TY - JOUR A1 - Lisec, Jan A1 - Kobelt, D. A1 - Walther, W. A1 - Mokrizkij, M. A1 - Grötzinger, C. A1 - Jaeger, Carsten A1 - Baum, K. A1 - Simon, M. A1 - Wolf, J. A1 - Beindorf, N. A1 - Brenner, W. A1 - Stein, U. T1 - Systematic Identification of MACC1-Driven Metabolic Networks in Colorectal Cancer N2 - MACC1 is a prognostic and predictive metastasis biomarker for more than 20 solid Cancer entities. However, its role in cancer metabolism is not sufficiently explored. Here, we report on how MACC1 impacts the use of glucose, glutamine, lactate, pyruvate and fatty acids and show the comprehensive analysis of MACC1-driven metabolic networks. We analyzed concentrationdependent changes in nutrient use, nutrient depletion, metabolic tracing employing 13C-labeled substrates, and in vivo studies. We found that MACC1 permits numerous effects on cancer metabolism. Most of those effects increased nutrient uptake. Furthermore, MACC1 alters metabolic pathways by affecting metabolite production or turnover from metabolic substrates. MACC1 supports use of glucose, glutamine and pyruvate via their increased depletion or altered distribution within metabolic pathways. In summary, we demonstrate that MACC1 is an important regulator of metabolism in cancer cells. KW - Mass Spectroscopy KW - Metabolomics KW - Cancer PY - 2021 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-533526 DO - https://doi.org/10.3390/cancers13050978 VL - 13 IS - 5 SP - 1 EP - 22 PB - MDPI Journal Cancers AN - OPUS4-53352 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Philipp, B. A1 - Wagenknecht, W. A1 - Nehls, Irene A1 - Klemm, D. A1 - Stein, A. A1 - Heinze, Th. T1 - Regioselective derivatization of cellulose-routes of synthesis, effects on properties and areas of application KW - Zellulose KW - Routing KW - Regioselektivität PY - 1996 SN - 0032-3918 SN - 0370-050X VL - 21 SP - 115 EP - 161 PB - Gordon and Breach CY - New York, NY AN - OPUS4-701 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Bierett, Georg A1 - Stein, W. T1 - Prüfung der Schweißempfindlichkeit des Baustahles St. 52 an Biegeproben mit Längsraupen PY - 1940 IS - 26 SP - 418 PB - Springer CY - Berlin AN - OPUS4-17030 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Bierett, Georg A1 - Stein, W. T1 - Über Zugversuche an Stäben mit Längsnähten als Eignungsnachweis für Stahl und Schweißung PY - 1940 IS - 26 SP - 418 EP - 419 PB - Springer CY - Berlin AN - OPUS4-17031 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Bierett, Georg A1 - Stein, W. T1 - Prüfung der Schweißempfindlichkeit des Baustahls St 52 an Biegeproben mit Längsraupen PY - 1939 SN - 0372-7076 IS - 2 SP - 71 EP - 74 PB - Springer CY - Berlin AN - OPUS4-17291 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -