of minor and trace elements is based on sector field ICP-MS (SF-ICP-MS). The method validation revealed good agreement between the determined elemental mass fractions and the certified values of two milk and three feed reference materials. Milk samples of dairy cows at different feeding regimes were collected from two different farms. The results of our study showed significant differences of nine elemental mass fractions (Li, P, Mn, Co, Cu, Rb, Sr, Br, I) between milk from the two locations. Further, a correlation between the elemental mass fractions of milk and the ingested feed and water was observed.
KW - Multi-element screening
KW - SF-ICP-MS
KW - Dairy cows
KW - Milk
KW - Feed
KW - Water
PY - 2011
DO - https://doi.org/10.1016/j.foodchem.2010.07.050
SN - 0308-8146
VL - 124
IS - 3
SP - 1223
EP - 1230
PB - Elsevier Ltd.
CY - Amsterdam [u.a.] ; Jena
AN - OPUS4-22042
LA - eng
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - JOUR
A1 - Winckelmann, Alexander
A1 - Morcillo Garcia-Morato, Dalia
A1 - Richter, Silke
A1 - Recknagel, Sebastian
A1 - Riedel, Jens
A1 - Vogl, Jochen
A1 - Panne, Ulrich
A1 - Abad Andrade, Carlos Enrique
T1 - Determination of lithium in human serum by isotope dilution atomic absorption spectrometry
N2 - The therapeutic dose of lithium (Li) compounds, which are widely used for the treatment of psychiatric and hematologic disorders, is close to its toxic level; therefore, drug monitoring protocols are mandatory. Herein, we propose a fast, simple, and low-cost analytical procedure for the traceable determination of Li concentration in human serum, based on the monitoring of the Li isotope dilution through the partially resolved isotope shift in its electronic transition around 670.80 nm using a commercially available high-resolution continuum source graphite furnace atomic absorption spectrometer. With this technique, serum samples only require acidic digestion before analysis. The procedure requires three measurements—an enriched 6Li spike, a mixture of a certified standard solution and spike, and a mixture of the sample and spike with a nominal 7Li/6Li ratio of 0.82. Lanthanum has been used as an internal spectral standard for wavelength correction. The spectra are described as the linear superposition of the contributions of the respective isotopes, each consisting of a spin-orbit doublet, which can be expressed as Gaussian components with constant spectral position and width and different relative intensity, reflecting the isotope ratio in the sample. Both the spectral constants and the correlation between isotope ratio and relative band intensity have been experimentally obtained using commercially available materials enriched with Li isotopes. The Li characteristic mass (mc) obtained corresponds to 0.6 pg. The procedure has been validated using five human serum certified reference materials. The results are metrologically comparable and compatible to the certified values. The measurement uncertainties are comparable to those obtained by the more complex and expensive technique, isotope dilution mass spectrometry.
KW - Lithium
KW - Human serum
KW - Isotope dilution
KW - Atomic absorption spectrometry
KW - High-resolution continuum source graphite furnace atomic absorption spectrometry
PY - 2021
UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-532446
DO - https://doi.org/10.1007/s00216-021-03636-6
VL - 414
IS - 1
SP - 251
EP - 256
PB - Springer
CY - Berlin
AN - OPUS4-53244
LA - eng
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - JOUR
A1 - Winckelmann, Alexander
A1 - Nowak, S.
A1 - Richter, Silke
A1 - Recknagel, Sebastian
A1 - Riedel, Jens
A1 - Vogl, Jochen
A1 - Panne, Ulrich
A1 - Abad Andrade, Carlos Enrique
T1 - High-Resolution Atomic Absorption Spectrometry Combined With Machine Learning Data Processing for Isotope Amount Ratio Analysis of Lithium
N2 - An alternative method for lithium isotope amount ratio analysis based on a combination of high-resolution atomic absorption spectrometry and spectral data analysis by machine learning (ML) is proposed herein. It is based on the well-known isotope shift of approximately 15 pm for the electronic transition 22P←22S at around the wavelength of 670.8 nm, which can be measured by the state-of-the-art high-resolution continuum source graphite furnace atomic absorption spectrometry. For isotope amount ratio analysis, a scalable tree boosting ML algorithm (XGBoost) was employed and calibrated using a set of samples with 6Li isotope amount fractions, ranging from 0.06 to 0.99 mol mol–1, previously determined by a multicollector inductively coupled plasma mass spectrometer (MC-ICP-MS). The calibration ML model was validated with two certified reference materials (LSVEC and IRMM-016). The procedure was applied toward the isotope amount ratio determination of a set of stock chemicals (Li2CO3, LiNO3, LiCl, and LiOH) and a BAM candidate reference material NMC111 (LiNi1/3Mn1/3Co1/3O2), a Li-battery cathode material. The results of these determinations were compared with those obtained by MC-ICP-MS and found to be metrologically comparable and compatible. The residual bias was −1.8‰, and the precision obtained ranged from 1.9 to 6.2‰. This precision was sufficient to resolve naturally occurring variations, as demonstrated for samples ranging from approximately −3 to +15‰. To assess its suitability to technical applications, the NMC111 cathode candidate reference material was analyzed using high-resolution continuum source atomic absorption spectrometry with and without matrix purification. The results obtained were metrologically compatible with each other.
