TY - JOUR A1 - Pires, A. A1 - Almeida, Ângela A1 - Calisto, V. A1 - Schneider, Rudolf A1 - Esteves, V. I. A1 - Wrona, F. J. A1 - Soares, A. M. V. M. A1 - Figueira, E. A1 - Freitas, R. T1 - Hediste diversicolor as bioindicator of pharmaceutical pollution: Results from single and combined exposure to carbamazepine and caffeine N2 - Several environmental stressors have been identified as key and/or emerging drivers of habitat change that could significantly influence marine near-shore ecosystems. These include increasing discharges of pharmaceutical contaminants into the aquatic coastal systems. Pharmaceutical drugs are often detected in aquatic environments but still information on their toxicity impacts on inhabiting species is scarce, especially when acting in combination. Furthermore, almost no information is available on the impacts of pharmaceuticals in polychaetes, often the most abundant taxon in benthic communities and commonly used as indicator species of environmental conditions. Therefore, the present study aimed to evaluate the biochemical alterations induced in the polychaete Hediste diversicolor, from a low contaminated area at the Ria de Aveiro lagoon (Portugal), by the antiepileptic drug carbamazepine (0.0 - control, 0.3, 3.0, 6.0 and 9.0 μg/L) and the stimulant caffeine (0.0 - control, 0.5, 3.0, and 18.0 μg/L), acting alone and in combination (0.3 CBZ + 0.5 CAF and 6.0 CBZ + 3.0 CAF). Glutathione Stransferases (GSTs), superoxide dismutase (SOD) and catalase (CAT) activities was determined in Hediste diversicolor from each condition. Lipid peroxidation (LPO), glutathione reduced and oxidized (GSH and GSSG), glycogen and electron transport system (ETS) were also measured. The results obtained clearly revealed that both drugs induced oxidative stress in H. diversicolor, shown by the increase on LPO levels and decrease on total glutathione and GSH/GSSG ratio with the increase of exposure concentrations. Furthermore, the present findings demonstrated that polychaetes biotransformation capacity as well as antioxidant defense mechanisms were not sufficiently efficient to fight against the excess of reactive oxygen species (ROS) leading to LPO when organisms were exposed to both drugs. Our results also demonstrated that polychaetes tended to decrease the activity of ETSwhen exposed to drugs, avoiding energy expenditurewhich may prevent them fromgreater damages. The present study further revealed that the impacts induced by the combination of both drugswere similar to those obtained at the highest drugs concentrations acting alone. KW - Invertebrates KW - Pharmaceuticals KW - Oxidative stress biomarkers KW - Energy reserves PY - 2016 DO - https://doi.org/10.1016/j.cbpc.2016.06.003 VL - 2016 IS - 188 SP - 30 EP - 38 PB - Elsevier Inc. AN - OPUS4-38509 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Tamschick, S. A1 - Rozenblut-Kościsty, B. A1 - Ogielska, M. A1 - Lehmann, Andreas A1 - Lymberakis, P. A1 - Hoffmann, F. A1 - Lutz, I. A1 - Schneider, Rudolf A1 - Kloas, W. A1 - Stöck, M. T1 - Impaired gonadal and somatic development corroborate vulnerability differences to the synthetic estrogen ethinylestradiol among deeply diverged anuran lineages N2 - Amphibians are undergoing a global decline. One poorly investigated reason could be the pollution of aquatic habitats by endocrine disrupting compounds (EDCs). We tested the susceptibility to the synthetically stabilized estrogen 17α-ethinylestradiol (EE2) in three deeply diverged anuran species, differing in sex determination systems, types of gonadogenesis and larval ecologies. To understand whether data from the amphibian model Xenopus laevis (Pipidae) are analogous and applicable to only distantly related non-model amphibians, tadpoles of X. laevis, Hyla arborea (Hylidae) and Bufo viridis (Bufonidae) were simultaneously exposed to 50, 500 and 5000 ng/L EE2 from hatching until completion of metamorphosis, using a flow-through-system under identical experimental conditions. Comparing molecularly established genetic with histologically assessed phenotypic sex in all species, we have recently shown that EE2 provoked numerous genetic-male-to-phenotypic-female sex reversals and mixed sex individuals, confirming overall its expected feminizing effect. In the present study, we focus on the influence of EE2 on gonadal and somatic development. Anatomy and histology revealed several species-specific effects. In both non-model species, H. arborea and B. viridis, high numbers of anatomically impaired gonads were observed. In H. arborea, exposed to 5000 ng/L EE2, numerous underdeveloped gonads were detected. Whereas EE2 did not alter snout-to-vent length and body weight of X. laevis metamorphs, H. arborea showed a treatment-dependent decrease, while B. viridis exhibited an increase in body weight and snout-to-vent length. Apart from a concentration-dependent occurrence of yellowish skin color in several H. arborea, no organ-specific effects were detected. Since EE2 ubiquitously occurs in many aquatic ecosystems and affects sexual and somatic development, among EDCs, it may indeed contribute to amphibian decline. The inter-species variation in developmental EE2-effects corroborates species-specific vulnerability differences towards EDCs between deeply diverged amphibian groups KW - Endocrine