TY - JOUR A1 - Bhatia, S. A1 - Donskyi, Ievgen A1 - Block, S. A1 - Nie, C. A1 - Burdinski, A. A1 - Lauster, D. A1 - Radnik, Jörg A1 - Herrmann, A. A1 - Haag, R. A1 - Ludwig, K. A1 - Adeli, M. T1 - Wrapping and Blocking of Influenza A Viruses by Sialylated 2D Nanoplatforms N2 - Inhibition of respiratory viruses is one of the most urgent topics as underlined by different pandemics in the last two decades. This impels the development of new materials for binding and incapacitation of the viruses. In this work, we have demonstrated that an optimal deployment of influenza A virus (IAV) targeting ligand sialic acid (SA) on a flexible 2D platform enables its binding and wrapping around IAV particles. A series of 2D sialylated platforms consisting graphene and polyglycerol are prepared with different degrees of SA functionalization around 10%, 30%, and 90% named as G-PG-SAL, G-PG-SAM, and G-PG-SAH, respectively. The cryo-electron tomography (Cryo-ET) analysis has proved wrapping of IAV particles by G-PG-SAM. A confocal-based colocalization assay established for these materials has offered the comparison of binding potential of sialylated and non-sialylated nanoplatforms for IAV. With this method, we have estimated the binding potential of the G-PG-SAM and G-PG-SAH sheets for IAV particles around 50 and 20 times higher than the control sheets, respectively, whereas the low functionalized G-PG-SAL have not shown any significant colocalization value. Moreover, optimized G-PG-SAM exhibits high potency to block IAV from binding with the MDCK cells. KW - 2D Materials KW - Graphhene KW - Influenza A virus KW - Sialic acid KW - wrapping PY - 2021 DO - https://doi.org/10.1002/admi.202100285 VL - 8 IS - 12 SP - 285 PB - Wiley VCH AN - OPUS4-52715 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - RPRT A1 - Block, S. A1 - Boß, K.-H. A1 - Frobese, D.-H. A1 - Pape, H. A1 - Gösslinghoff, L. A1 - Grossepieper, T. A1 - Kasper, R. A1 - Kirchner, W. A1 - Kollmann, P. A1 - Kröger, P. A1 - Ringlstetter, P. A1 - Kuska, T. A1 - Mattejat, K. A1 - Niehüser, H. A1 - Pfeiffer, F. A1 - Pötzsch, Klaus-Michael A1 - Jochems, Frank A1 - Schäfer, H. A1 - Vogt, W. A1 - Zankl, C. A1 - Ludzay, J. T1 - Empfehlungen zur Vermeidung von Überdrücken an Tankfahrzeugen bei Untenbefüllung KW - Untenbefüllung KW - Tankfahrzeuge KW - Überdruck KW - Mineralöl KW - Sicherheitsventile PY - 2012 VL - 727 IS - 3 SP - 1-4, Anl. 1-3 AN - OPUS4-27921 LA - deu AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER - TY - CONF A1 - Georg, Paul A1 - Block, R. A1 - Heister, W. A1 - Holl, S. A1 - Pulm, A. A1 - Hofmann-Böllinghaus, Anja T1 - A score regarding the need for assistance - considering pedestrians with impairments in evacuation planning N2 - The capabilities of pedestrians for evacuation have a significant impact on the time required to reach a safe place. Usually, the evacuation is split into two main stages: pre-movement-phase and movement-phase. For both a large number of studies investigate different representations of behaviour and impacts. But the influence of impairments is usually not taken into account. In addition, most of the scientific researches focus the investigation of the movement phase. This publication presents a novel approach to score the need for assistance and to estimate the effect on evacuation performance. The proposed score considers characteristic impairments in three dimensions of behaviour: reception, perception and realisation. In an unannounced evacuation training in a sheltered workshop, the evacuation behaviour and pre-movement phase were analysed. The analysis indicates that the pre-movement time depends on the kind of impairment as well as on organisational boundaries. Despite the special needs for assistance, the evacuation process in a sheltered workshop is quite similar to other sub-populations. T2 - 5. Magdeburger Brand- und Explosionsschutztage 2017 CY - Magdeburg, Germany DA - 23.03.2017 KW - Human behaviour KW - Human factors KW - Egress KW - Evacuation KW - Persons with impairments PY - 2017 SN - 978-3-00-056201-3 DO - https://doi.org/10.978.300/0562013 SP - 1 EP - 13 CY - Magdeburg AN - OPUS4-40051 LA - eng AD - Bundesanstalt fuer Materialforschung und -pruefung (BAM), Berlin, Germany ER -