KW - Lithium
KW - Isotope
KW - Machine learning
KW - Algorithms
KW - Reference material
KW - AAS
KW - Atomic Absorption Spectrometry
PY - 2021
DO - https://doi.org/10.1021/acs.analchem.1c00206
SN - 1520-6882
VL - 93
IS - 29
SP - 10022
EP - 10030
PB - American Chemical Society
CY - Washington, DC, USA
AN - OPUS4-53028
LA - eng
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - JOUR
A1 - Morcillo, Dalia
A1 - Winckelmann, Alexander
A1 - Frick, Daniel A.
A1 - Jacobsen, Lars
A1 - Seger, Tino
A1 - Florek, Stefan
A1 - Richter, Silke
A1 - Vogl, Jochen
A1 - Recknagel, Sebastian
A1 - Panne, Ulrich
A1 - Abad Andrade, Carlos Enrique
T1 - Lithium isotope ratio analysis of geological samples using atomic absorption spectrometry with improved spectral resolution
N2 - This study introduces an improved spectrometric method with enhanced precision to determine isotope ratios in geological samples without chromatographic separation. Firstly, the improvement is achieved by increasing the spectral resolution of the spectrometer applied in well-known high-resolution continuum source atomic absorption spectrometry (HR-CS-AAS). The resulting resolving power and linear dispersion of the upgraded setup, which is denoted in the following as HR+CS-AAS, is well adapted to the line widths of the Li isotope components we investigated. Secondly, our proposed method combines optical absorption spectrometry with machine learning data analysis using an extreme gradient boosting algorithm (XGBoost). This method was applied to analyze certified geological reference materials with δLSVEC(7Li/6Li) (hereafter δ7Li) values ranging from −0.5 ‰ to 4.5 ‰. With a pixel related optical resolving power of λ/∆λ ≈ 780 000, we obtain precisions in δ7Li measurements from 1.0 ‰ to 2.5 ‰. The method is validated by comparing the results with multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS), confirming its metrological compatibility. This work presents a fast, robust, and reliable method for δ7Li measurement in geological samples.
KW - Isotope
KW - High-resolution continuum source atomic absorption spectroscopy
KW - Lithium
KW - Machine learning
KW - Echelle spectrometer
PY - 2024
UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-611807
DO - https://doi.org/10.1016/j.sab.2024.107013
VL - 220
SP - 1
EP - 5
PB - Elsevier BV
AN - OPUS4-61180
LA - eng
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - JOUR
A1 - Rosner, Martin
A1 - Vogl, Jochen
T1 - Bor: Isotopenverhältnisse und die Herkunft einer Probe
N2 - Die Industrie nutzt die Borisotopenanalytik in nukleartechnischen Anwendungen. Umwelt- und Geowissenschaften identifizieren anhand der Borisotopenverhältnisse Kontaminationsquellen und charakterisieren Mischungs- und Fraktionsprozesse. In der Lebensmittelanalytik dient der Parameter dazu, Herkunft und Anbauweise von Obst und Gemüse herauszufinden. Seit kurzem gibt es dafür ein validiertes Verfahren und erste Referenzdaten.
KW - Isotopenverhältnisse
KW - Herkunft
KW - TIMS
PY - 2012
SN - 1439-9598
SN - 1521-3854
VL - 60
IS - 2
SP - 147
EP - 149
PB - Wiley-VCH Verl.