disruption KW - Ethinylestradiol KW - Mass spectrometry PY - 2016 DO - https://doi.org/10.1016/j.aquatox.2016.07.001 SN - 0166-445X SN - 1879-1514 VL - 177 SP - 503 EP - 514 PB - Elsevier AN - OPUS4-37633 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Schneider, Rudolf A1 - Teixiera, M. A1 - Almeida, Ângela A1 - Calisto, V. A1 - Esteves, V. I. A1 - Wrona, F. J. A1 - Soares, A. M. V. M. A1 - Figueira, E. A1 - Freitas, R. T1 - Toxic effects of the antihistamine cetirizine in mussel Mytilus galloprovincialis N2 - Recent studies have become increasingly focused on the assessment of pharmaceuticals occurrence in aquatic ecosystems, however the potential toxicity to non-target organisms is still largely unknown. The antihistamine cetirizine is a commonly used pharmaceutical, already detected in surface waters of marine aquatic systems worldwide. In the present study Mytilus galloprovincialis mussels were exposed to a range of cetirizine concentrations (0.3, 3.0, 6.0 and 12.0 mu/L), resembling moderate to highly contaminated areas, over 28 days. The responses of different biochemical markers were evaluated in mussels whole soft tissue, and included energy-related parameters (glycogen content, GLY; protein content, PROT; electron transport system activity, ETS), and oxidative stress markers (superoxide dismutase activity, SOD; catalase activity, CAT; glutathione S-transferases activity, GSTs; lipid peroxidation levels, LPO; reduced (GSH) and oxidized (GSSG) glutathione content). The results obtained demonstrated that with the increase of exposure concentrations mussels tended to increase their energy reserves and maintain their metabolic potential, which was significantly higher only at the highest concentration. Our findings clearly revealed that cetirizine inhibited the activity of GSTs and although induced the activity of antioxidant enzymes (SOD and CAT) mussels were not able to prevent cellular damages observed through the increase of LPO associated to the increase of exposure concentrations. Thus, this study confirmed that cetirizine induces toxic effects in Mytilus galloprovincialis, which, considering their trophic relevance, wide use as bioindicator and wide spatial distribution of this species, can result in ecological and economic negative impacts at a large scale. KW - Bivalves KW - Biomarkers KW - Oxidative Stress PY - 2017 DO - https://doi.org/10.1016/j.watres.2017.02.032 SN - 0043-1354 VL - 114 SP - 316 EP - 326 AN - OPUS4-43302 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Schneider, Rudolf A1 - Oliveira, P. A1 - Almeida, Ângela A1 - Calisto, V. A1 - Esteves, V. I. A1 - Wrona, F. J. A1 - Soares, A. M. V. M. A1 - Figueira, E. A1 - Freitas, R. T1 - Physiological and biochemical alterations induced in the mussel Mytilus galloprovincialis after short and long-term exposure to carbamazepine N2 - The bivalve Mytilus galloprovincialis collected in the Ria de Aveiro, was selected to evaluate the acute and chronic effects of carbamazepine (CBZ) at environmentally relevant concentrations. CBZ is an antiepileptic drug widely found in the aquatic environment with toxic effects to inhabiting organisms. However, few studies evaluated the acute and chronic toxicity of this drug. The experiment was performed 'by exposing mussels to 0.0, 0.3, 3.0, 6.0 and 9.0 CBZ mu g/L, for 96 h and 28 days. To assess the toxicity of the drug, a battery of biomarkers related to mussels general physiological health status and oxidative stress was applied. CBZ was quantified in mussel tissues by an Enzyme-Linked Immunosorbent Assay (ELISA). The results obtained show that CBZ did not induce oxidative stress. However, our findings,demonstrated that the drug was taken up by mussels even though presenting low bioconcentration factor (BCF) values (up to 2.2). Furthermore, our results demonstrated that after a chronic exposure the physiological parameters, namely the condition and gonadosomatic indices, were negatively affected which may impair organisms' reproductive capacity with consequences to population sustainability. KW - Pharmaceuticals KW - Bivalves KW - Oxidative Stress PY - 2017 DO - https://doi.org/10.1016/j.watres.2017.03.052 SN - 0043-1354 VL - 117 SP - 102 EP - 114 PB - Elsevier Ltd. AN - OPUS4-43304 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Schneider, Rudolf A1 - Fernandez, L. A1 - Borzecka, W. A1 - Lin, Z. A1 - Huvaere, K. A1 - Esteves, V. I. A1 - Cunha, A. A1 - Tome, J. P. C. T1 - Nanomagnet-photosensitizer hybrid materials for the degradation of 17 beta-estradiol in batch and flow modes N2 - The preparation of porphyrins and phthalocyanines covalently attached onto nanostructured magnetic supports consisting of magnetite nanoparticles coated with an amorphous silica shell is reported. The easy recovery of these heterogeneous photocatalysts, just by applying an external magnetic field, allows their reuse in multiple treatment cycles. The photocatalytic activity of the non-immobilized photosensitizers and the obtained hybrid materials was evaluated in the degradation of 17 beta-estradiol, as a model organic pollutant present in water, using batch and flow mode treatment systems, assisted by visible light radiation (4 mW cm(-2)). The flow mode system potentiated the photocatalytic capacity of these novel hybrid materials. In order to improve the process, further studies based on different photocatalyst concentration and pH conditions were performed. Reuse capacity of these materials was investigated upon three photocatalytic cycles. KW - Photodegradation KW - 17 beta-Estradiol KW - Porphyrin PY - 2017 DO - https://doi.org/10.1016/j.dyepig.2017.04.010 SN - 0143-7208 VL - 142 SP - 535 EP - 543 PB - Elsevier Ltd. AN - OPUS4-43308 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Schneider, Rudolf A1 - Almeida, Ângela A1 - Calisto, V. A1 - Esteves, V. I. A1 - Soares, A. M. V. M. A1 - Figueira, E. A1 - Freitas, R. T1 - Ecotoxicity of the antihistaminic drug cetirizine to Ruditapes philippinarum clams N2 - Cetirizine (CTZ) is an antihistaminic drug present in the aquatic environment, with limited information on its toxicity to organisms inhabiting this system. This study intended to evaluate the effects of CTZ on oxidative stress and energy metabolism biomarkers in the edible clam Ruditapes philippinarum after a 28 days exposure to environmentally relevant CTZ concentrations (0.0, 0.3, 3.0, 6.0 and 12.0 mu g/L). The results obtained showed that CTZ was accumulated by clams reaching maximum concentrations (up to similar to 22 ng/g FW) at the highest CTZ exposure concentrations (6.0 and 12.0 mu g/L). The bioconcentration factor (average maximum values of similar to 5) decreased at 12.0 mu g/L reflecting a reduction in clams uptake or increase of excretion capacity at this condition. The present study revealed that, in general, clams decreased the metabolic potential after exposure to CTZ (decrease in electron transport system activity), a response that led to the maintenance of glycogen content in organisms exposed to CTZ in comparison to control values. Our findings also showed that, CTZ did not exert significant levels of oxidative injury to clams. However, comparing the control with the highest exposure concentrations (6.0 and 12.0 mu g/L) a significant increase of the antioxidant enzyme superoxide activity (similar to 53 and similar to 44%) was observed in clams exposed to CTZ. Moreover, a tendency to increase lipid peroxidation (similar to 14 and similar to 9%) and carbonyl groups on proteins (similar to 11 and similar to 3%) was observed in clams exposed to CTZ (6.0 and 12.0 mu g/L) compared to control condition. Overall the present study suggests that toxic impacts may be induced in R. philippinarum if exposed for longer periods or higher CTZ concentrations. KW - Antihistamines KW - Clams KW - Biomarkers PY - 2017 DO - https://doi.org/10.1016/j.scitotenv.2017.05.149 SN - 0048-9697 VL - 601 SP - 793 EP - 801 PB - Elsevier B.V. AN - OPUS4-43311 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Hakim, I. A1 - Schumacher, David A1 - Sundar, V. A1 - Donaldson, S. A1 - Creuz, A. A1 - Schneider, R. A1 - Keller, J. A1 - Browning, C. A1 - May, D. A1 - Abo Ras, M. A1 - Meyendorf, N. ED - Chimenti, D. E. ED - Bond, L. J. T1 - Volume imaging NDE and serial sectioning of carbon fiber composites N2 - A composite material is a combination of two or more materials with very different mechanical, thermal and electrical properties. The various forms of composite materials, due to their high material properties, are widely used as structural materials in the aviation, space, marine, automobile, and sports industries. However, some defects like voids, delamination, or inhomogeneous fiber distribution that form during the fabricating processes of composites can seriously affect the mechanical properties of the composite material. In this study, several imaging NDE techniques such as: thermography, high frequency eddy current, ultrasonic, x-ray radiography, x-ray laminography, and high resolution x-ray CT were conducted to characterize the microstructure of carbon fiber composites. Then, a 3D analysis was implemented by the destructive technique of serial sectioning for the same sample tested by the NDE methods. To better analyze the results of this work and extract a clear volume image for all features and defects contained in the composite material, an intensive comparison was conducted among hundreds of 3D-NDE and multi serial sections’ scan images showing the microstructure variation. T2 - 44TH ANNUAL REVIEW OF PROGRESS IN QUANTITATIVE NONDESTRUCTIVE EVALUATION CY - Provo, Utah, USA DA - 16.07.2017 KW - Carbon fiber reinforced polymers KW - Non-destructive testing KW - Thermography KW - Eddy current KW - Ultrasound KW - X-ray radiography KW - X-ray laminography KW - X-ray computed tomography KW - Serial sectioning PY - 2018 DO - https://doi.org/10.1063/1.5031590 VL - 1949 SP - 120003-1 EP - 120003-10 PB - AIP Publishing AN - OPUS4-45173 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Almeida, Â. A1 - Freitas, R. A1 - Calisto, V. A1 - Esteves, V. I. A1 - Schneider, Rudolf A1 - Soares, A. M. V. M. A1 - Figueira, E. A1 - Campos, B. A1 - Barata, C. T1 - Effects of carbamazepine and cetirizine under an ocean acidification scenario on the biochemical and transcriptome responses of the clam Ruditapes philippinarum N2 - Several works evaluated the toxicity of pharmaceutical drugs and climate related changes in invertebrates but few explored the combined effects of both stressors, namely considering their mode of action (MoA). Carbamazepine (CBZ) and cetirizine (CTZ) are pharmaceutical drugs detected in the environment and the toxicity derived from the combined effects of these drugs with ocean acidification (OA) is poorly explored. Thus, the present study investigated the biochemical parameters related to an oxidative stress response and the transcription of genes related to the MoA of CBZ (1.0 mg/L) and CTZ (0.6 mg/L) in the clam Ruditapes philippinarum chronically exposed (28 days) to control (7.8) and low (7.5) pH conditions. The results obtained showed that despite the clams accumulated both drugs, at low pH the clams exposed to CTZ decreased drug concentration and BCF values (CTZ uptake: 2.0 ± 0.5 ng/g fresh weight; BCF: 3.8 ± 0.9) in comparison with clams exposed to control pH (CTZ uptake: 2.9 ± 0.3 ng/g fresh weight; BCF: 5.5 ± 0.6). No oxidative stress was induced by the exposure to CBZ or CTZ at each pH level, but the transcription of several genes related with the MoA (neurotransmission, immunity and biomineralization) was altered by low pH, drug exposure and the combination of both stressors. At both pH conditions, CBZ increased the transcription of GABA receptor gene (neurotransmission) and CTZ led to a decrease of Perlucin gene (biomineralization) transcription. The transcription of MyD88 gene (immunity) decreased at low pH (7.5) combined with drug exposure (CBZ or CTZ). Thus, it was highlighted that the interaction of drug exposure and low pH conditions can change bivalves’ sensitivity to drugs or alter drugs toxicity. KW - Carbamazepine KW - Biomarker KW - ELISA KW - Biochemische Parameter PY - 2018 DO - https://doi.org/10.1016/j.envpol.2017.12.121 SN - 0269-7491 VL - 235 SP - 857 EP - 868 PB - Elsevier Ltd. CY - Amsterdam, NL AN - OPUS4-44739 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Fernández, L. A1 - Lin, Z. A1 - Schneider, Rudolf A1 - Esteves, V. I. A1 - Cunha, Â. A1 - Tomé, J. P. C. T1 - Antimicrobial Photodynamic Activity of Cationic Nanoparticles Decorated with Glycosylated Photosensitizers for Water Disinfection N2 - The antimicrobial photodynamic approach has been demonstrated as an efficient and sustainable process for the eradication of microbial pathogens. In this work, silica-coated Magnetite nanoparticles (NPs) were used as carriers of glycosylated porphyrins and phthalocyanines. Their subsequent cationization resulted in the production of stable antimicrobial photosensitizing materials, effective against E. coli. Suspensions of the photocatalysts in water present bimodal size distributions formed by big clusters and small NPs with hydrodynamic diameters between 8 and 38 nm. The presence of small NPs in the suspensions is related to an effective photodynamic inactivation (PDI) of E. coli cells. Glycosylation of the PS showed a positive effect on the PDI performance, which could be related to a higher accumulation of the photocatalyst over the bacterial cell membrane. In addition, these biocidal agents proved to be photostable and their photoactive performance decreased only between 23% and 28% upon 5 PDI cycles, mostly because of the loss of material between cycles, which makes them promising materials for water disinfection purposes. KW - Photodynamische Inaktivierung KW - E. coli KW - Photokatalyse KW - Bakterien KW - Nanopartikel KW - Photosensibilisator KW - Porphyrin KW - Phthalocyanin PY - 2018 DO - https://doi.org/10.1002/cptc.201700169 SN - 2367-0932 VL - 2 IS - 7 SP - 596 EP - 605 PB - Wiley VHC CY - Weinheim AN - OPUS4-45684 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Hille, Falk A1 - Herrmann, Ralf A1 - Schneider, Ronald A1 - Pitters, S. A1 - Wedel, F. A1 - Hindersmann, I. T1 - Developing a guideline for structural health monitoring of road bridges in Germany N2 - In recent years, Structural Health Monitoring (SHM) has become a useful and increasingly widely used tool for supporting lifetime extensions of existing bridges with known structural deficiencies or indications of potentially critical damages or damage processes. At the same time, methods and tools are emerging, which enable monitoring-informed predictive maintenance of new and existing bridges based on digital twins. The monitoring process – starting from the definition of monitoring actions and ending with decisions based on monitoring outcomes – is complex and requires expertise in structural engineering, operation and maintenance of bridges, metrology, and data analytics. To support German road authorities, engineering consultancies, building contractors and other stakeholders of the bridge management, the Federal Highway Research Institute (BASt) has initiated the development of a new guideline for applying SHM as part of the management of road bridges. The guideline will present various use cases and for each identified use case, it will propose a proven monitoring scheme. In addition, the guideline will provide guidance on assessing the benefits of SHM as well as a common approach to managing monitoring data as a systematic basis for integrating monitoring data in the bridge management. This contribution discusses the motivation, objectives, and scope of the guideline, describes its use case centric structure and outlines the proposed data management. T2 - IABMAS 2024 CY - Kopenhagen, Danmark DA - 24.06.2024 KW - Guideline KW - Structural health monitoring KW - Road bridges KW - Infrastructure PY - 2024 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-613947 SN - 978-1-032-77040-6 DO - https://doi.org/10.1201/9781003483755-236 SP - 2009 EP - 2017 PB - CRC Press AN - OPUS4-61394 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Wedel, F. A1 - Pitters, S. A1 - Herrmann, Ralf A1 - Schneider, Ronald A1 - Hille, Falk A1 - Hindersmann, I. T1 - Guideline for the strategic application of monitoring of road bridges in Germany N2 - Engineering structures are an important part of our transport infrastructure. Their failure is associated with high safety risks and economic damage. Ensuring the availability of these constructions and guaranteeing their operational safety are thus important tasks. Currently, maintenance of engineering structures is a reactive process and therefore not yet a predictive process. Every 3 to 6 years, the structures are visually inspected, all damages are documented and a condition grade is assigned to the structure based on the detected damages. Continuous data-providing methods such as monitoring are used only very occasionally. With the help of monitoring, condition data about the structures are continuously collected, which can be used for a better assessment of the structures. On the one hand, this would increase safety of engineering structures, and on the other hand, it makes the shift towards predictive maintenance management based on real-time data and predictions, where the onset of damage is detected before it occurs, possible in the first place. Monitoring plays therefore an important role in the management of the infrastructure. It is a crucial a step towards the digitalisation of our infrastructure and existing processes. Although there are many use cases for monitoring that have already been successfully implemented, monitoring is not yet widely used by German road authorities due to several challenges that were also identified within the scope of the project. Therefore, a guide has been developed in which the current obstacles related to monitoring are identified and possibilities for integrating monitoring into existing processes are offered. To ensure optimal alignment with the needs of road authorities, both an online survey and a workshop have been conducted. The results are summarised in a brochure that is made available to authorities to improve the use of monitoring in Germany. This paper presents the guideline and the brochure. T2 - 10th European Workshop on Structural Health Monitoring (EWSHM 2024) CY - Potsdam, Germany DA - 10.06.2024 KW - Verkehrsinfrastrukturen KW - Engineering Structures KW - Bridges KW - Structural Health Monitoring KW - Guideline PY - 2024 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-612821 UR - https://www.ndt.net/search/docs.php3?id=29582 DO - https://doi.org/10.58286/29582 SN - 1435-4934 VL - 29 IS - 7 SP - 1 EP - 8 PB - NDT.net GmbH & Co. KG CY - Mayen AN - OPUS4-61282 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Herrmann, Ralf A1 - Hille, Falk A1 - Pitters, S. A1 - Ramasetti, Eshwar Kumar A1 - Schneider, Ronald A1 - Wedel, F. A1 - Hindersmann, I. ED - Rogge, Andreas ED - Meng, Birgit T1 - Föderiertes Datenmanagement von Monitoringdaten aus Structural Health Monitoring Anwendungen und daraus gewonnenen Trainingsdaten bei Spannbetonbrücken N2 - Beim Structural Health Monitoring entstehen eine Vielzahl von Daten, Metadaten und Modellen mit hohem Wert für die Beurteilung des Bauwerkszustands und der Prognose von Veränderungen. Kontinuierlich anwachsende Datenbestände müssen nachhaltig geteilt, genutzt und über die Bauwerkslebensdauer archiviert werden. Dabei stellen die Vielfalt der Messaufgaben, die Heterogenität der Daten, die dezentrale Erfassung und z. T. der Umfang eine Herausforderung für die beteiligten Akteure dar. Für den Datentransfer der Monitoringdaten zwischen der Straßenbauverwaltung und den Monitoringausführenden wird ein flexibles Abstimmungsverfahren vorgeschlagen und ein Lösungskonzept für ein föderiertes Datenmanagement skizziert. Eine weitere Herausforderung stellt die bauwerksübergreifende Zusammenstellung von Trainingsdaten für konkrete KI-Anwendungen dar. T2 - 11. Jahrestagung des DAfStb mit 63. Forschungskolloquium der BAM Green Intelligent Building CY - Berlin, Germany DA - 16.10.2024 KW - Structural Health Monitoring PY - 2024 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-612902 SN - 978-3-9818564-7-7 SP - 178 EP - 185 PB - Bundesanstalt für Materialforschung und -prüfung (BAM) CY - Berlin AN - OPUS4-61290 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Hille, Falk A1 - Herrmann, Ralf A1 - Pitters, S. A1 - Hindersmann, I. A1 - Schneider, Ronald A1 - Wedel, F. ED - Rogge, Andreas ED - Meng, Birgit T1 - Leitfaden für den strategischen Einsatz von Monitoring an Straßenbrücken N2 - Für die Anwendung von Structural Health Monitoring (SHM) im Rahmen des Managements von Straßenbrü-cken wurde zur Unterstützung von Straßenbauverwaltungen, Ingenieurbüros, Bauunternehmen und weiteren Akteuren die Erstellung eines Leitfadens initiiert. Dieser Leitfaden stellt typische Anwendungsfälle für Monito-ring vor und schlägt für diese bewährte Herangehensweisen vor. Darüber hinaus bietet der Leitfaden Empfeh-lungen für Ausschreibung und Vergabe von Monitoringleistungen, eine Anleitung zur Bewertung des wirt-schaftlichen Nutzens von SHM, Hinweise zur optimal einsetzbaren Messtechnik sowie einen Ansatz für das Datenmanagement zur Integration der Monitoringdaten in das Brückenmanagement. T2 - 11. Jahrestagung des DAfStb mit 63. Forschungskolloquium der BAM Green Intelligent Building CY - Berlin, Germany DA - 16.10.2024 KW - Leitfaden KW - Monitoring KW - Straßenbrücke PY - 2024 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-612931 SN - 978-3-9818564-7-7 SP - 186 EP - 191 PB - Bundesanstalt für Materialforschung und -prüfung (BAM) CY - Berlin AN - OPUS4-61293 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Ramos, Inês I. A1 - Carl, Peter A1 - Schneider, Rudolf A1 - Segundo, Marcela A. T1 - Development of automated immunosensing methods for clinical and environmental Analysis using lab-on-valve platforms N2 - The lab-on-valve (LOV) is a mesofluidic platform that has been recently exploited for the automation and miniaturization of bioanalytical assays, resorting namely to molecular recognition schemes based on immunosensing. Due to its high versatility for reagent accommodation, it is possible to establish immunoassays under several formats (eg. direct competitive ELISA, sandwich ELISA or even label-free immunoaffinity chromatography). For instance, the LOV has been used as a manifold for UV-vis micro-Bead Injection Spectroscopy (μ-BIS), a technique that involves the quantification of the target analyte by direct measurement on the surface of a solid phase capable of retaining the target analyte by molecular recognition. The μ-BIS-LOV strategy affords several analytical advantages, namely short time-toresult intervals (3 to 15 min), low sample volume (1-20 μL), automated solution handling and washing steps, downscaling of reagents’ consumption, low-cost analysis and little generation of waste. Additionally, the solid support is renewed before each determination, minimizing surface fouling, cross-contamination issues and functional group deactivation. No sample clean-up steps are required because interferences are separated from the target analyte upon quantification mediated by a molecular recognition element attached to the micro-bead column. The portability of the LOV device makes it compatible with point-of-care testing. To our knowledge, this technique has been mainly employed for the evaluation and optimization of bioaffinity processes, but its potential for clinical and environmental analysis remains underexploited. Hence, in this communication, different immunosensing strategies using the LOV platform will be addressed, namely the determination of autoimmune IgG in human serum, and the assessment of drug (carbamazepine) levels in wastewater samples. T2 - EBS 2017 CY - Potsdam, Germany DA - 20.03.2017 KW - Lab-on-valve KW - Automation KW - Immunoassay PY - 2017 AN - OPUS4-39521 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Almeida, Ângela A1 - Calisto, Vânia A1 - Domingues, M. Rosário M. A1 - Esteves, Valdemar I. A1 - Schneider, Rudolf A1 - Soares, Amadeu M.V.M. A1 - Figueira, Etelvina A1 - Freitas, Rosa T1 - Comparison of the toxicological impacts of carbamazepine and a mixture of its photodegradation products in Scrobicularia plana N2 - In the aquatic environment, pharmaceutical drugs are submitted to degradation processes, where pho-todegradation is one of the most important mechanisms affecting the fate, persistence and toxicity of thecompounds. Carbamazepine, a widely used antiepileptic, is known to suffer photodegradation in waterbodies and generate photoproducts, some of them with higher potential toxicity than the parent com-pound. Therefore, to evaluate the toxic effects of CBZ when combined with its photoproducts, an acuteexposure (96 h) with the edible clam Scrobicularia plana was performed using environmental concentra-tions of CBZ (0.00–9.00 µg/L) irradiated (and non-irradiated) with simulated solar radiation. The analysisof the irradiated CBZ solutions by mass spectrometry revealed the formation of 5 photoproducts, includ-ing acridine (a compound known to be carcinogenic). Oxidative stress results showed that the exposureto CBZ photoproducts did not increase the toxicity to clams, by comparison with the parent compound. KW - Pharmaceutical drugs KW - Photodegradation KW - Biomarkers KW - Oxidative stress KW - Bivalves PY - 2017 DO - https://doi.org/10.1016/j.jhazmat.2016.05.009 VL - 323 SP - 220 EP - 232 PB - Elsevier B.V. AN - OPUS4-39151 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Santos, S. A1 - Costa, C. A. E. A1 - Duarte, A. C. A1 - Scherer, H. W. A1 - Schneider, Rudolf A1 - Esteves, V. I. A1 - Santos, E. B. H. T1 - Influence of different organic amendments on the potential availability of metals from soil: A study on metal fractionation and extraction kinetics by EDTA N2 - The effects of long-term application of different organic amendments, as compared to mineral fertilizer, on Zn, Cu and Pb content and leachability in a luvisol derived from loess were assessed. The organic fertilizers, applied since 1962, were compost (COM) – from green organic household waste, sewage sludge (SLU) – from municipal water treatment facilities, farmyard manure (FYM) and the doses applied since 1997 were 90 t ha-1, 10 t ha-1 and 9 t ha-1, once in 3 years, respectively. The kinetics of metals extraction with 