CY - Weinheim
AN - OPUS4-25575
LA - deu
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - CONF
A1 - Vogl, Jochen
T1 - New Potential Hematite and Magnetite Reference Materials for Iron Isotope Analysis by Solution- and LA-MC-ICP-MS
N2 - Two potential reference materials HMIE-NP-B01 and MARK-NP-B01 for Iron isotope analysis. These two RMs will used later as calibrant the corroded material generated from MIC.
T2 - ANAKON 2025
CY - Leipzip, Germany
DA - 10.03.2025
KW - Fe isotope
KW - Fe-dominated minerals
KW - Laser ablation
KW - LA-MC-ICP-MS
PY - 2025
AN - OPUS4-62829
LA - eng
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - CONF
A1 - Vogl, Jochen
T1 - CCQM-P149 Purity determination of zinc to be used as primary standard for zinc determination
T2 - CCQM IAWG Meeting
CY - Pretoria, South Africa
DA - 2013-11-05
PY - 2013
AN - OPUS4-29297
LA - deu
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - CONF
A1 - Vogl, Jochen
T1 - CCQM-K72 & P107.1 - Purity of zinc with respect to six metallic analytes
T2 - CCQM IAWG Meeting
CY - Pretoria, South Africa
DA - 2013-11-05
PY - 2013
AN - OPUS4-29298
LA - deu
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - CONF
A1 - Vogl, Jochen
T1 - CCQM-K72 & P107.1 - Purity of zinc with respect to six metallic analytes
T2 - CCQM IAWG Meeting
CY - Paris, France
DA - 2013-04-15
PY - 2013
AN - OPUS4-30776
LA - deu
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - CONF
A1 - Vogl, Jochen
T1 - CCQM-P149 - Purity determination of zinc to be used as primary standard for zinc determination
T2 - CCQM IAWG Meeting
CY - Paris, France
DA - 2014-04-07
PY - 2014
AN - OPUS4-30525
LA - deu
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - CONF
A1 - Vogl, Jochen
T1 - CCQM-K72 & P107.1 - Purity of zinc with respect to six metallic analytes
T2 - CCQM IAWG Meeting
CY - Paris, France
DA - 2014-04-07
PY - 2014
AN - OPUS4-30526
LA - deu
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - CONF
A1 - Vogl, Jochen
T1 - Preparation and Characterization of an SI-traceable Mg isotope Reference Material
T2 - Primary Reference Materials and Solutions Stakeholder Workshop and Training Course
CY - Berlin, Gemany
DA - 2015-06-22
PY - 2015
N1 - Geburtsname von Mieller, Björn: Brandt, B. - Birth name of Mieller, Björn: Brandt, B.
AN - OPUS4-33601
LA - deu
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - CONF
A1 - Vogl, Jochen
T1 - Absolute Mg isotope ratio measurements
T2 - Final Project meeting SIB09 ELEMENTS
CY - Berlin, Germany
DA - 2015-06-23
PY - 2015
N1 - Geburtsname von Mieller, Björn: Brandt, B. - Birth name of Mieller, Björn: Brandt, B.
AN - OPUS4-33600
LA - deu
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - CONF
A1 - Vogl, Jochen
T1 - Certification of an isotope reference material (IRM) for magnesium: Determination of SI traceable isotope ratios
T2 - 14th International Symposium on Biological and Environmental Reference Materials (BERM 14)
CY - National Harbor, Maryland 20745 USA
DA - 2015-10-11
PY - 2015
N1 - Geburtsname von Mieller, Björn: Brandt, B. - Birth name of Mieller, Björn: Brandt, B.
AN - OPUS4-34483
LA - deu
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - CONF
A1 - Vogl, Jochen
T1 - Calibration of Mg isotope amount ratios and delta values
N2 - In the past, δ26/24Mg measurements were referenced to NIST SRM 980, the initial zero of the δ26/24Mg scale. With the development of MC-ICPMS, the detection of small but measurable isotopic differences in different chips of SRM 980 became apparent. To solve this problem a suite of magnesium isotope reference materials, ERM-AE143, -AE144 and -AE145, has been certified in a first study by applying an ab initio calibration for absolute Mg isotope ratios without any a priori assumptions, a procedure which fulfils all requirements of a primary method of measurement. We could achieve for the first time measurement uncertainties for isotope amount ratios close to the typical precision of magnesium delta values, δ26/24Mg, which are at the 0.1 ‰ level (2SD). In addition, it was demonstrated that commonly used fractionation laws are invalid for correcting Mg isotope ratios in multi-collector ICPMS as they result in a bias which is not covered by its associated uncertainty. Depending on their type, fractionation laws create a bias up to several per mil, with the exponential law showing the smallest bias between 0.1 ‰ to 0.7 ‰.