0.05 mol dm-3 EDTA at pH 6.0 has been studied. The two first-order reactions model was fitted to the kinetic data and allowed to distinguish two pools for each metal: a 'labile' fraction (Q1), quickly extracted with a rate constant k1, and a 'moderately labile' fraction (Q2), more slowly extracted, with a rate constant k2. Simultaneously, the pseudo-total metal contents in the soil samples were determined after digestion with aqua regia (3:1 HCl + HNO3). The obtained parameters Q1, k1, Q2, k2, for the kinetics of extraction of each metal in the three replicates of each fertilization mode, as well as the pseudo-total metal contents, were statistically analysed. COM and SLU application resulted in an increase of the total contents of Pb, Zn and Cu in soil. Further, the percentage of labile Zn and Pb also increased in consequence of the application of those amendments, particularly COM. The increase was more noticeable for Zn. FYM, despite not increasing the total content of Pb, Zn or Cu, did also have an effect on the leachability of Zn and Pb, increasing their labile fraction in soil. These results point to a potential risk of increasing metals mobility in soil, mainly Zn, associated to the use of organic amendments, particularly COM or SLU. KW - Compost KW - Sewage sludge KW - Soils KW - Metal mobility KW - EDTA KW - Kinetics PY - 2010 DO - https://doi.org/10.1016/j.chemosphere.2009.11.008 SN - 0045-6535 SN - 0366-7111 VL - 78 IS - 4 SP - 389 EP - 396 PB - Elsevier Science CY - Kidlington, Oxford AN - OPUS4-22187 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Anker, Andy S. A1 - Aspuru-Guzik, Alán A1 - Ben Mahmoud, Chiheb A1 - Bennett, Sophie A1 - Briling, Ksenia R. A1 - Changiarath, Arya A1 - Chong, Sanggyu A1 - Collins, Christopher M. A1 - Cooper, Andrew I. A1 - Crusius, Daniel A1 - Darmawan, Kevion K. A1 - Das, Basita A1 - David, Nicholas A1 - Day, Graeme M. A1 - Deringer, Volker L. A1 - Duarte, Fernanda A1 - Eardley-Brunt, Annabel A1 - Evans, Matthew L. A1 - Evans, Rob A1 - Fairlamb, Ian A1 - Franklin, Barnabas A. A1 - Frey, Jeremy A1 - Ganose, Alex M. A1 - Goulding, Mark A1 - Hafizi, Roohollah A1 - Hakkennes, Matthijs A1 - Hickey, Niamh A1 - James, Gillian A1 - Jelfs, Kim E. A1 - Kalikadien, Adarsh V. A1 - Kapil, Venkat A1 - Koczor-Benda, Zsuzsanna A1 - Krammer, Ferdinand A1 - Kulik, Heather J. A1 - Kumar, Vishank A1 - Kuttner, Christian A1 - Lam, Erwin A1 - Lou, Yuchen A1 - Mante, Eltjo A1 - Martin, Jennie A1 - Mroz, Austin M. A1 - Nematiaram, Tahereh A1 - Pare, Charles W. P. A1 - Patra, Sarbani A1 - Proudfoot, James A1 - Ruscic, Branko A1 - Ryder, Matthew R. A1 - Sakaushi, Ken A1 - Saßmannshausen, Jörg A1 - Savoie, Brett M. A1 - Schneider, Nadine A1 - Schwaller, Philippe A1 - Skjelstad, Bastian Bjerkem A1 - Sun, Wenhao A1 - Szczypiński, Filip T. A1 - Torrisi, Steven A1 - Ueltzen, Katharina A1 - Vishnoi, Shubham A1 - Walsh, Aron A1 - Wang, Xinwei A1 - Wilson, Chloe A1 - Wu, Ruiqi A1 - Zeitler, Jakob T1 - Discovering structure–property correlations: General discussion N2 - This article is a discussion of the paper "Web-BO: Towards increased accessibility of Bayesian optimisation (BO) for chemistry" by Austin M. Mroz, Piotr N. Toka, Ehecatl Antonio del Río Chanona and Kim E. Jelfs (Faraday discussions, 2025, 256, 221-234). KW - Materials design KW - Machine learning KW - Automation KW - Materials discovery PY - 2025 DO - https://doi.org/10.1039/d4fd90062f SN - 1359-6640 SN - 1364-5498 VL - 256 IS - Themed collection: Data-driven discovery in the chemical sciences SP - 373 EP - 412 PB - Royal Society of Chemistry (RSC) CY - Cambridge AN - OPUS4-62208 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Schneider, Thomas A1 - Vierneusel, B. A1 - Gradt, Thomas A1 - Tremmel, S. A1 - Wartzack, S. A1 - Szücs, Z. A1 - Arendt, I. T1 - Optimierte MoS2-PVD-Schichten für wechselnde Umgebungsbedingungen N2 - Der Festschmierstoff Molybdändisulfid ist insbesondere für Extremanwendungen, bei denen konventionelle Öl- oder Fettschmierung nicht in Frage kommen (Vakuum, hohe Pressungen) ein gerne eingesetzter Werkstoff. Problematisch ist jedoch der negative Einfluss von Feuchtigkeit, wodurch die Einsetzbarkeit von M0S2 unter Normalbedingungen leidet. Bei mittels PVD-Verfahren abgeschiedenen MoSa-Schichten ergibt sich jedoch die Möglichkeit, durch Anpassung der Beschichtungsparameter vorwiegend basal ausgerichtete Schichten herzustellen, die auch an normal feuchter Luft ein verbessertes tribologisches Verhalten zeigen. MoSa-Schichten sind darüber hinaus auch für Anwendungen bei extrem tiefen Temperaturen interessant, da hier kein Schmierstoff zur Verfügung steht, der ähnlich günstige Reibeigenschaften aufweist. Für bewegliche Stützelemente zwischen supraleitenden Magnetspulen des Kernfusions-Experiments Wendelstein 7-X waren bis zu 7 pm dicke Schichten entwickelt worden, die jedoch durch das notwendige langsame Aufwachsen für andere Anwendungen nicht wirtschaftlich herzustellen waren. Hier sollen neue, im Rahmen eines Kooperationsprojekts entstandene MoS2-PVD-Schichten vorgestellt werden, die bei wechselnden Umgebungsbedingungen noch gute tribologische Eigenschaften liefern, jedoch durch ihre Dicke von 1-2 pm und hoher Aufwachsrate kostengünstig sind. N2 - The solid lubricant molybdenum disulfide is a well known material for extreme conditions