With these isotope reference materials, it is possible to establish SI-traceability for magnesium delta measurements. To realize this, we organized a second study within which five expert laboratories participated to cross-calibrate all available magnesium isotope standards, which are NIST SRM 980, IRMM-009, ERM-AE143, ERM-AE144, ERM-AE145 and the standards DSM3 and Cambridge-1. The mean δ26/24Mg values for the individual iRMs, calculated from the laboratory means show 2 SD reproducibilities varying between 0.025 and 0.093 ‰. Propagated measurement uncertainties suggest a standard uncertainty of about 0.1‰ for δ26/24Mg determinations (2SD). Thus, SI traceability for magnesium isotope amount ratios and delta values is demonstrated to be established.
T2 - 53rd annual conference of the DGMS including 27th ICP-MS User's Meeting
CY - Münster, Germany
DA - 01.03.2020
KW - Isotope ratio
KW - Delta value
KW - Metrology
KW - Magnesium
KW - Magnesium isotope ratios
PY - 2020
N1 - Geburtsname von Mieller, Björn: Brandt, B. - Birth name of Mieller, Björn: Brandt, B.
AN - OPUS4-50549
LA - eng
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -
TY - JOUR
A1 - Yu, Jialu
A1 - Oelze, Marcus
A1 - Schannor, Mathias
A1 - Nordstad, Simon
A1 - Vogl, Jochen
T1 - New Potential Haematite and Magnetite Reference Materials for Iron Isotope Measurements by Solution Nebulisation MC ‐ ICP ‐ MS and by In Situ ns ‐ LA ‐ MC ‐ ICP ‐ MS
N2 - Iron isotope ratios of haematite (Fe2O3) and magnetite (Fe3O4) provide insights into geochemical, environmental and planetary processes. In most studies, Fe isotope measurements are commonly performed using solution nebulisation multi-collector inductively coupled plasma-mass spectrometry (SN-MC-ICP-MS). Nanosecond laser ablation multi-collector inductively coupled plasma-mass spectrometry (ns-LA-MC-ICP-MS) requires minimal sample preparation, and provides spatially resolved variation of iron isotopes at micro-scale. However, homogeneous and matrix-matched haematite/magnetite reference materials are lacking for precise in situ isotopic measurement. The iron isotope ratios of two potential reference materials resembling natural haematite (HMIE-NP-B01) and natural magnetite (MAKP-NP-B01) were characterised. Size fractions between 5–63 μm of the powdered Fe oxides were milled to nanoparticles, freeze-dried, homogenised, and pressed into pellets. The materials were then evaluated using SN-MC-ICP-MS and LA-MC-ICP-MS. Sample powders of the two materials were measured by SN-MC-ICPMS after sample digestion and column separation and pressed pellets were analysed directly via ns-LA-MC-ICP-MS. In both cases iron isotope delta values are reported relative to the certified reference material IRMM-014, used as the bracketing standard (calibrator). The solution measurements yielded δ56Fe values of -0.25 ± 0.08‰ (N = 13, 2s) for HMIE-NP-B01, and -0.05 ± 0.09‰ (N = 12, 2s) for MAKP-NP-B01, considered as the preferred Fe isotope delta values. In situ isotopic analysis via ns-LA-MC-ICP-MS yielded δ56Fe values of -0.28 ± 0.28‰ (N = 19, 2s) for HMIE-NP-B01 and -0.12 ± 0.24‰ (N = 22, 2s) for MAKP-NP-B01, consistent with the solution Fe isotope data. The homogeneity of Fe isotopes of the pellets was evaluated by ns-LA-MC-ICP-MS analyses of three different positions to further confirm that both materials are isotopically homogeneous. Both materials can be considered as potential quality control and bracketing reference materials for Fe isotopic measurements by in situ ns-LA-MC-ICP-MS analysis.
KW - Laser ablation
KW - Fe isotope
KW - Fe-oxides
PY - 2026
UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-654755
DO - https://doi.org/10.1111/ggr.70037
SN - 1639-4488
SP - 1
EP - 12
PB - John Wiley & Sons Ltd.
AN - OPUS4-65475
LA - eng
AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany
ER -