where conventlonal oll or grease lubrication is not feasible (vacuum, high pressures). Problems arise due to a negative effect of humidity which is a drawback for the suitability of M0S2 under normal conditions. However, by using a PVD process, Deposition parameters can be optimized to gain coatings with a more textured structure orienting the basal planes parallel to the Substrate surface. Therefore, an improved tribological behavior even under moist conditions can be achieved. MoS2-coatings additionally are interesting candidates for being applied under cryogenic temperatures, since no lubricant is available having similarly favorable frictional properties. Up to 7 pm thick coatings have been developed especially for sliding support elements between superconducting magnets of the fusion-experiment Wendelstein 7-X, however, the extremely slow deposition rate precluded its utilization on more common tribo-systems due to cost considerations. Here, new MoS2-coatings are presented which were developed in a cooperational project, giving good tribological results under variing environments but are more cost effective being only 1-2 pm in thickness and faster in film growth.. T2 - 53. Tribologie-Fachtagung - Reibung, Schmierung und Verschleiß CY - Göttingen, Germany DA - 24.09.2012 PY - 2012 SN - 978-3-00-039201-6 SP - 46/1 EP - 46/12 CY - Aachen AN - OPUS4-26724 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Hickel, Tilmann A1 - Divinski, S. A1 - Starikov, S. A1 - Soisson, F. A1 - Mény, C. A1 - Hegde, O. A1 - Gerlitz, M. A1 - Magnifouet, G. A1 - Schneider, A. A1 - Barreteau, C. A1 - Mirebeau, I. A1 - Tran, V.T. A1 - Förster, G. A1 - Front, A. A1 - Egorov, A. A1 - Wilde, G. A1 - Amara, H. A1 - Hammerschmidt, T. A1 - Mrovec, M. A1 - Pierron-Bohnes, V. A1 - Drautz, R. A1 - Fu, C. T1 - Magnetism in iron alloys: methodological advances for thermodynamics, defects, and kinetics N2 - Steels are among the technologically and economically most relevant materials. Key innovations in important sectors of human society such as mobility, energy and safety, are currently based on alloying of Fe with other transition-metal elements such as Mn, Cr, or Co. Due to strong impacts and conceptual challenges related to magnetism, however, the fundamental understanding and the ability to computationally design these steels in high-throughput approaches lags behind other classes of alloys. In this article, we will provide a substantial review of the role of magnetism, magnetic excitations and transformations for alloy thermodynamics, point defects, interfaces and kinetics. This will be achieved by combining insights from different methods: Ab initio simulations have the advantage that the magnetic ground state is intrinsic part of the electronic minimization. Due to the coarsening of the many-electron structures and therewith magnetic interactions, tight-binding methods can handle larger system sizes. Effective interaction models provide the freedom to exploit more sophisticated magnetic interactions. The performance of these methods in terms of magnetic properties of Fe alloys will be evaluated by providing state-of-the-art results for their sensitivity to magnetism. Furthermore, dedicated experiments will be discussed to complete the understanding of magnetic effects in Fe alloys and to validate the modeling strategy. KW - Magnetic excitations KW - Defects KW - Diffusion KW - Density functional theory KW - Tight-binding KW - Effective interaction models PY - 2025 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b43-634530 DO - https://doi.org/10.1515/ijmr-2023-0225 SN - 1862-5282 VL - 60 IS - 99 SP - 1 EP - 14761 PB - Walter de Gruyter GmbH AN - OPUS4-63453 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - JOUR A1 - Schneider, I. A1 - Kebelmann, Katharina A1 - Risse, S. A1 - Dieguez-Alonso, A. A1 - Schartel, Bernhard A1 - Strecker, C. A1 - Behrendt, F. T1 - Hydroliquefaction of Two Kraft Lignins in a Semibatch Setup under Process Conditions Applicable for Large-Scale Biofuel Production N2 - Hydroliquefaction is a possible pathway to produce liquid transportation fuels from solid feedstocks like coal or biomass. Though much effort has been put into the investigation of maximizing the oil yield using expensive catalysts and pasting oils in batch setups, little is known about how to commercialize the process. This work aims at the demonstration of lignin hydroliquefaction under conditions interesting for commercial operation. The results from hydroliquefaction experiments of two different lignin types using a cheap iron-based catalyst and anthracene oil as the pasting oil in a semibatch system are presented here. Oil yields of above 50% are reached without observing coke formation. Extensive analyses of the feedstocks and product oils were performed. The process supplies high-quality oil, while differences in the decomposition path of both lignin types are observed. An high heating value of 39 400 J/g and H/C and O/C ratios of up to 1.6 and 0.1, respectively, are detected for the produced bio-oils. KW - Lignin KW - Hydroliquefaction KW - Biofuel PY - 2019 DO - https://doi.org/10.1021/acs.energyfuels.9b02572 SN - 0887-0624 SN - 1520-5029 VL - 33 IS - 11 SP - 11057 EP - 11066 PB - ACS AN - OPUS4-50102 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -